Artículo

Polo, C.F.; Buzaleh, A.M.; Vazquez, E.S.; Afonso, S.G.; Navone, N.M.; Del Carmen Batlle, A.M. "Griseofulvin-induced hepatopathy due to abnormalities in heme pathways" (1997) General Pharmacology. 29(2):207-210
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Abstract:

1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) increase of direct bilirubin values after 7 days of treatment; hepatic injury was confirmed by measuring a g fold increase of free bilirubin. 4. Enhanced values of alkaline phosphatase and glutamic oxalacetic transaminase (GOT) confirmed the onset of cholestasis. 5. Topical application of GRIS induced measurable hepatopathy. Nevertheless, we cannot discard the possibility that this hepatopathy could also be attributed in part to a direct reaction to xenobiotics.

Registro:

Documento: Artículo
Título:Griseofulvin-induced hepatopathy due to abnormalities in heme pathways
Autor:Polo, C.F.; Buzaleh, A.M.; Vazquez, E.S.; Afonso, S.G.; Navone, N.M.; Del Carmen Batlle, A.M.
Filiación:Natl. Res. Ctr. Porphyrins P., FCEN (UBA), CONICET, Buenos Aires, Argentina
Palabras clave:Cholestasis; Griseofulvan; Heme pathway; Hepatopathy; alkaline phosphatase; aspartate aminotransferase; bilirubin; bilirubin glucuronide; griseofulvin; heme; porphyrin; xenobiotic agent; animal experiment; animal tissue; article; cholestasis; controlled study; liver disease; liver injury; liver level; long term exposure; male; microscopy; mouse; nonhuman; priority journal; topical drug administration; Administration, Topical; Animals; Antibiotics, Antifungal; Biological Markers; Griseofulvin; Heme; Liver; Liver Function Tests; Male; Mice
Año:1997
Volumen:29
Número:2
Página de inicio:207
Página de fin:210
DOI: http://dx.doi.org/10.1016/S0306-3623(96)00406-5
Título revista:General Pharmacology
Título revista abreviado:GEN. PHARMACOL.
ISSN:03063623
CODEN:GEPHD
CAS:Antibiotics, Antifungal; Biological Markers; Griseofulvin, 126-07-8; Heme, 14875-96-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v29_n2_p207_Polo

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Citas:

---------- APA ----------
Polo, C.F., Buzaleh, A.M., Vazquez, E.S., Afonso, S.G., Navone, N.M. & Del Carmen Batlle, A.M. (1997) . Griseofulvin-induced hepatopathy due to abnormalities in heme pathways. General Pharmacology, 29(2), 207-210.
http://dx.doi.org/10.1016/S0306-3623(96)00406-5
---------- CHICAGO ----------
Polo, C.F., Buzaleh, A.M., Vazquez, E.S., Afonso, S.G., Navone, N.M., Del Carmen Batlle, A.M. "Griseofulvin-induced hepatopathy due to abnormalities in heme pathways" . General Pharmacology 29, no. 2 (1997) : 207-210.
http://dx.doi.org/10.1016/S0306-3623(96)00406-5
---------- MLA ----------
Polo, C.F., Buzaleh, A.M., Vazquez, E.S., Afonso, S.G., Navone, N.M., Del Carmen Batlle, A.M. "Griseofulvin-induced hepatopathy due to abnormalities in heme pathways" . General Pharmacology, vol. 29, no. 2, 1997, pp. 207-210.
http://dx.doi.org/10.1016/S0306-3623(96)00406-5
---------- VANCOUVER ----------
Polo, C.F., Buzaleh, A.M., Vazquez, E.S., Afonso, S.G., Navone, N.M., Del Carmen Batlle, A.M. Griseofulvin-induced hepatopathy due to abnormalities in heme pathways. GEN. PHARMACOL. 1997;29(2):207-210.
http://dx.doi.org/10.1016/S0306-3623(96)00406-5