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Abstract:

Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory reconsolidation of an inhibitory avoidance task in CF-1 mice. We found a retrieval-induced cytosolic ERK2 activation in the hippocampus (HIP) 15. min after memory reactivation, and an inhibition at 45. min. PD098059, a MEK1/2 (MAPK/ERK kinase) inhibitor, administered in the HIP immediately after retrieval impaired memory in a dose-dependent fashion. However, infusions of the highest dose of PD098059 performed 40. min after retrieval enhanced memory in mice trained with a weaker footshock. These results suggest for the first time that ERK2 is involved in memory reconsolidation in a biphasic fashion. Furthermore, the inhibition of ERK could either impair or enhance mice performance depending on ERK state of activation. © 2015 IBRO.

Registro:

Documento: Artículo
Título:Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation
Autor:Krawczyk, M.C.; Blake, M.G.; Baratti, C.M.; Romano, A.; Boccia, M.M.; Feld, M.
Filiación:Laboratorio de Neurofarmacología de los Procesos de Memoria, Cátedra de Farmacología, Fac. Farmacia y Bioquímica, UBA, Argentina
Laboratorio de Neurobiología de la Memoria, Dto. Fisiología, Biología Molecular y Celular, Fac. Cs. Exactas y Naturales, UBA/IFIByNE, CONICET, Argentina
Palabras clave:ERK; Inhibitory avoidance; MAPK; Memory reconsolidation; Mice; PD098059; 2 (2 amino 3 methoxyphenyl)chromone; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase 1; animal behavior; animal experiment; animal tissue; Article; avoidance behavior; controlled study; enzyme activation; enzyme inhibition; footshock; hippocampus; inhibition kinetics; male; memory consolidation; mental task; mouse; neuromodulation; nonhuman; priority journal; task performance; animal; avoidance behavior; memory; metabolism; phosphorylation; physiology; protein processing; signal transduction; Animals; Avoidance Learning; Hippocampus; Male; MAP Kinase Signaling System; Memory; Mice; Mitogen-Activated Protein Kinase 1; Phosphorylation; Protein Processing, Post-Translational
Año:2015
Volumen:294
Página de inicio:227
Página de fin:237
DOI: http://dx.doi.org/10.1016/j.neuroscience.2015.03.019
Título revista:Neuroscience
Título revista abreviado:Neuroscience
ISSN:03064522
CODEN:NRSCD
CAS:2 (2 amino 3 methoxyphenyl)chromone, 167869-21-8; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; Mitogen-Activated Protein Kinase 1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v294_n_p227_Krawczyk

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Citas:

---------- APA ----------
Krawczyk, M.C., Blake, M.G., Baratti, C.M., Romano, A., Boccia, M.M. & Feld, M. (2015) . Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation. Neuroscience, 294, 227-237.
http://dx.doi.org/10.1016/j.neuroscience.2015.03.019
---------- CHICAGO ----------
Krawczyk, M.C., Blake, M.G., Baratti, C.M., Romano, A., Boccia, M.M., Feld, M. "Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation" . Neuroscience 294 (2015) : 227-237.
http://dx.doi.org/10.1016/j.neuroscience.2015.03.019
---------- MLA ----------
Krawczyk, M.C., Blake, M.G., Baratti, C.M., Romano, A., Boccia, M.M., Feld, M. "Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation" . Neuroscience, vol. 294, 2015, pp. 227-237.
http://dx.doi.org/10.1016/j.neuroscience.2015.03.019
---------- VANCOUVER ----------
Krawczyk, M.C., Blake, M.G., Baratti, C.M., Romano, A., Boccia, M.M., Feld, M. Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation. Neuroscience. 2015;294:227-237.
http://dx.doi.org/10.1016/j.neuroscience.2015.03.019