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Abstract:

1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid dehydratase (ALA-D) activity. 3. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered. © 1990.

Registro:

Documento: Artículo
Título:Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses
Autor:Buzaleh, A.M.; Vazquez, E.S.; Del Carmen Batlle, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas, Porfirias (CIPYP)-CONICET-Facultad de Ciencias Exactas y Naturales, University of Buenos Aires (UBA), Argentina
Palabras clave:cytochrome c oxidase; porphobilinogen synthase; s adenosylmethionine; thiocyanate; thiosulfate; thiosulfate sulfurtransferase; animal experiment; article; controlled study; cyanide poisoning; detoxification; intraperitoneal drug administration; mouse; nonhuman; priority journal; Animal; Cyanides; Cytochrome-c Oxidase; Lethal Dose 50; Mice; Porphobilinogen Synthase; Proteins; S-Adenosylmethionine; Sulfur Radioisotopes; Support, Non-U.S. Gov't; Thiocyanates; Thiosulfate Sulfurtransferase; Thiosulfates
Año:1990
Volumen:21
Número:1
Página de inicio:27
Página de fin:32
DOI: http://dx.doi.org/10.1016/0306-3623(90)90590-I
Título revista:General Pharmacology
Título revista abreviado:Gen. Pharmacol. Vasc. Syst.
ISSN:03063623
CODEN:GEPHD
CAS:Cyanides; Cytochrome-c Oxidase, EC 1.9.3.1; Porphobilinogen Synthase, EC 4.2.1.24; Proteins; S-Adenosylmethionine, 29908-03-0; Sulfur Radioisotopes; Thiocyanates; Thiosulfate Sulfurtransferase, EC 2.8.1.1; Thiosulfates
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n1_p27_Buzaleh

Referencias:

  • Batlle, Ferramola, Grinstein, Purification and general properties of δ-aminolevulate dehydratase from cow liver (1977) Biochem. J., 104, pp. 244-249
  • Buzaleh, Vázquez, Batlle, (1990) In vitro effect of cyanide, thiosulphate and S-adenosyl-l-methionine on the activity of rhodanese and other enzymes, , In preparation
  • Guilbault, Kramer, Specific Detection and Determination of Cyanide Using Various Quinone Derivatives. (1965) Analytical Chemistry, 37, pp. 1395-1399
  • Himwich, Saunders, Enzymatic conversion of cyanide to thiocyanate. (1948) Am J Physiol, 153, pp. 348-354
  • Isom, Way, Lethality of cyanide in the absence of inhibition of liver cytochrome oxidase (1976) Biochemical Pharmacology, 25, pp. 605-608
  • Koh, The Determination of Micro Amounts of Polythionates. I. A Photometric Method for the Determination of Pentathionate by Means of Its Cyanolysis (1965) Bulletin of the Chemical Society of Japan, 38, pp. 1510-1515
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent. (1951) J Biol Chem, 193, pp. 265-275
  • Pettersen, Cohen, Antagonism of cyanide poisoning by chlorpromazine and sodium thiosulfate*1 (1985) Toxicology and Applied Pharmacology, 81, pp. 265-273
  • Rutkowski, Roebuck, Smith, Effects of protein-free diet and food deprivation on hepatic rhodanese activity, serum proteins and acute cyanide lethality in mice. (1985) J Nutr, 115, pp. 132-137
  • Schubert, Brill, Antagonism of experimental cyanide toxicity in relation to the in vitro activity of cytochrome oxidase (1978) J. Pharmac. Exp. Ther., 162, pp. 352-359
  • Solomonson, Cyanide as metabolic inhibitor (1982) Cyanide in Biology, pp. 11-28. , Academic Press, London
  • Sörbo, Crystalline Rhodanese. I. Purification and Physicochemical Examination. (1953) Acta Chemica Scandinavica, 7, pp. 1129-1136
  • Sylvester, Saunders, Hayton, Way, Alteration on the pharmacokinetics of sodium cyanide by sodium thiosulphate (1981) Proc. West. Pharmac. Soc., 24, pp. 135-136
  • Westley, Rhodanese and the sulfane pool (1980) Enzymatic Basis of Detoxication, 2, pp. 245-263. , Academic Press, London, chapter 13
  • Westley, Rhodanese (1981) Methods in Enzymology, 77, pp. 285-291. , Academic Press, New York
  • Yonetani, Ray, STUDIES ON CYTOCHROME OXIDASE. VI. KINETICS OF THE AEROBIC OXIDATION OF FERROCYTOCHROME C BY CYTOCHROME OXIDASE. (1965) J Biol Chem, 240, pp. 3392-3398

Citas:

---------- APA ----------
Buzaleh, A.M., Vazquez, E.S. & Del Carmen Batlle, A.M. (1990) . Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses. General Pharmacology, 21(1), 27-32.
http://dx.doi.org/10.1016/0306-3623(90)90590-I
---------- CHICAGO ----------
Buzaleh, A.M., Vazquez, E.S., Del Carmen Batlle, A.M. "Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses" . General Pharmacology 21, no. 1 (1990) : 27-32.
http://dx.doi.org/10.1016/0306-3623(90)90590-I
---------- MLA ----------
Buzaleh, A.M., Vazquez, E.S., Del Carmen Batlle, A.M. "Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses" . General Pharmacology, vol. 21, no. 1, 1990, pp. 27-32.
http://dx.doi.org/10.1016/0306-3623(90)90590-I
---------- VANCOUVER ----------
Buzaleh, A.M., Vazquez, E.S., Del Carmen Batlle, A.M. Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses. Gen. Pharmacol. Vasc. Syst. 1990;21(1):27-32.
http://dx.doi.org/10.1016/0306-3623(90)90590-I