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Abstract:

1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was also enhanced, but these values were lower when animals also received PB. 3. Cytochrome (CYT) P-450 levels were enhanced in animals treated with enflurane whether or not they were given PB. 4. Gluthatione-S-transferase activity was induced by enflurane (138%) or isoflurane (174%), and even more in animals receiving PB also. Sulfatase activity was increased more than 60% with anesthetics. Isoflurane produced a 50% increase of β-glucuronidase activity and a 35% diminution of tryptophan pyrrolase. 5. The association between anesthetics and PB produced diverse effects on the metabolizing enzyme system. 6. Data suggest that both anesthetics, chemically related, could act through two different mechanisms, however, with the same final effect: heme pathway deregulation.

Registro:

Documento: Artículo
Título:Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
Autor:Buzaleh, A.M.; Vazquez, E.S.; Nuñez, G.; Batlle, A.M.D.C.
Filiación:Ctro. Invest. Sobre Porfirinas/P., Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina
Viamonte 1881 10 A, 1056 Buenos Aires, Argentina
Palabras clave:Chronic anesthesia; Drug-metabolizing enzyme system; Enflurane; Heme metabolism; Isoflurane; 5 aminolevulinate synthase; beta glucuronidase; cytochrome p450; enflurane; glutathione transferase; isoflurane; phenobarbital; sulfatase; tryptophan 2,3 dioxygenase; anesthesia; animal experiment; article; drug metabolism; enzyme activity; male; mouse; nonhuman; priority journal; 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Anesthetics, Inhalation; Animals; Cytochrome P-450 Enzyme System; Enflurane; Heme; Hypnotics and Sedatives; Isoflurane; Liver; Male; Mice; Phenobarbital; Porphobilinogen; Porphyrins
Año:1997
Volumen:28
Número:4
Página de inicio:577
Página de fin:582
DOI: http://dx.doi.org/10.1016/S0306-3623(96)00245-5
Título revista:General Pharmacology
Título revista abreviado:GEN. PHARMACOL.
ISSN:03063623
CODEN:GEPHD
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Aminolevulinic Acid, 106-60-5; Anesthetics, Inhalation; Cytochrome P-450 Enzyme System, 9035-51-2; Enflurane, 13838-16-9; Heme, 14875-96-8; Hypnotics and Sedatives; Isoflurane, 26675-46-7; Phenobarbital, 50-06-6; Porphobilinogen, 487-90-1; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v28_n4_p577_Buzaleh

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Citas:

---------- APA ----------
Buzaleh, A.M., Vazquez, E.S., Nuñez, G. & Batlle, A.M.D.C. (1997) . Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation. General Pharmacology, 28(4), 577-582.
http://dx.doi.org/10.1016/S0306-3623(96)00245-5
---------- CHICAGO ----------
Buzaleh, A.M., Vazquez, E.S., Nuñez, G., Batlle, A.M.D.C. "Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation" . General Pharmacology 28, no. 4 (1997) : 577-582.
http://dx.doi.org/10.1016/S0306-3623(96)00245-5
---------- MLA ----------
Buzaleh, A.M., Vazquez, E.S., Nuñez, G., Batlle, A.M.D.C. "Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation" . General Pharmacology, vol. 28, no. 4, 1997, pp. 577-582.
http://dx.doi.org/10.1016/S0306-3623(96)00245-5
---------- VANCOUVER ----------
Buzaleh, A.M., Vazquez, E.S., Nuñez, G., Batlle, A.M.D.C. Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation. GEN. PHARMACOL. 1997;28(4):577-582.
http://dx.doi.org/10.1016/S0306-3623(96)00245-5