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Abstract:

1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. in vitro and in vivo studies revealed that CP induced but did not activate (5-aminolaevulinic acid (ALA) synthase. 3. Pretreatments with phenobarbital (PB) or SKF-525A did not modify ALA-synthase induction produced by CP. 4. Acrolein administration neither induced ALA-synthase activity nor increased cytochrome P-450 content or led to hepatic porphyrin accumulation. 5. Time course induction of cytochrome P-450 content after administration of CP or PB was similar. 6. The results obtained would indicate that CP is a strong inducer of both ALA-synthase activity and microsomal cytochrome P-450 content in liver of 17 day-old chick embryos and that its porphyrinogenic activity is not mediated by its metabolite acrolein. © 1992.

Registro:

Documento: Artículo
Título:Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo
Autor:Cochón, A.C.; de Viale, L.C.S.M.; de Calmanovici, R.W.
Filiación:Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nunez, 1428, Buenos Aires, Argentina, Argentina
Palabras clave:5 aminolevulinate synthase; acrolein; cyclophosphamide; cytochrome p450; drug metabolite; phenobarbital; porphyrin; proadifen; 5 aminolevulinate synthase; acrolein; allylisopropylacetamide; cyclophosphamide; cytochrome P450; phenobarbital; porphyrin; animal experiment; article; chick embryo; controlled study; embryo; enzyme induction; nonhuman; priority journal; animal; biosynthesis; chemical structure; chemistry; chick embryo; drug effect; enzyme induction; enzymology; gestational age; liver; metabolism; 5-Aminolevulinate Synthetase; Acrolein; Allylisopropylacetamide; Animals; Chick Embryo; Cyclophosphamide; Cytochrome P-450 Enzyme System; Enzyme Induction; Gestational Age; Liver; Molecular Structure; Phenobarbital; Porphyrins; Proadifen
Año:1992
Volumen:102
Número:1
Página de inicio:143
Página de fin:148
DOI: http://dx.doi.org/10.1016/0742-8413(92)90056-D
Título revista:Comparative Biochemistry and Physiology. Part C, Comparative
ISSN:03064492
CAS:5 aminolevulinate synthase, 9037-14-3; acrolein, 107-02-8; allylisopropylacetamide, 299-78-5; cyclophosphamide, 50-18-0; cytochrome P450, 9035-51-2; phenobarbital, 50-06-6, 57-30-7, 8028-68-0; porphyrin, 24869-67-8; proadifen, 302-33-0, 62-68-0; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Acrolein, 107-02-8; Allylisopropylacetamide, 299-78-5, 50-06-6; Cyclophosphamide, 50-18-0, 9035-51-2; Cytochrome P-450 Enzyme System, 9035-51-2; Phenobarbital, 50-06-6; Porphyrins; Proadifen, 302-33-0, 50-06-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064492_v102_n1_p143_Cochon

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Citas:

---------- APA ----------
Cochón, A.C., de Viale, L.C.S.M. & de Calmanovici, R.W. (1992) . Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo. Comparative Biochemistry and Physiology. Part C, Comparative, 102(1), 143-148.
http://dx.doi.org/10.1016/0742-8413(92)90056-D
---------- CHICAGO ----------
Cochón, A.C., de Viale, L.C.S.M., de Calmanovici, R.W. "Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo" . Comparative Biochemistry and Physiology. Part C, Comparative 102, no. 1 (1992) : 143-148.
http://dx.doi.org/10.1016/0742-8413(92)90056-D
---------- MLA ----------
Cochón, A.C., de Viale, L.C.S.M., de Calmanovici, R.W. "Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo" . Comparative Biochemistry and Physiology. Part C, Comparative, vol. 102, no. 1, 1992, pp. 143-148.
http://dx.doi.org/10.1016/0742-8413(92)90056-D
---------- VANCOUVER ----------
Cochón, A.C., de Viale, L.C.S.M., de Calmanovici, R.W. Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo. 1992;102(1):143-148.
http://dx.doi.org/10.1016/0742-8413(92)90056-D