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Abstract:

1. 1. The effect of enflurane or isoflurane anesthesia (1 ml/kg, i.p.) in animals chronically treated with ethanol (30%, v/v, in drinking water during a week) on heme metabolism and its regulation was investigated. 2. 2. In those animals previously intoxicated with ethanol that received isoflurane, ALA-S activity was increased (control values: 0.071 ± 0.022 nmol/mg, n = 10; treated animals: 0.110 ± 0.034 nmol/mg, n = 8) and blood PBGase and deaminase were strikingly diminished (control values, n = 10: PBGase: 0.101 ± 0.015 nmol/mg, deaminase: 0.242 ± 0.075 nmol/mg; treated animals, n = 6: PBGase: 0.063 ± 0.013 nmol/mg; deaminase: 0.145 ± 0.045 nmol/mg). 3. 3. The time-response study showed that liver ALA-S is enhanced at shorter times of anesthesia with isoflurane and that blood PBGase and deaminase appeared inhibited later in animals previously treated with ethanol. 4. 4. Results reproduce some biochemical alterations known to occur in acute intermittent porphyria. © 1995.

Registro:

Documento: Artículo
Título:Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption
Autor:Buzaleh, A.M.; Vazquez, E.S.; Del C. Batlle, A.M.
Filiación:Centro de Investigaciones sobre, Porfirinas y Porfirias (CIPYP)-(CONICET-FCEN, UBA). Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina
Palabras clave:acute intermittent porphyria; aminolevulinic acid synthetase; Enflurane; ethanol; heme metabolism; heme oxygenase; isoflurane; porfobilinogen deaminase; porfobilinogenase; rhodanese; 5 aminolevulinate synthase; deaminase; enflurane; isoflurane; organofluorine derivative; porphobilinogenase; unclassified drug; acute intermittent porphyria; alcohol consumption; anesthesia; animal model; article; blood; controlled study; drug efficacy; intraperitoneal drug administration; liver; male; metabolic regulation; mouse; nonhuman; priority journal; Animal; Enflurane; Ethanol; Ethers; Heme; Liver; Male; Mice; Mice, Inbred Strains; Support, Non-U.S. Gov't; Time Factors
Año:1995
Volumen:26
Número:6
Página de inicio:1425
Página de fin:1429
DOI: http://dx.doi.org/10.1016/0306-3623(94)00305-7
Título revista:General Pharmacology
Título revista abreviado:Gen. Pharmacol. Vasc. Syst.
ISSN:03063623
CODEN:GEPHD
CAS:5 aminolevulinate synthase, 9037-14-3; deaminase, 9067-84-9; enflurane, 13838-16-9; isoflurane, 26675-46-7; porphobilinogenase, 9055-40-7; Enflurane, 13838-16-9; Ethanol, 64-17-5; Ethers; Heme, 14875-96-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v26_n6_p1425_Buzaleh

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Citas:

---------- APA ----------
Buzaleh, A.M., Vazquez, E.S. & Del C. Batlle, A.M. (1995) . Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption. General Pharmacology, 26(6), 1425-1429.
http://dx.doi.org/10.1016/0306-3623(94)00305-7
---------- CHICAGO ----------
Buzaleh, A.M., Vazquez, E.S., Del C. Batlle, A.M. "Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption" . General Pharmacology 26, no. 6 (1995) : 1425-1429.
http://dx.doi.org/10.1016/0306-3623(94)00305-7
---------- MLA ----------
Buzaleh, A.M., Vazquez, E.S., Del C. Batlle, A.M. "Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption" . General Pharmacology, vol. 26, no. 6, 1995, pp. 1425-1429.
http://dx.doi.org/10.1016/0306-3623(94)00305-7
---------- VANCOUVER ----------
Buzaleh, A.M., Vazquez, E.S., Del C. Batlle, A.M. Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption. Gen. Pharmacol. Vasc. Syst. 1995;26(6):1425-1429.
http://dx.doi.org/10.1016/0306-3623(94)00305-7