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Abstract:

In the brain specialized cells known as 'neuroendocrine transducers' translate an input of neural activity into a hormonal output, e.g. oxytocin released into the blood stream. Other, more typical neurons make the reverse conversion constituting chemoreceptors which transform the hormonal 'language' into changes in their firing rate ('endocrine - neural' transduction). 'Endocrine-endocrine' transducing events occur at the level of the neurosecrotary cells that translate a hormonal signal into another, different, hormone output. This article reviews the molecular aspects of several neuroendocrine integrative processes in the hypothalamus, the pineal gland and the cervical sympathetic pathway. The discussed results indicate that the pineal gland and its innervating sympathetic neurons located in the superior cervical ganglia constitute an easy-to-manipulate model system for the study of basic neuroendocrine mechanisms because: (i) receptors for various hormones exist in the mammalian pineal and sympathetic ganglia; (ii) the pattern of pineal steroid metabolism resembles that of the neuroendocrine hypothalamus; (iii) pineal estrophilic and androphilic receptors as well as the pattern of steroid metabolism are modulated by the sympathetic nerves; (iv) neuronal activity in the cervical sympathetic pathway is modified by hormone treatment at preganglionic, ganglionic and postganglionic sites. © 1983.

Registro:

Documento: Artículo
Título:Molecular mechanisms of neuroendocrine integration in the central nervous system: An approach through the study of the pineal gland and its innervating sympathetic pathway
Autor:Cardinali, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Buenos Aires, Argentina
Palabras clave:adrenergic receptors; hormone receptors; neuroendocrine mechanisms; neurotransmitters; Pineal gland; prostaglandins; superior cervical ganglion; testosterone; acetylsalicylic acid; adrenergic receptor; androgen; estrogen; hormone receptor; indometacin; mefenamic acid; neurotransmitter; noradrenalin; phentolamine; prolactin i 125; propranolol; prostaglandin; prostaglandin e1; prostaglandin e2; prostaglandin f2 alpha; radioisotope; steroid; testosterone; adrenergic system; animal; autonomic nervous system; central nervous system; dihydroalprenolol h 3; drug efficacy; endocrine system; hypothalamus; nonhuman; pineal body; postganglionic nerve cell; preganglionic nerve cell; review; superior cervical ganglion; testosterone c 14; Animal; Cyclic AMP; Dinoprost; Dinoprostone; Ganglia, Sympathetic; Gonadotropins, Pituitary; Hypothalamus; Models, Neurological; Neurons; Neurosecretion; Neurotransmitters; Norepinephrine; Pineal Gland; Prostaglandins E; Prostaglandins F; Rats; Receptors, Adrenergic, beta; Receptors, Cholinergic; Support, Non-U.S. Gov't; Testosterone
Año:1983
Volumen:8
Número:1
Página de inicio:3
Página de fin:30
DOI: http://dx.doi.org/10.1016/0306-4530(83)90038-0
Título revista:Psychoneuroendocrinology
Título revista abreviado:Psychoneuroendocrinology
ISSN:03064530
CODEN:PSYCD
CAS:acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; indometacin, 53-86-1, 74252-25-8, 7681-54-1; mefenamic acid, 61-68-7; noradrenalin, 1407-84-7, 51-41-2; phentolamine, 50-60-2, 73-05-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; testosterone, 58-22-0; Cyclic AMP, 60-92-4; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Gonadotropins, Pituitary; Neurotransmitters; Norepinephrine, 51-41-2; Prostaglandins E; Prostaglandins F; Receptors, Adrenergic, beta; Receptors, Cholinergic; Testosterone, 57-85-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064530_v8_n1_p3_Cardinali

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Citas:

---------- APA ----------
(1983) . Molecular mechanisms of neuroendocrine integration in the central nervous system: An approach through the study of the pineal gland and its innervating sympathetic pathway. Psychoneuroendocrinology, 8(1), 3-30.
http://dx.doi.org/10.1016/0306-4530(83)90038-0
---------- CHICAGO ----------
Cardinali, D.P. "Molecular mechanisms of neuroendocrine integration in the central nervous system: An approach through the study of the pineal gland and its innervating sympathetic pathway" . Psychoneuroendocrinology 8, no. 1 (1983) : 3-30.
http://dx.doi.org/10.1016/0306-4530(83)90038-0
---------- MLA ----------
Cardinali, D.P. "Molecular mechanisms of neuroendocrine integration in the central nervous system: An approach through the study of the pineal gland and its innervating sympathetic pathway" . Psychoneuroendocrinology, vol. 8, no. 1, 1983, pp. 3-30.
http://dx.doi.org/10.1016/0306-4530(83)90038-0
---------- VANCOUVER ----------
Cardinali, D.P. Molecular mechanisms of neuroendocrine integration in the central nervous system: An approach through the study of the pineal gland and its innervating sympathetic pathway. Psychoneuroendocrinology. 1983;8(1):3-30.
http://dx.doi.org/10.1016/0306-4530(83)90038-0