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Abstract:

The current research examines the influence of midazolam (MDZ) on memory reconsolidation using a contextual fear paradigm in rats, based on three context-shock training trials (0.7 mA, 3 s). First, we evaluate the effect of MDZ (1 mg/kg, i.p.) injected shortly after the training procedure. Second, we examined the influence of MDZ after a brief exposure (90 s) either in the training context (reactivation procedure) or in a neutral environment (no reactivation procedure) and one day later, freezing behavior was scored when rats were re-exposed to the training environment. Third, we investigate both the effect of MDZ administered at different times following reactivation on fear memory and the persistence of such effect 10 days after reactivation. Finally, we test whether the MDZ effect could be reverted by a single weak training trial (0.2 mA, 3 s) or by the presentation of the same unconditioned stimulus in the absence of the conditioned stimulus as a reminder which proves to induce significant freezing in rats not previously trained. Results show that MDZ interferes with the formation of a contextual fear memory only when administered after the reactivation procedure but not after the training procedure. This interference was effective up to 60 min after reactivation and not at a later time. No spontaneous recovery of freezing behavior was observed 11 days after MDZ injection which was not reverted by a weak training trial and by the unconditioned stimulus alone. All these data support the idea that stimulating GABA A receptor sites via MDZ selectively disrupts the reconsolidation process of a contextual fear memory. © 2006 IBRO.

Registro:

Documento: Artículo
Título:Midazolam disrupts fear memory reconsolidation
Autor:Bustos, S.G.; Maldonado, H.; Molina, V.A.
Filiación:Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya la Torre, Ciudad Universitaria, 5000 Córdoba, Argentina
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular, IFIBYNE-CONICET, Buenos Aires, Argentina
Palabras clave:benzodiazepine; contextual aversive conditioning; GABA-A receptors; reminder; retrograde amnesia; 4 aminobutyric acid A receptor; midazolam; benzodiazepine receptor affecting agent; midazolam; animal experiment; article; conditioning; controlled study; drug effect; environmental factor; fear; freezing; male; memory consolidation; nonhuman; photoreactivation; priority journal; rat; scoring system; stimulus response; training; animal; brain; conditioned reflex; electric shock; learning; long term memory; memory; physiology; time; Wistar rat; Animals; Association Learning; Brain; Conditioning, Classical; Electroshock; Fear; GABA Modulators; Male; Memory; Midazolam; Rats; Rats, Wistar; Retention (Psychology); Time Factors
Año:2006
Volumen:139
Número:3
Página de inicio:831
Página de fin:842
DOI: http://dx.doi.org/10.1016/j.neuroscience.2005.12.064
Título revista:Neuroscience
Título revista abreviado:Neuroscience
ISSN:03064522
CODEN:NRSCD
CAS:midazolam, 59467-70-8; GABA Modulators; Midazolam, 59467-70-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v139_n3_p831_Bustos

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Citas:

---------- APA ----------
Bustos, S.G., Maldonado, H. & Molina, V.A. (2006) . Midazolam disrupts fear memory reconsolidation. Neuroscience, 139(3), 831-842.
http://dx.doi.org/10.1016/j.neuroscience.2005.12.064
---------- CHICAGO ----------
Bustos, S.G., Maldonado, H., Molina, V.A. "Midazolam disrupts fear memory reconsolidation" . Neuroscience 139, no. 3 (2006) : 831-842.
http://dx.doi.org/10.1016/j.neuroscience.2005.12.064
---------- MLA ----------
Bustos, S.G., Maldonado, H., Molina, V.A. "Midazolam disrupts fear memory reconsolidation" . Neuroscience, vol. 139, no. 3, 2006, pp. 831-842.
http://dx.doi.org/10.1016/j.neuroscience.2005.12.064
---------- VANCOUVER ----------
Bustos, S.G., Maldonado, H., Molina, V.A. Midazolam disrupts fear memory reconsolidation. Neuroscience. 2006;139(3):831-842.
http://dx.doi.org/10.1016/j.neuroscience.2005.12.064