Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

1. A clear biphasic response of the enzyme activities as a function of intoxication time due to the topical cutaneous griseofulvin treatment was observed. 2. The initial acute induction of ALA-S activity would be due to depletion of free heme in the regulatory pool caused by cytochrome P 450 destruction. 3. The second induction peak, would be due to less heme formation, secondary to the ferrochelatase inhibition, as expected for the erythropoietic protoporphyria model. 4. The biphasic response of hepatic ALA-D and PBGase activities would be related to ALA-S activity changes and the subsequent augmented available substrates. 5. Endogenous liver porphyrin distribution in cytosolic, mitochondrial and nuclear fractions was investigated. 6. The in vitro biosynthesis of porphyrins confirmed both the biphasic model and the hepatic porphyrins subcellular distribution. 7. Two mechanisms to explain the action of griseofulvin at shorter and longer times of intoxication are proposed. © 1991.

Registro:

Documento: Artículo
Título:The effect of griseofulvin on the heme pathway-II. An exhaustive analysis during short and long-term challenge
Autor:Navone, N.M.; Buzaleh, A.M.; Polo, C.F.; Afonso, S.G.; Vázquez, E.S.; del C. Batlle, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), (CONICET-FCEN, UBA), Ciudad Universitaria, Pabellon II, 2 do Piso, 1428 Buenos Aires, Argentina
Palabras clave:5 aminolevulinate synthase; griseofulvin; porphobilinogen deaminase; porphobilinogen synthase; porphobilinogenase; porphyrin; unclassified drug; uroporphyrinogen iii synthase; animal experiment; animal tissue; article; enzyme activity; heme synthesis; liver; male; metabolism; mouse; nonhuman; oral drug administration; porphyria; priority journal; tissue culture; 5-Aminolevulinate Synthetase; Ammonia-Lyases; Animal; Cell Nucleus; Cytochrome P-450 Enzyme System; Cytosol; Griseofulvin; Heme; In Vitro; Liver; Male; Mice; Mitochondria, Liver; Porphobilinogen Synthase; Porphyrins; Proteins; Support, Non-U.S. Gov't
Año:1991
Volumen:22
Número:6
Página de inicio:1179
Página de fin:1183
DOI: http://dx.doi.org/10.1016/0306-3623(91)90598-Z
Título revista:General Pharmacology
Título revista abreviado:Gen. Pharmacol. Vasc. Syst.
ISSN:03063623
CODEN:GEPHD
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Ammonia-Lyases, EC 4.3.1.; Cytochrome P-450 Enzyme System, 9035-51-2; Griseofulvin, 126-07-8; Heme, 14875-96-8; Porphobilinogen Synthase, EC 4.2.1.24; porphobilinogenase, EC 5.-; Porphyrins; Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v22_n6_p1179_Navone

Referencias:

