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Abstract:

1. Male CF 1 mice were fed p-dimethylaminoazobenzene (DAB) for 35 days and received 5,5 diethylbarbituric acid, before or after DAB treatment, with the purpose of investigating whether the onset of the preinitiation stage of carcinogenesis alters the natural regulatory mechanism of the heme pathway. 2. Changes detected in drug metabolizing enzymes are likely to be the consequence of a primary deregulation mechanism of heme metabolism, shown by an increase in 6 aminolevulinic acid synthetase activity and a decrease in microsomal heme oxygenase, which would finally lead to a great enhancement of cytochrome P450 levels. 3. The alterations found here would give rise to a pattern distinctive to that usually observed in the so called resistant hepatocyte.

Registro:

Documento: Artículo
Título:Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal
Autor:Gerez, E.; Vazquez, E.; Caballero, F.; Polo, C.; Batlle, A.
Filiación:Ctro. Invest. Sobre Porfirinas Y P., (CONICET-FCEN, UBA), Cd. Univ., Buenos Aires, Argentina
Palabras clave:Azo-dye; Drug metabolizing enzyme system; Heme metabolism; Hepatocarcinogenesis; Porphyrinogen drug; 4 dimethylaminoazobenzene; 5 aminolevulinate synthase; barbital; cytochrome p450; heme oxygenase; animal model; animal tissue; article; controlled study; enzyme activity; heme synthesis; liver carcinogenesis; male; mouse; nonhuman; priority journal
Año:1997
Volumen:29
Número:4
Página de inicio:569
Página de fin:573
DOI: http://dx.doi.org/10.1016/S0306-3623(96)00574-5
Título revista:General Pharmacology
Título revista abreviado:GEN. PHARMACOL.
ISSN:03063623
CODEN:GEPHD
CAS:4 dimethylaminoazobenzene, 60-11-7; 5 aminolevulinate synthase, 9037-14-3; barbital, 144-02-5, 57-44-3; cytochrome P450, 9035-51-2; heme oxygenase, 9059-22-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v29_n4_p569_Gerez

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Citas:

---------- APA ----------
Gerez, E., Vazquez, E., Caballero, F., Polo, C. & Batlle, A. (1997) . Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal. General Pharmacology, 29(4), 569-573.
http://dx.doi.org/10.1016/S0306-3623(96)00574-5
---------- CHICAGO ----------
Gerez, E., Vazquez, E., Caballero, F., Polo, C., Batlle, A. "Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal" . General Pharmacology 29, no. 4 (1997) : 569-573.
http://dx.doi.org/10.1016/S0306-3623(96)00574-5
---------- MLA ----------
Gerez, E., Vazquez, E., Caballero, F., Polo, C., Batlle, A. "Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal" . General Pharmacology, vol. 29, no. 4, 1997, pp. 569-573.
http://dx.doi.org/10.1016/S0306-3623(96)00574-5
---------- VANCOUVER ----------
Gerez, E., Vazquez, E., Caballero, F., Polo, C., Batlle, A. Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal. GEN. PHARMACOL. 1997;29(4):569-573.
http://dx.doi.org/10.1016/S0306-3623(96)00574-5