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Garcia, A.M.; Goldemberg, A.L.; Fernández, H.; Fortunato, M.; Ricci, L.; Trucco, R.E. "Effect of chronic administration of verapamil in Duchenne muscular dystrophy" (1990) General Pharmacology. 21(6):939-942
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Abstract:

1. 1. In DMD patients the effect of chronic treatment with verapamil was investigated in the p-nitrophenylphosphatase from erythrocytes, the CK and LDH in serum and the functional activity of the muscle. 2. 2. A different behaviour in the p-nitrophenylphosphatase from untreated compared to treated DMD patients and controls is supported by the following findings: (a) values of "n" altered in F- inhibition of the enzyme with Hill coefficients -1.43, -2.18 and -2.19; (b) Arrhenius plots between 16 and 40°C with inflection points for the enzyme from treated DMD patients and controls and not from untreated DMD patients. 3. 3. Although CK and LDH in serum and the muscular evaluation showed no statistical difference between both groups, evidence is presented that in treated DMD patients the interaction membrane-enzyme is different from untreated DMD patients. © 1990.

Registro:

Documento: Artículo
Título:Effect of chronic administration of verapamil in Duchenne muscular dystrophy
Autor:Garcia, A.M.; Goldemberg, A.L.; Fernández, H.; Fortunato, M.; Ricci, L.; Trucco, R.E.
Filiación:Facultad de Ciencias Exactas y Naturales, U.N. de Mar del Plata, Funes 3250, 7600 Mar del Plata, Argentina
Departamento de Enfermedades Neuromusculares, Hospital de Niños Ricardo Gutiérrez, Gallo, 1330 Buenos Aires, Argentina
Palabras clave:4 nitrophenylphosphatase; erythrocyte enzyme; verapamil; article; child; clinical article; controlled study; creatine kinase blood level; duchenne muscular dystrophy; human; lactate dehydrogenase blood level; male; oral drug administration; priority journal; 4-Nitrophenylphosphatase; Adolescent; Alkaline Phosphatase; Child; Child, Preschool; Comparative Study; Creatine Kinase; Erythrocytes; Human; Lactate Dehydrogenase; Male; Muscles; Muscular Dystrophies; Support, Non-U.S. Gov't; Time Factors; Verapamil
Año:1990
Volumen:21
Número:6
Página de inicio:939
Página de fin:942
DOI: http://dx.doi.org/10.1016/0306-3623(90)90459-Y
Título revista:General Pharmacology
Título revista abreviado:Gen. Pharmacol. Vasc. Syst.
ISSN:03063623
CODEN:GEPHD
CAS:4 nitrophenylphosphatase, 9073-68-1; verapamil, 152-11-4, 52-53-9; 4-Nitrophenylphosphatase, EC 3.1.3.41; Alkaline Phosphatase, EC 3.1.3.1; Creatine Kinase, EC 2.7.3.2; Lactate Dehydrogenase, EC 1.1.1.27; Verapamil, 52-53-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n6_p939_Garcia

Referencias:

  • Bertorini, Bhatlacharya, Palmieri, Chesney, Pifer, Baker, Muscle calcium and magnesium content in Duchenne muscular dystrophy (1982) Neurology, 32, pp. 1088-1092
  • Bertorini, Palmieri, Griffin, Igarashi, McGee, Brown, Nutting, Karas, Effect of chronic treatment with the calcium antagonist diltiazem in Duchenne muscular dystrophy (1988) Neurology, 38, pp. 609-613
  • Dodge, Mitchell, Hahanhan, The preparation and chemical characteristic of hemoglobinfree ghosts of human erythrocytes (1963) Arch. Biochem. Biophys., 100, pp. 119-130
  • Florence, Fox, Planer, Mrooke, Activity, creatine kinase and myoglobin in Duchenne muscular dystrophy: a clue to etiology? (1985) Neurology, 35, pp. 758-761
  • Goldemberg, Farias, Trucco, Allosteric changes of p-nitrophenylphosphatase from rat erythrocytes in fat deficiency (1972) J. Biol. Chem., 247, pp. 4299-4304
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  • Webster, Silberstein, Hays, Plau, Fast muscle fibers are preferentially affected in DMD (1988) Cell, 52, pp. 503-513
  • Yoshida, Ando, Stoyoshi, Abnormalities of erythrocytes in Duchenne muscular dystrophy (1983) Ann. Neurol., 13, pp. 649-653
  • Zamudio, (1957) Medicina Fisica y Rehabilitación, p. 284. , F. Mendez, Librería de Medicina, México D.F

Citas:

---------- APA ----------
Garcia, A.M., Goldemberg, A.L., Fernández, H., Fortunato, M., Ricci, L. & Trucco, R.E. (1990) . Effect of chronic administration of verapamil in Duchenne muscular dystrophy. General Pharmacology, 21(6), 939-942.
http://dx.doi.org/10.1016/0306-3623(90)90459-Y
---------- CHICAGO ----------
Garcia, A.M., Goldemberg, A.L., Fernández, H., Fortunato, M., Ricci, L., Trucco, R.E. "Effect of chronic administration of verapamil in Duchenne muscular dystrophy" . General Pharmacology 21, no. 6 (1990) : 939-942.
http://dx.doi.org/10.1016/0306-3623(90)90459-Y
---------- MLA ----------
Garcia, A.M., Goldemberg, A.L., Fernández, H., Fortunato, M., Ricci, L., Trucco, R.E. "Effect of chronic administration of verapamil in Duchenne muscular dystrophy" . General Pharmacology, vol. 21, no. 6, 1990, pp. 939-942.
http://dx.doi.org/10.1016/0306-3623(90)90459-Y
---------- VANCOUVER ----------
Garcia, A.M., Goldemberg, A.L., Fernández, H., Fortunato, M., Ricci, L., Trucco, R.E. Effect of chronic administration of verapamil in Duchenne muscular dystrophy. Gen. Pharmacol. Vasc. Syst. 1990;21(6):939-942.
http://dx.doi.org/10.1016/0306-3623(90)90459-Y