1. Several sub-lethal doses of cyanide were assayed with the aim of obtaining significant differences in the parameters studied. A dose of 4 mg/kg s.c was selected. 2. Present studies were carried out to determine the time dependence of the effects produced by s.c. administration of a single dose of potassium cyanide as well as the recovery time of some of the toxicity indicative parameters. 3. It was found that cyanid effects continued for at least 3 days; after the parameters had recovered normal values.
| Documento: | Artículo |
| Título: | An experimental assessment of cyanide challenge dose-response, time-course and recovery of indicative toxicity parameters |
| Autor: | Buzaleh, A.M.; Vasquez, E.S.; Del Carmen Batlle, A.M. |
| Filiación: | Centro de Investigaciones sobre Porfirinas y Porfirias, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Buenos Aires, Argentina |
| Idioma: | Inglés |
| Palabras clave: | potassium cyanide; animal cell; animal experiment; article; dose response; dose time effect relation; nonhuman; priority journal; toxicity; Animal; Brain; Cytochrome-c Oxidase; Dose-Response Relationship, Drug; Injections, Subcutaneous; Liver; Mice; Myocardium; Potassium Cyanide; Support, Non-U.S. Gov't; Thiosulfate Sulfurtransferase; Time Factors |
| Año: | 1990 |
| Volumen: | 21 |
| Número: | 6 |
| Página de inicio: | 839 |
| Página de fin: | 843 |
| Título revista: | General Pharmacology |
| Título revista abreviado: | GEN. PHARMACOL. |
| ISSN: | 03063623 |
| CODEN: | GEPHD |
| CAS: | potassium cyanide, 151-50-8; Cytochrome-c Oxidase, EC 1.9.3.1; Potassium Cyanide, 151-50-8; Thiosulfate Sulfurtransferase, EC 2.8.1.1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n6_p839_Buzaleh |
