Artículo
Buzaleh, A.M.; Del Carmen Batlle, A.M. "Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice" (1996) General Pharmacology. 27(6):1009-1012
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Abstract:
The influence of strain and sex on the effect of enflurane and isoflurane administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. Enflurane produced 35% and 80% increases in ALA-S activity only in CF1 male and female mice, respectively, whereas isoflurane induced 40% enzyme activity in CF1 male. CF1 males showed around 35% decrease in blood PBGase and PBG-deaminase after administration of enflurane, whereas isoflurane provoked a striking inhibition (70%) in males of the C57 strain. Enflurane produced alterations in heme synthesis, which would fit a model of acute porphyria in CF1 male mice. On the other hand, isoflurane would mimic biochemical alterations of this porphyria in C57 males.
Registro:
| Documento: | Artículo |
| Título: | Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice |
| Autor: | Buzaleh, A.M.; Del Carmen Batlle, A.M. |
| Filiación: | Centro de Investigaciones Sobre P., CONICET-FCEN, UBA, Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina Viamonte 1881 10o A, 1056 Buenos Aires, Argentina |
| Palabras clave: | acute intermittent porphyria; enflurane; heme metabolism; isoflurane; sex; strain; 5 aminolevulinate synthase; enflurane; heme; isoflurane; porphobilinogen deaminase; porphobilinogen synthase; acute intermittent porphyria; animal experiment; animal model; article; controlled study; enzyme activity; enzyme blood level; female; heme synthesis; intraperitoneal drug administration; male; metabolism; mouse; nonhuman; priority journal; sex difference; strain difference |
| Año: | 1996 |
| Volumen: | 27 |
| Número: | 6 |
| Página de inicio: | 1009 |
| Página de fin: | 1012 |
| DOI: | http://dx.doi.org/10.1016/0306-3623(95)02137-X |
| Título revista: | General Pharmacology |
| Título revista abreviado: | GEN. PHARMACOL. |
| ISSN: | 03063623 |
| CODEN: | GEPHD |
| CAS: | 5 aminolevulinate synthase, 9037-14-3; enflurane, 13838-16-9; heme, 14875-96-8; isoflurane, 26675-46-7; porphobilinogen deaminase, 9036-47-9, 9074-91-3; porphobilinogen synthase, 9036-37-7 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v27_n6_p1009_Buzaleh |
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Citas:
---------- APA ----------
Buzaleh, A.M. & Del Carmen Batlle, A.M. (1996) . Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice. General Pharmacology, 27(6), 1009-1012.http://dx.doi.org/10.1016/0306-3623(95)02137-X
---------- CHICAGO ----------
Buzaleh, A.M., Del Carmen Batlle, A.M. "Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice" . General Pharmacology 27, no. 6 (1996) : 1009-1012.http://dx.doi.org/10.1016/0306-3623(95)02137-X
---------- MLA ----------
Buzaleh, A.M., Del Carmen Batlle, A.M. "Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice" . General Pharmacology, vol. 27, no. 6, 1996, pp. 1009-1012.http://dx.doi.org/10.1016/0306-3623(95)02137-X
---------- VANCOUVER ----------
Buzaleh, A.M., Del Carmen Batlle, A.M. Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice. GEN. PHARMACOL. 1996;27(6):1009-1012.http://dx.doi.org/10.1016/0306-3623(95)02137-X
