Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The role of protein kinase C (PKC) on muscarinic regulation of serotonin release in the pineal gland was investigated by measuring the pineal-PKC activity and serotonin secretion in response to muscarinic agents. Pineal slices, short-term incubated (0-15 min) without additions produced a low serotonin release and 20 to 24 percent PKC activity was found associated with membrane fractions. Prolonged exposure of pineal slices (30-180 min) produced further translocation of PKC activity to the membranes and a significant increase of serotonin release. Short-term treatment with pilocarpine and carbachol, stimulated PKC activity of both cytosolic and particulate fractions and the release of pineal serotonin. The pilocarpine effect was blocked by atropine indicating that it was mediated by muscarinic receptors. The present data support that PKC activation correlates with the increase of serotonin release by muscarinic agonist in pineal gland. © 1991.

Registro:

Documento: Artículo
Título:Effects of cholinergic muscarinic agents on protein kinase C activity in rat pineal gland
Autor:Finocchiaro, L.M.E.; Téllez-Iñón, M.T.
Filiación:Laboratorio de Sustancias Vasoactivas, Institute de Investigaciones Médicas, Universidad de Buenos Aires, Donate Alvarez 3150, 1427 Buenos Aires, Argentina
Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI-CONICET), Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:muscarinic activation; pineal gland; protein kinase C; serotonin; angiotensin; atropine; carbachol; isoprenaline; muscarinic agent; muscarinic receptor; pilocarpine; protein kinase c; serotonin; staurosporine; animal experiment; animal tissue; article; cholinergic activity; controlled study; enzyme activity; long term exposure; male; metabolic regulation; nonhuman; pineal body; priority journal; rat; serotonin release; Angiotensin II; Animal; Atropine; Carbachol; Cell Membrane; Cytoplasm; Isoproterenol; Male; Parasympathomimetics; Pilocarpine; Pineal Gland; Protein Kinase C; Rats; Rats, Inbred Strains; Serotonin; Support, Non-U.S. Gov't
Año:1991
Volumen:15
Número:10
Página de inicio:943
Página de fin:954
DOI: http://dx.doi.org/10.1016/0309-1651(91)90144-8
Título revista:Cell Biology International Reports
Título revista abreviado:Cell Biol. Int. Rep.
ISSN:03091651
CODEN:CBRPD
CAS:Angiotensin II, 11128-99-7; Atropine, 51-55-8; Carbachol, 51-83-2; Isoproterenol, 7683-59-2; Parasympathomimetics; Pilocarpine, 92-13-7; Protein Kinase C, EC 2.7.1.37; Serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03091651_v15_n10_p943_Finocchiaro

Referencias:

