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Abstract:

1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart explant from animals treated with AIA and veronal. 3. Vincristin, GRIS and colchicine reversed AIA induction in liver explants, however reversal was partial or nil in skin and heart explants depending on the antimitotic and the tissue. 4. The usefulness of the combination of the in vivo experimental model and the in vitro explant tissue culture model, for this kind of studies is emphasized. © 1990.

Registro:

Documento: Artículo
Título:In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway
Autor:Afonso, S.G.; Polo, C.F.; Navone, N.M.; Vazquez, E.S.; Buzaleh, A.M.; Schoua, E.; Alcira Maria, d.C.B.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET, FCE y N, UBA) Ciudad Universitaria, Pabellón 11, 1428 Buenos Aires, Argentina
Palabras clave:allylisopropylacetamide; barbital; colchicine; griseofulvin; lactate dehydrogenase; porphyrin; vincristine; animal cell; animal experiment; article; heart; heme synthesis; intraperitoneal drug administration; liver; male; mouse; nonhuman; porphyria; priority journal; skin; tissue culture; 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animal; Colchicine; Enzyme Induction; Griseofulvin; Heme; In Vitro; Lactate Dehydrogenase; Male; Mice; Porphyrins; Support, Non-U.S. Gov't; Vincristine
Año:1990
Volumen:21
Número:4
Página de inicio:423
Página de fin:426
DOI: http://dx.doi.org/10.1016/0306-3623(90)90692-F
Título revista:General Pharmacology
Título revista abreviado:Gen. Pharmacol. Vasc. Syst.
ISSN:03063623
CODEN:GEPHD
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Allylisopropylacetamide, 299-78-5; Colchicine, 64-86-8; Griseofulvin, 126-07-8; Heme, 14875-96-8; Lactate Dehydrogenase, EC 1.1.1.27; Porphyrins; Vincristine, 57-22-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n4_p423_Afonso

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Citas:

---------- APA ----------
Afonso, S.G., Polo, C.F., Navone, N.M., Vazquez, E.S., Buzaleh, A.M., Schoua, E. & Alcira Maria, d.C.B. (1990) . In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway. General Pharmacology, 21(4), 423-426.
http://dx.doi.org/10.1016/0306-3623(90)90692-F
---------- CHICAGO ----------
Afonso, S.G., Polo, C.F., Navone, N.M., Vazquez, E.S., Buzaleh, A.M., Schoua, E., et al. "In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway" . General Pharmacology 21, no. 4 (1990) : 423-426.
http://dx.doi.org/10.1016/0306-3623(90)90692-F
---------- MLA ----------
Afonso, S.G., Polo, C.F., Navone, N.M., Vazquez, E.S., Buzaleh, A.M., Schoua, E., et al. "In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway" . General Pharmacology, vol. 21, no. 4, 1990, pp. 423-426.
http://dx.doi.org/10.1016/0306-3623(90)90692-F
---------- VANCOUVER ----------
Afonso, S.G., Polo, C.F., Navone, N.M., Vazquez, E.S., Buzaleh, A.M., Schoua, E., et al. In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway. Gen. Pharmacol. Vasc. Syst. 1990;21(4):423-426.
http://dx.doi.org/10.1016/0306-3623(90)90692-F