  • Batlle, Ferramola, Grinstein, Purification and general properties of δ-aminolevulinate dehydratase from cow liver (1967) Biochem. J., 104, pp. 244-249
  • Batlle, Wider de Xifra, Stella, A simple method for measuring erythrocyte porphobilinogenase, and its use in the diagnosis of acute intermittent porphyria (1978) International Journal of Biochemistry, 9, pp. 871-875
  • Cantoni, Di Padova, Rovagnati, Ruggieri, Dalfiume, Tritapep, Bile secretion and liver microsomal mixed function oxidase system in mice with griseofulvin-induced hepatic protoporphyria (1983) Toxicology, 27, pp. 27-39
  • De Matteis, Hepatic porphyrias caused by 2-allyl-2-isopropylacetamide, 3,5-diethoxycarbonyl-1,4-dihydrocollidine, griseofulvin and related compounds (1978) Handbook of Experimental Pharmacology, 44, pp. 129-155. , F. De Matteis, W.N. Aldridge, Springer, Berlin
  • De Matteis, Gibbs, Stimulation of the pathway of porphyrin synthesis in the liver of rats and mice by griseofulvin, 3,5-diethoxycarbonyl-1,4-dihydrocollidine and related drugs (1975) Evidence for two basically different mechanisms, 146, pp. 285-287. , Biochem. J
  • De Matteis, Rimington, Disturbances of porphyrin metabolism caused by griseofulvin in mice (1963) Br. J. Derm., 75, pp. 91-104
  • De Matteis, Donnelly, Runge, The effect of prolonged administration of griseofulvin in mice with reference to sex differences (1966) Cancer Res., 26, pp. 721-726
  • De Matteis, Gibbs, Tephly, Inhibition of protohaem ferrolyase in experimental porphyria (1980) Isolation and partial characterization of a modified porphyrin inhibitor, 188, pp. 145-152. , Biochem. J
  • Denk, Eckerstorfer, Talcott, Schenkman, Alteration of hepatic microsomal enzymes by griseofulvin treatment of mice (1977) Biochem. Pharmac., 26, pp. 1125-1130
  • Denk, Kalt, Abdelfattah-Gad, Meyer, Effect of griseofulvin on 5-aminolevulinate synthase and on ferrochelatase in mouse liver neoplastic nodules (1981) Cancer Res., 41, pp. 1535-1538
  • Fell, Robison, The growth, development and phosphatase activity of embryonic avian femora and limb-buds cultivated in vitro. (1929) Biochem J, 23, pp. 767-784
  • Gschnait, Konrad, Honigsmann, Denk, Wolff, Mouse model for protoporphyria. I. The liver and hepatic protoporphyrin crystals (1975) J. Invest. Derm., 65, pp. 290-299
  • Lin, Chang, Casmer, Symchowicz, Effects of phenobarbital, 3-methyl-cholanthrene and griseofulvin on the O-demethylation of griseofulvin by liver microsomes of rats and mice (1973) Drug Metab. Dispos, 1, pp. 611-618
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin-phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Marver, Tschudy, Perlroth, Collins, δ-Aminolevulinic acid synthetase. I. Studies in liver homogenates (1966) J. biol. Chem., 241, pp. 2803-2809
  • Matilla, Molland, A light and electron microscopic study of the liver in case of erythrohepatic protoporphyria and in griseofulvin-induced porphyria in mice (1974) J. clin. Path., 27, pp. 698-709
  • McIntosh, Topham, A comparison of mouse and rat liver enzymes and their response to treatment with various compounds (1972) Biochem. Pharmac., 21, pp. 1025-1029
  • Polo, Frisardi, Resnik, Schoua, Batlle, Factors influencing fluorescence spectra of free porphyrins (1988) Clin. Chem., 34, pp. 757-760
  • Sandberg, Romslo, Phototoxicity of protoporphyrin as related to its subcellular localization in mice livers after short-term feeding with griseofulvin (1981) Biochem. J., 198, pp. 67-74
  • Shaprio, Wessely, Klovins, Hepatocyte mitochondrial alterations in griseofulvin fed mice (1980) Ann. clin. Lab. Sci., 10, pp. 45-51
  • Symchowicz, Wong, Metabolism of griseofulvin-14C; studies in vitro (1966) Biochem. Pharmac., 15, pp. 1601-1606
  • Tephly, Coffman, Ingall, Abou Zeit-Har, Tabba, Smith, Identification of N-methyl-protoporphyrin IX in livers of untreated mice and mice treated with 3,5-diethoxycarbonyl-1,4-dihydrocollidine: source of the methyl group (1981) Archs Biochem. Biophys, 212, pp. 120-126
  • Vázquez, Navone, Polo, Afonso, Buzaleh, Batlle, Biosíntesis de porfirinas en cultivos de explantes tisulares (1987) Condiciones óptimas, 68, pp. 121-129. , Rev. Arg. Derm
  • Vázquez, Afonso, Buzaleh, Navone, Polo, Schoua, Batlle, The effect of griseofulvin on the heme pathway (1987) Studies on tissue explant cultures, 46, pp. 73-82. , Toxicology
  • Vázquez, Buzaleh, Navone, Polo, Schoua, Afonso, Batlle, Cultivo de explantes tisulares. II. Grado de lisis y su protección por el ácido δ-aminolevúlico (1986) An. Med. interna, 111, pp. 258-262
  • Wada, Yano, Urata, Nakao, Behavior of hepatic microsomal cytochromes after treatment of mice with drugs known to disturb porphyrin metabolism in liver (1968) Biochemical Pharmacology, 17, pp. 595-603
  • Weston-Hurst, Paget, PROTOPORPHYRIN, CIRRHOSIS AND HEPATOMATA IN THE LIVERS OF MICE GIVEN GRISEOFULVIN. (1963) British Journal of Dermatology, 75, pp. 105-112
  • Williams, Simonet, Effects of griseofulvin on enzymes associated with phase I and II of drug metabolism (1986) Biochem. Pharmac., 35, pp. 2630-2632

Citas:

---------- APA ----------
Navone, N.M., Buzaleh, A.M., Polo, C.F., Afonso, S.G., Vázquez, E.S. & del C. Batlle, A.M. (1991) . The effect of griseofulvin on the heme pathway-II. An exhaustive analysis during short and long-term challenge. General Pharmacology, 22(6), 1179-1183.
http://dx.doi.org/10.1016/0306-3623(91)90598-Z
---------- CHICAGO ----------
Navone, N.M., Buzaleh, A.M., Polo, C.F., Afonso, S.G., Vázquez, E.S., del C. Batlle, A.M. "The effect of griseofulvin on the heme pathway-II. An exhaustive analysis during short and long-term challenge" . General Pharmacology 22, no. 6 (1991) : 1179-1183.
http://dx.doi.org/10.1016/0306-3623(91)90598-Z
---------- MLA ----------
Navone, N.M., Buzaleh, A.M., Polo, C.F., Afonso, S.G., Vázquez, E.S., del C. Batlle, A.M. "The effect of griseofulvin on the heme pathway-II. An exhaustive analysis during short and long-term challenge" . General Pharmacology, vol. 22, no. 6, 1991, pp. 1179-1183.
http://dx.doi.org/10.1016/0306-3623(91)90598-Z
---------- VANCOUVER ----------
Navone, N.M., Buzaleh, A.M., Polo, C.F., Afonso, S.G., Vázquez, E.S., del C. Batlle, A.M. The effect of griseofulvin on the heme pathway-II. An exhaustive analysis during short and long-term challenge. Gen. Pharmacol. Vasc. Syst. 1991;22(6):1179-1183.
http://dx.doi.org/10.1016/0306-3623(91)90598-Z