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Vinuesa, A.; Pomilio, C.; Menafra, M.; Bonaventura, M.M.; Garay, L.; Mercogliano, M.F.; Schillaci, R.; Lux Lantos, V.; Brites, F.; Beauquis, J.; Saravia, F. "Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity" (2016) Psychoneuroendocrinology. 72:22-33
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Abstract:

The incidence of metabolic disorders including obesity, type 2 diabetes and metabolic syndrome have seriously increased in the last decades. These diseases – with growing impact in modern societies – constitute major risk factors for neurodegenerative disorders such as Alzheimer's disease (AD), sharing insulin resistance, inflammation and associated cognitive impairment. However, cerebral cellular and molecular pathways involved are not yet clearly understood. Thus, our aim was to study the impact of a non-severe high fat diet (HFD) that resembles western-like alimentary habits, particularly involving juvenile stages where the brain physiology and connectivity are in plain maturation. To this end, one-month-old C57BL/6J male mice were given either a control diet or HFD during 4 months. Exposure to HFD produced metabolic alterations along with changes in behavioral and central parameters, in the absence of obesity. Two-month-old HFD mice showed increased glycemia and plasmatic IL1β but these values normalized at the end of the HFD protocol at 5 months of age, probably representing an acute response that is compensated at later stages. After four months of HFD exposure, mice presented dyslipidemia, increased Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, hepatic insulin resistance and inflammation. Alterations in the behavioral profile of the HFD group were shown by the impediment in nest building behavior, deficiencies in short and mid-term spatial memories, anxious and depressive- like behavior. Regarding the latter disruptions in emotional processing, we found an increased neural activity in the amygdala, shown by a greater number of c-Fos+ nuclei. We found that hippocampal adult neurogenesis was decreased in HFD mice, showing diminished cell proliferation measured as Ki67+ cells and neuronal differentiation in SGZ by doublecortin labeling. These phenomena were accompanied by a neuroinflammatory and insulin-resistant state in the hippocampus, depicted by a reactive phenotype in Iba1+ microglia cells (increased in number and soma size) and an impaired response to insulin given by decreased phosphorylated Akt levels and increased levels of inhibitory phosphorylation of IRS1. Our data portray a set of alterations in behavioral and neural parameters as a consequence of an early-life exposure to a quite moderate high fat diet, many of which can resemble AD-related features. These results highly emphasize the need to study how metabolic and neurodegenerative disorders are interrelated in deep, thus allowing the finding of successful preventive and therapeutic approaches. © 2016 Elsevier Ltd

Registro:

Documento: Artículo
Título:Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity
Autor:Vinuesa, A.; Pomilio, C.; Menafra, M.; Bonaventura, M.M.; Garay, L.; Mercogliano, M.F.; Schillaci, R.; Lux Lantos, V.; Brites, F.; Beauquis, J.; Saravia, F.
Filiación:Neurobiology of Aging, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina
Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Cognitive performance; Emotionality; High fat diet; Hippocampal neuroinflammation; Neurogenesis; Periadolescence; insulin receptor substrate 1; insulin receptor substrate 2; interleukin 1beta; Ki 67 antigen; phospholipase A2; protein c fos; protein kinase B; tumor necrosis factor alpha; adult; amygdala; animal experiment; animal model; animal tissue; anxiety; Article; behavior change; cell proliferation; controlled study; dentate gyrus; depression; disease association; dyslipidemia; enzyme activity; enzyme phosphorylation; gene expression; insulin resistance; lipid composition; lipid diet; male; memory disorder; motivation; mouse; nervous system inflammation; nonhuman; obesity; population exposure; priority journal; protein blood level; protein expression; protein phosphorylation; short term memory; spatial memory; amygdala; animal; animal behavior; C57BL mouse; cognitive defect; dyslipidemia; hippocampus; hyperinsulinism; inflammation; lipid diet; metabolism; nervous system development; pathology; pathophysiology; physiology; Amygdala; Animals; Behavior, Animal; Cognitive Dysfunction; Diet, High-Fat; Dyslipidemias; Hippocampus; Hyperinsulinism; Inflammation; Male; Mice; Mice, Inbred C57BL; Neurogenesis
Año:2016
Volumen:72
Página de inicio:22
Página de fin:33
DOI: http://dx.doi.org/10.1016/j.psyneuen.2016.06.004
Título revista:Psychoneuroendocrinology
Título revista abreviado:Psychoneuroendocrinology
ISSN:03064530
CODEN:PSYCD
CAS:insulin receptor substrate 1, 175335-32-7; insulin receptor substrate 2, 223747-03-3; phospholipase A2, 9001-84-7; protein kinase B, 148640-14-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064530_v72_n_p22_Vinuesa

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Citas:

---------- APA ----------
Vinuesa, A., Pomilio, C., Menafra, M., Bonaventura, M.M., Garay, L., Mercogliano, M.F., Schillaci, R.,..., Saravia, F. (2016) . Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity. Psychoneuroendocrinology, 72, 22-33.
http://dx.doi.org/10.1016/j.psyneuen.2016.06.004
---------- CHICAGO ----------
Vinuesa, A., Pomilio, C., Menafra, M., Bonaventura, M.M., Garay, L., Mercogliano, M.F., et al. "Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity" . Psychoneuroendocrinology 72 (2016) : 22-33.
http://dx.doi.org/10.1016/j.psyneuen.2016.06.004
---------- MLA ----------
Vinuesa, A., Pomilio, C., Menafra, M., Bonaventura, M.M., Garay, L., Mercogliano, M.F., et al. "Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity" . Psychoneuroendocrinology, vol. 72, 2016, pp. 22-33.
http://dx.doi.org/10.1016/j.psyneuen.2016.06.004
---------- VANCOUVER ----------
Vinuesa, A., Pomilio, C., Menafra, M., Bonaventura, M.M., Garay, L., Mercogliano, M.F., et al. Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity. Psychoneuroendocrinology. 2016;72:22-33.
http://dx.doi.org/10.1016/j.psyneuen.2016.06.004