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Abstract:

1. 1. The effect of enflurane, a volatile anesthetic, on heme metabolism was studied. Different doses (0.5-6.0 ml/kg) of this anesthetic were administered i.p. to mice and animals sacrificed at different times after administration (5-240 min). 2. 2. The dose of 2 ml/kg was chosen as the optimum anesthetic dose producing more alterations in the heme pathway. 3. 3. ALA-S was significantly induced at earlier times of anesthesia. 4. 4. Blood PBGase and deaminase was greatly reduced. 5. 5. This diminution coupled with ALA-S induction are in accordance with the known biochemical changes occurring in acute intermittent porphyria and include enflurane in the list of porphyrinogenic drugs, the use of which is not recommended for the management of anesthesia in porphyric patients. © 1992.

Registro:

Documento: Artículo
Título:Porphyrinogenic properties of the anesthetic enflurane
Autor:Buzaleh, A.M.; de Salamanca, R.E.; del C. Batlle, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas v Porfirias (CIPYP), (CONICET-FCEN, UBA), Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina
Unidad de Porfirias, Departamento de Medicina Interna, Hospital Climco de San Carlos, Madrid, Spain
Palabras clave:5 aminolevulinate synthase; anesthetic agent; deaminase; enflurane; heme; animal experiment; animal tissue; article; controlled study; dose time effect relation; enzyme activity; heme synthesis; intraperitoneal drug administration; kidney; liver; metabolism; mouse; nonhuman; porphyria; priority journal; 5-Aminolevulinate Synthetase; Ammonia-Lyases; Animal; Blood Glucose; Enflurane; Glucose; Heme; Kidney; Liver; Mice; Porphyrins; Support, Non-U.S. Gov't
Año:1992
Volumen:23
Número:4
Página de inicio:665
Página de fin:669
DOI: http://dx.doi.org/10.1016/0306-3623(92)90145-A
Título revista:General Pharmacology
Título revista abreviado:Gen. Pharmacol. Vasc. Syst.
ISSN:03063623
CODEN:GEPHD
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Ammonia-Lyases, EC 4.3.1.; Blood Glucose; Enflurane, 13838-16-9; Glucose, 50-99-7; Heme, 14875-96-8; porphobilinogenase, EC 5.-; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v23_n4_p665_Buzaleh

Referencias:

  • Batlle, Rossetti, Enzymic polymerization of porphobilinogen into uroporphyrinogens (1977) Int. J. Biochem., 8, pp. 1-12
  • Batlle, Wider de Xifra, Stella, A simple method for measuring erythrocyte porphobilinogenase and its use in the diagnosis of acute intermittent porphyria (1978) Int. J. Biochem., 9, pp. 871-875
  • Brunner, Passonneau, Molstad, The effect of volatile anesthetics on levels of metabolites and on metabolic rate in brain (1971) J. Neurochem., 18, pp. 2301-2316
  • Doss, Verspohl, The “glucose effect” in acute hepatic porphyrias and in experimental porphyria (1981) Klin. Wschr., 59, pp. 727-735
  • Granick, The induction in vitro of the synthesis of δ-aminolevulinic acid synthetase in chemical porphyria, a response to certain drugs, sex hormones, and foreign chemicals (1966) J. biol. Chem., 241, pp. 1359-1375
  • Granick, Urata, Increase in activity of δ-amino-levulinic acid synthetase in liver mitochondria induced by feeding of 3,5-decarbetoxy-1,4-dehydrocollidine (1963) J. biol. Chem., 238, pp. 821-827
  • Kappas, Sassa, Anderson, (1983) The Porphyrias in The Metabolic Basis of Inherited Disease, pp. 1301-1384. , McGraw Hill, New York
  • Kofke, Hawkins, Davis, Biebuyck, Phil, Comparison of the effects of volatile anesthetics on brain glucose metabolism in rats (1987) Anesthesiology, 6, pp. 810-813
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin-phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Marver, Tschudy, Perlroth, Collins, δ-Aminolevulinic acid synthetase I. Studies in liver homogenates (1966) J. biol. Chem., 241, pp. 2803-2809
  • Mauzerall, Granick, The occurrence and determination of δ-aminolevulinic acid and porphobilinogen in urine (1956) J. biol. Chem., 219, pp. 435-446
  • Polo, Navone, Afonso, Buzaleh, Schoua, Vázquez, Batlle, Allylisopropyl-acetamide and glycerine reproduce clinical and biochemical manifestations of acute intermittent porphyria in mice (1987) Med. Sci. Res., 15, pp. 1335-1336
  • Strand, Felscher, Redeker, Marver, Enzymatic abnormality in heme biosynthesis in acute intermittent porphyria: decreased hepatic conversion of porphobilinogen to porphyrins and increased δ-aminolevulinic acid synthetase activity (1970) Proc. Natn. Acad. Sci. U.S.A., 67, pp. 1315-1320
  • Tenhunen, Marver, Schmid, The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase (1968) Proc. Natn. Acad. Sci. U.S.A., 61, pp. 748-760
  • Tenhunen, Marver, Schmid, The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin (1970) J. Lab. clin. Med., 75, pp. 410-421
  • Tschudy, Welland, Collins, Hunter, Jr, The effect of carbohydrate feeding on the induction of δ-amino-levulinic acid synthetase (1964) Metabolism, 13, pp. 396-406
  • Yoda, Schacter, Israels, Induction of δ-aminolevulinic acid synthetase in the kidney of chickens treated with porphyrinogenic drugs (1974) Biochim. biophys. Acta, 372, pp. 478-481
  • Ziman, Bradshaw, Ivanetich, The effect of fluoroxene [(2,2,2-trifluoroethoxy)ethane] on haem biosynthesis and degradation (1980) Biochem. J., 190, pp. 571-580

Citas:

---------- APA ----------
Buzaleh, A.M., de Salamanca, R.E. & del C. Batlle, A.M. (1992) . Porphyrinogenic properties of the anesthetic enflurane. General Pharmacology, 23(4), 665-669.
http://dx.doi.org/10.1016/0306-3623(92)90145-A
---------- CHICAGO ----------
Buzaleh, A.M., de Salamanca, R.E., del C. Batlle, A.M. "Porphyrinogenic properties of the anesthetic enflurane" . General Pharmacology 23, no. 4 (1992) : 665-669.
http://dx.doi.org/10.1016/0306-3623(92)90145-A
---------- MLA ----------
Buzaleh, A.M., de Salamanca, R.E., del C. Batlle, A.M. "Porphyrinogenic properties of the anesthetic enflurane" . General Pharmacology, vol. 23, no. 4, 1992, pp. 665-669.
http://dx.doi.org/10.1016/0306-3623(92)90145-A
---------- VANCOUVER ----------
Buzaleh, A.M., de Salamanca, R.E., del C. Batlle, A.M. Porphyrinogenic properties of the anesthetic enflurane. Gen. Pharmacol. Vasc. Syst. 1992;23(4):665-669.
http://dx.doi.org/10.1016/0306-3623(92)90145-A