Artículo
García, S.C.; Moretti, M.B.; Garay, M.V.R.; Batlle, A. "δ-Aminolevulinic acid transport through blood-brain barrier" (1998) General Pharmacology. 31(4):579-582
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Abstract:
δ-Aminolevulinic acid (ALA) and γ-aminobutyric acid (GABA) transport through the rat blood-brain barrier (BBB) was studied.GABA transport (K(m)=3.2±0.1 μM and V(max)=0.299±0.045 μmol/mg protein min) is probably mediated by a permease similar to Saccharomyces cerevisise PUT4; this result also indicates that the isolated capillaries are metabolically active.ALA incorporation into rat brain endothelial cells is not detected even in capillaries treated to expose the luminal surface.Previous evidence indicates that ALA can cross the BBB from blood to brain; so we conclude that, with the methodology used here, transport in the luminal membrane of the capillaries cannot be investigated. Copyright (C) 1998 Elsevier Science Inc.
Registro:
| Documento: | Artículo |
| Título: | δ-Aminolevulinic acid transport through blood-brain barrier |
| Autor: | García, S.C.; Moretti, M.B.; Garay, M.V.R.; Batlle, A. |
| Filiación: | Ctro. de Invest. Sobre Porfirinas Y., CIPYP (CONICET, FCEyN, UBA), Cd. U., Buenos Aires, Argentina |
| Palabras clave: | γ-Aminobutyric acid; δ-Aminolevulinic acid; Biological transport; Blood-brain barrier; PUT4 permease; UGA4 permease; 2 amino 2 methylpropionic acid; 4 aminobutyric acid; acexamic acid; aminolevulinic acid; beta alanine; carrier protein; leucine; ouabain; proline; 4 aminobutyric acid uptake; animal tissue; article; blood brain barrier; drug transport; endothelium cell; male; nonhuman; priority journal; rat; transport at the cellular level; Aminolevulinic Acid; Animals; Blood-Brain Barrier; Capillary Permeability; gamma-Aminobutyric Acid; Male; Rats; Rats, Sprague-Dawley |
| Año: | 1998 |
| Volumen: | 31 |
| Número: | 4 |
| Página de inicio: | 579 |
| Página de fin: | 582 |
| DOI: | http://dx.doi.org/10.1016/S0306-3623(98)00038-X |
| Título revista: | General Pharmacology |
| Título revista abreviado: | Gen. Pharmacol. |
| ISSN: | 03063623 |
| CODEN: | GEPHD |
| CAS: | Aminolevulinic Acid, 106-60-5; gamma-Aminobutyric Acid, 56-12-2 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v31_n4_p579_Garcia |
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Citas:
---------- APA ----------
García, S.C., Moretti, M.B., Garay, M.V.R. & Batlle, A. (1998) . δ-Aminolevulinic acid transport through blood-brain barrier. General Pharmacology, 31(4), 579-582.http://dx.doi.org/10.1016/S0306-3623(98)00038-X
---------- CHICAGO ----------
García, S.C., Moretti, M.B., Garay, M.V.R., Batlle, A. "δ-Aminolevulinic acid transport through blood-brain barrier" . General Pharmacology 31, no. 4 (1998) : 579-582.http://dx.doi.org/10.1016/S0306-3623(98)00038-X
---------- MLA ----------
García, S.C., Moretti, M.B., Garay, M.V.R., Batlle, A. "δ-Aminolevulinic acid transport through blood-brain barrier" . General Pharmacology, vol. 31, no. 4, 1998, pp. 579-582.http://dx.doi.org/10.1016/S0306-3623(98)00038-X
---------- VANCOUVER ----------
García, S.C., Moretti, M.B., Garay, M.V.R., Batlle, A. δ-Aminolevulinic acid transport through blood-brain barrier. Gen. Pharmacol. 1998;31(4):579-582.http://dx.doi.org/10.1016/S0306-3623(98)00038-X