  • Abdel-Latif, Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers (1986) Pharmacol. Rev, 38, pp. 227-272
  • Ananth, Leli, Hauser, Stimulation of phosphoinositide hydrolisis by serotonin in C6 Glioma cells (1987) J. Neurochem, 48, pp. 253-261
  • Berridge, Irvine, Inositoltriphosphate, a novel second messenger in cellular signal transduction (1984) Nature, 312, pp. 315-321
  • Bocckino, Blackmore, Exton, Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine and angiotensin II (1985) J. Biol. Chem, 260, pp. 14201-14207
  • Finocchiaro, Goldstein, Finkielman, Nahmod, Interaction of Angiotensin II with the Cholinergic and Noradrenergic Systems in the Rat Pineal Gland: Regulation of Indole Metabolism (1990) J. Endocrinol, 126, pp. 59-66
  • Finocchiaro, Scheucher, Finkielnan, Nahmod, Pirola, Muscarinic effects on the hydroxy and methoxyindole pathway in the rat pineal gland (1989) J. Endocrinol, 123, pp. 205-211
  • Gómez, Medrano, Cafferatta, Téllez-Iñón, Protein kinase C is differentially regulated by trombin insulin and epidermal growth factor in human mammary tumor cells (1988) Experimental Cell Research, 175, pp. 74-80
  • Hirota, Hirota, Aguilera, Catt, Hormone-induced redistribution of calcium-activated phospholipid dependent protein kinase in pituitary gonatrophs (1985) J. Biol. Chem, 260, pp. 3243-3246
  • Ho, Chik, Klein, Protein kinase C is involved in adrenergic stimulation of pineal cGMP accumulation (1987) J. Biol. Chem, 262, pp. 10050-10064
  • Ho, Thomas, Chik, Anderson, Klein, Protein kinase C: Subcellular redistribution by increased Ca2+ influx (1988) J. Biol. Chem, 263, pp. 9292-9297
  • Ishizuka, Cooper, Farese, Insulin stimulates the translocation of protein kinase C in rat adipocytes (1989) FEBS Letters, 257, pp. 337-340
  • Kikkawa, Ogita, Shearman, Ase, Sekiguchi, Naor, Ido, Igarashi, The heterogeneity and differential expression of protein kinase C in nervous tissues (1988) Phil. Trans. Roy. Soc. London, 320 B, pp. 313-324
  • Kraft, Anderson, Characterization of cytosolic calcium-activated phospholipid-dependent protein kinase activity in embryonal carcinoma cells (1983) J. Biol. Chem, 258, pp. 9178-9183
  • Laitinen, Torda, Saavedra, Cholinergic stimulation of phosphoinositide hydrolysis in the rat pineal gland (1989) European J. Pharmacol, 161, pp. 237-240
  • Lowry, Resebrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem, 193, pp. 265-275
  • Nishizuka, The role of protein kinase C in cell surface signal transduction and tumor promotion (1984) Nature, 308, pp. 693-698
  • Persaud, Jones, Sudgen, Howell, The role of protein kinase C in cholinergic stimulation of insulin secretion from rat islets of Langerhans (1989) Biochem. J, 264, pp. 753-758
  • Rasmussen, Barret, Mechanism of action of Ca2+-dependent hormones (1988) Hormones and their Actions, pp. 93-111. , BA Cooke, RJB King, van der Molen, Elsevier Science Publishers BV, Part II
  • Sugden, Vanecek, Klein, Thomas, Anderson, Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes (1985) Nature, 314, pp. 359-361
  • Tamaoki, Nomoto, Takahashi, Kato, Morimoto, Tomita, Staurosporine: a potent inhibitor of phospholipid/Ca2+ -dependent protein kinase (1986) Biochem. Biophys. Res. Commun, 135, pp. 397-402
  • Wang, Friedman, Protein kinase C regulation of serotonin release from rat brain cortical slices (1987) European Journal of Pharmacology, 141, pp. 15-21
  • White, Pluznik, Ishizaka, Ishizaka, Antigen-induced increase in protein kinase C activity in plasma membrane of mast cells (1985) Proc. Nat. Acad. Sci. USA, 82, pp. 8193-8197

Citas:

---------- APA ----------
Finocchiaro, L.M.E. & Téllez-Iñón, M.T. (1991) . Effects of cholinergic muscarinic agents on protein kinase C activity in rat pineal gland. Cell Biology International Reports, 15(10), 943-954.
http://dx.doi.org/10.1016/0309-1651(91)90144-8
---------- CHICAGO ----------
Finocchiaro, L.M.E., Téllez-Iñón, M.T. "Effects of cholinergic muscarinic agents on protein kinase C activity in rat pineal gland" . Cell Biology International Reports 15, no. 10 (1991) : 943-954.
http://dx.doi.org/10.1016/0309-1651(91)90144-8
---------- MLA ----------
Finocchiaro, L.M.E., Téllez-Iñón, M.T. "Effects of cholinergic muscarinic agents on protein kinase C activity in rat pineal gland" . Cell Biology International Reports, vol. 15, no. 10, 1991, pp. 943-954.
http://dx.doi.org/10.1016/0309-1651(91)90144-8
---------- VANCOUVER ----------
Finocchiaro, L.M.E., Téllez-Iñón, M.T. Effects of cholinergic muscarinic agents on protein kinase C activity in rat pineal gland. Cell Biol. Int. Rep. 1991;15(10):943-954.
http://dx.doi.org/10.1016/0309-1651(91)90144-8