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Abstract:

1. The effect of the administration of several doses of Enflurane and Isoflurane (2 ml/kg, i.p., daily) on heme metabolism and glucose levels was studied. 2. Liver and kidney δ-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead induction of this enzyme was only detected, in animals receiving one dose of Isoflurane. 3. Blood Porphobilinogenase and deaminase (50%, P < 0.01) inhibition was produced only when animals received a single dose of the anesthetics. 5. ALA-S induction observed after the third dose of anesthetics could be a consequence of long lasting depletion in heme synthesis produced by blocking at uroporphyrinogen level. © 1994.

Registro:

Documento: Artículo
Título:Effect of multiple doses of volatile anesthetics on heme enzymes
Autor:Buzaleh, A.M.; Enriquez de Salamanca, R.; Del Batlle, C.A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP)-(CONICET-FCEN, UBA), Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina [Fax 54-1-811-7447]
Unidad de Porfirias, Departamento de Medicina Interna, Hospital Universitario Doce de Octubre, Madrid, Spain
Palabras clave:acute porphyrias; anesthetics; Heme enzymes; porphyrinogenic drugs; 5 aminolevulinate synthase; enflurane; glucose; inhalation anesthetic agent; isoflurane; liver enzyme; porphobilinogen deaminase; porphobilinogenase; unclassified drug; uroporphyrinogen; acute intermittent porphyria; animal experiment; animal tissue; article; controlled study; enzyme activity; enzyme blood level; enzyme induction; heme synthesis; intraperitoneal drug administration; mouse; nonhuman; priority journal; 5-Aminolevulinate Synthetase; Ammonia-Lyases; Animal; Dose-Response Relationship, Drug; Enflurane; Glucose; Heme; Isoflurane; Kidney; Liver; Mice; Mice, Inbred Strains; Support, Non-U.S. Gov't
Año:1994
Volumen:25
Número:6
Página de inicio:1179
Página de fin:1183
DOI: http://dx.doi.org/10.1016/0306-3623(94)90135-X
Título revista:General Pharmacology
Título revista abreviado:Gen. Pharmacol. Vasc. Syst.
ISSN:03063623
CODEN:GEPHD
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Ammonia-Lyases, EC 4.3.1.; Enflurane, 13838-16-9; Glucose, 50-99-7; Heme, 14875-96-8; Isoflurane, 26675-46-7; porphobilinogenase, EC 5.-
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v25_n6_p1179_Buzaleh

Referencias:

  • Batlle, Wider de Xifra, Stella, A simple method for measuring erythrocyte porphobilinogenase and its use in the diagnosis of acute intermittent porphyria (1978) Int. J. Biochem., 9, pp. 871-875
  • Brodie, Moore, Goldberg, Enzyme abnormalities in the Porphyrias (1977) Lancet, 2, pp. 699-701
  • Buzaleh, Enriquez de Salamanca, Batlle, Porphyrinogenic properties of the anesthetic Enflurane (1992) Gen. Pharmac., 23, pp. 665-669
  • Buzaleh, Enriquez de Salamanca, Batlle, Administration of the anesthetic Isoflurane to mice: a model for Acute Intermittent Porphyria? (1992) J. Pharmacol. Toxicol. Meth., 28, pp. 191-197
  • Granick, The induction in vitro of the synthesis of δ-aminolevulinic acid synthetase in chemical porphyria, a response to certain drugs, sex hormones, and foreign chemicals (1966) J. biol. Chem., 241, pp. 1359-1375
  • Granick, Urata, Increase in activity of δ-aminolevulinic acid synthetase in liver mitochondria induced by feeding of 3,5-dicarbetoxy-1,4-dihydrocollidine (1963) J. biol. Chem., 238, pp. 821-827
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin-phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Marver, Tschudy, Perlroth, Collins, δ-Aminolevulinic acid synthetase I. Studies in liver homogenates (1966) J. biol. Chem., 241, pp. 2803-2809
  • Mauzerall, Granick, The occurrence and determination of δ-aminolevulinic acid and porphobilinogen in urine (1956) J. biol. Chem., 219, pp. 435-446
  • Murphy, Acute Intermittent Porphyria (1964) The anesthetic problem and its background, 36, pp. 801-812. , Br. J. Anaesth
  • Parikh, Moore, Effect of certain anaesthetic agents on the activity of rat hepatic δ-aminolaevulinate synthase (1978) Br. J. Anaesth., 50, pp. 1099-1103
  • Quail, Modern inhalation anaesthetic agents (1989) A review of halothane, isoflurane and enflurane, 150, pp. 95-102. , Med. J. Austr
  • Strand, Felscher, Redeker, Marver, Enzymatic abnormality in heme biosynthesis in acute intermittent porphyria: decreased hepatic conversion of porphobilinogen to porphyrins and increased δ-aminolevulinic acid synthetase activity (1970) Proc. Natn. Acad. Sci. U.S.A., 67, pp. 1315-1320
  • Tenhunen, Marver, Schmid, The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin (1970) J. Lab. Clin. Med., 75, pp. 410-421
  • Ziman, Bradshaw, Ivanetich, The effect of fluoroxene [(2,2,2-trifluoroethoxy)ethane] on haem biosynthesis and degradation (1980) Biochem. J., 190, pp. 571-580

Citas:

---------- APA ----------
Buzaleh, A.M., Enriquez de Salamanca, R. & Del Batlle, C.A.M. (1994) . Effect of multiple doses of volatile anesthetics on heme enzymes. General Pharmacology, 25(6), 1179-1183.
http://dx.doi.org/10.1016/0306-3623(94)90135-X
---------- CHICAGO ----------
Buzaleh, A.M., Enriquez de Salamanca, R., Del Batlle, C.A.M. "Effect of multiple doses of volatile anesthetics on heme enzymes" . General Pharmacology 25, no. 6 (1994) : 1179-1183.
http://dx.doi.org/10.1016/0306-3623(94)90135-X
---------- MLA ----------
Buzaleh, A.M., Enriquez de Salamanca, R., Del Batlle, C.A.M. "Effect of multiple doses of volatile anesthetics on heme enzymes" . General Pharmacology, vol. 25, no. 6, 1994, pp. 1179-1183.
http://dx.doi.org/10.1016/0306-3623(94)90135-X
---------- VANCOUVER ----------
Buzaleh, A.M., Enriquez de Salamanca, R., Del Batlle, C.A.M. Effect of multiple doses of volatile anesthetics on heme enzymes. Gen. Pharmacol. Vasc. Syst. 1994;25(6):1179-1183.
http://dx.doi.org/10.1016/0306-3623(94)90135-X