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Abstract:

In Autism Spectrum Disorders (ASD), a bias to a higher incidence in boys than in girls has been reported. With the aim to identify biological mechanisms acting in female animals that could underlie this bias, we used an extensively validated mouse model of ASD: the prenatal exposure to valproic acid (VPA). We found postnatal behavioral alterations in female VPA pups: a longer latency in righting reflex at postnatal day (P) 3, and a delay in the acquisition of the acoustic startle response. We also analyzed the density of glial cells in the prefrontal cortex, hippocampus and cerebellum, in VPA and control animals. Female VPA pups showed alterations in the density of astrocytes and microglial cells between P21 and P42, with specific dynamics in each brain region. We also found a decrease in histone 3 acetylation in the cerebellum of female VPA pups at P14, suggesting that the changes in glial cell density could be due to alterations in the epigenetic developmental program. Finally, no differences in maternal behavior were found. Our results show that female VPA pups exhibit behavioral and inflammatory alterations postnatally, although they have been reported to have normal levels of sociability in adulthood. With our work, we contribute to the understanding of biological mechanisms underlying different effects of VPA on male and female rodents, and we hope to help elucidate whether there are factors increasing susceptibility to ASD in boys and/or resilience in girls. © 2016 Elsevier Ltd

Registro:

Documento: Artículo
Título:Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid
Autor:Kazlauskas, N.; Campolongo, M.; Lucchina, L.; Zappala, C.; Depino, A.M.
Filiación:Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, Department of Physiology, Molecular and Cellular Biology, FCEyN, University of Buenos Aires, Buenos Aires, C1428EHA, Argentina
Palabras clave:Astrocyte; Autism spectrum disorder; HDAC; Hypothalamus-pituitary-adrenal response; Microglia; Purkinje cells; histone H3; valproic acid; GABAergic receptor affecting agent; valproic acid; acoustic reflex; adult; animal experiment; animal model; animal tissue; Article; astrocyte; auditory stimulation; body weight; cell density; controlled study; developmental stage; female; grip strength; histone acetylation; hypothalamus hypophysis adrenal system; male; microglia; mouse; nerve cell differentiation; nervous system inflammation; nonhuman; prenatal drug exposure; priority journal; Purkinje cell; sex difference; startle reflex; stereotypy; animal; animal behavior; brain; cell count; cytology; maternal behavior; metabolism; physiology; pregnancy; prenatal exposure; Animals; Astrocytes; Behavior, Animal; Brain; Cell Count; Female; GABA Agents; Maternal Behavior; Mice; Microglia; Pregnancy; Prenatal Exposure Delayed Effects; Reflex, Startle; Valproic Acid
Año:2016
Volumen:72
Página de inicio:11
Página de fin:21
DOI: http://dx.doi.org/10.1016/j.psyneuen.2016.06.001
Título revista:Psychoneuroendocrinology
Título revista abreviado:Psychoneuroendocrinology
ISSN:03064530
CODEN:PSYCD
CAS:valproic acid, 1069-66-5, 99-66-1; GABA Agents; Valproic Acid
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064530_v72_n_p11_Kazlauskas

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Citas:

---------- APA ----------
Kazlauskas, N., Campolongo, M., Lucchina, L., Zappala, C. & Depino, A.M. (2016) . Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid. Psychoneuroendocrinology, 72, 11-21.
http://dx.doi.org/10.1016/j.psyneuen.2016.06.001
---------- CHICAGO ----------
Kazlauskas, N., Campolongo, M., Lucchina, L., Zappala, C., Depino, A.M. "Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid" . Psychoneuroendocrinology 72 (2016) : 11-21.
http://dx.doi.org/10.1016/j.psyneuen.2016.06.001
---------- MLA ----------
Kazlauskas, N., Campolongo, M., Lucchina, L., Zappala, C., Depino, A.M. "Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid" . Psychoneuroendocrinology, vol. 72, 2016, pp. 11-21.
http://dx.doi.org/10.1016/j.psyneuen.2016.06.001
---------- VANCOUVER ----------
Kazlauskas, N., Campolongo, M., Lucchina, L., Zappala, C., Depino, A.M. Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid. Psychoneuroendocrinology. 2016;72:11-21.
http://dx.doi.org/10.1016/j.psyneuen.2016.06.001