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Abstract:

Maternal immune activation can result in different behavioral abnormalities and brain dysfunction, depending on the nature of the inflammogen and the timing of the challenge. Few studies report the possible link between prenatal exposure to inflammation and mood disorders. Here we aimed to evaluate the effects of a single low lipopolysaccharide (LPS) injection to the dam at gestational day 9 on the offspring behavior and hippocampal function. We found that mice exposed to LPS show anxiety- and depression-related behaviors. Specifically, we found that animals prenatally exposed to LPS avoided the open arms of an elevated plus maze, the center of an open field and the lit side of a light/dark box, and they spent more time immobile in both the forced swimming and tail suspension tests, when compared with offspring of saline-injected dams. In addition, LPS mice had reduced serotonin and noradrenaline levels in the hippocampus and diminished Reelin immunoreactivity in the dentate gyrus, while their adult hippocampal neurogenesis was not affected. Results presented here support specific long-term effects of the response to a bacterial immunogen early in pregnancy, as opposed to different effects previously reported of viral immunogens and/or responses in late pregnancy. Our work adds to recent reports and stresses the relevance of considering prenatal exposure to a maternal immune response as a risk factor for mood disorders. © 2015 IBRO.

Registro:

Documento: Artículo
Título:Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood
Autor:Depino, A.M.
Filiación:Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, and Department of Physiology, Molecular and Cellular Biology, FCEyN, University of Buenos Aires, Buenos Aires, C1428EHA, Argentina
Palabras clave:Maternal immune activation; Mood disorders; Neurogenesis; Reelin; Serotonin; lipopolysaccharide; noradrenalin; reelin; serotonin; sodium chloride; nerve cell adhesion molecule; nerve protein; noradrenalin; reelin protein; scleroprotein; serine proteinase; serotonin; adult; adulthood; animal cell; animal experiment; animal model; animal tissue; anxiety; Article; bacterial infection; behavior disorder; brain function; controlled study; dentate gyrus; depression; disease association; elevated plus maze test; female; forced swim test; gestation period; hippocampus; immunoreactivity; inflammation; male; maternal disease; molecular pathology; mouse; nervous system development; nonhuman; open field behavior; prenatal exposure; priority journal; progeny; tail suspension test; animal; anxiety; C57BL mouse; chemically induced; chemistry; complication; depression; drug effects; inflammation; metabolism; motor activity; pathophysiology; pregnancy; prenatal exposure; psychology; Animals; Anxiety; Cell Adhesion Molecules, Neuronal; Depression; Extracellular Matrix Proteins; Female; Hippocampus; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Pregnancy; Prenatal Exposure Delayed Effects; Serine Endopeptidases; Serotonin
Año:2015
Volumen:299
Página de inicio:56
Página de fin:65
DOI: http://dx.doi.org/10.1016/j.neuroscience.2015.04.065
Título revista:Neuroscience
Título revista abreviado:Neuroscience
ISSN:03064522
CODEN:NRSCD
CAS:noradrenalin, 1407-84-7, 51-41-2; serotonin, 50-67-9; sodium chloride, 7647-14-5; serine proteinase, 37259-58-8; Cell Adhesion Molecules, Neuronal; Extracellular Matrix Proteins; Lipopolysaccharides; Nerve Tissue Proteins; Norepinephrine; reelin protein; Serine Endopeptidases; Serotonin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v299_n_p56_Depino

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Citas:

---------- APA ----------
(2015) . Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood. Neuroscience, 299, 56-65.
http://dx.doi.org/10.1016/j.neuroscience.2015.04.065
---------- CHICAGO ----------
Depino, A.M. "Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood" . Neuroscience 299 (2015) : 56-65.
http://dx.doi.org/10.1016/j.neuroscience.2015.04.065
---------- MLA ----------
Depino, A.M. "Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood" . Neuroscience, vol. 299, 2015, pp. 56-65.
http://dx.doi.org/10.1016/j.neuroscience.2015.04.065
---------- VANCOUVER ----------
Depino, A.M. Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood. Neuroscience. 2015;299:56-65.
http://dx.doi.org/10.1016/j.neuroscience.2015.04.065