Abstract:
1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid dehydratase (ALA-D) activity. 3. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered. © 1990.
Registro:
Documento: |
Artículo
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Título: | Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses |
Autor: | Buzaleh, A.M.; Vazquez, E.S.; Del Carmen Batlle, A.M. |
Filiación: | Centro de Investigaciones sobre Porfirinas, Porfirias (CIPYP)-CONICET-Facultad de Ciencias Exactas y Naturales, University of Buenos Aires (UBA), Argentina
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Palabras clave: | cytochrome c oxidase; porphobilinogen synthase; s adenosylmethionine; thiocyanate; thiosulfate; thiosulfate sulfurtransferase; animal experiment; article; controlled study; cyanide poisoning; detoxification; intraperitoneal drug administration; mouse; nonhuman; priority journal; Animal; Cyanides; Cytochrome-c Oxidase; Lethal Dose 50; Mice; Porphobilinogen Synthase; Proteins; S-Adenosylmethionine; Sulfur Radioisotopes; Support, Non-U.S. Gov't; Thiocyanates; Thiosulfate Sulfurtransferase; Thiosulfates |
Año: | 1990
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Volumen: | 21
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Número: | 1
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Página de inicio: | 27
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Página de fin: | 32
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DOI: |
http://dx.doi.org/10.1016/0306-3623(90)90590-I |
Título revista: | General Pharmacology
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Título revista abreviado: | Gen. Pharmacol. Vasc. Syst.
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ISSN: | 03063623
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CODEN: | GEPHD
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CAS: | Cyanides; Cytochrome-c Oxidase, EC 1.9.3.1; Porphobilinogen Synthase, EC 4.2.1.24; Proteins; S-Adenosylmethionine, 29908-03-0; Sulfur Radioisotopes; Thiocyanates; Thiosulfate Sulfurtransferase, EC 2.8.1.1; Thiosulfates
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n1_p27_Buzaleh |
Referencias:
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- Buzaleh, Vázquez, Batlle, (1990) In vitro effect of cyanide, thiosulphate and S-adenosyl-l-methionine on the activity of rhodanese and other enzymes, , In preparation
- Guilbault, Kramer, Specific Detection and Determination of Cyanide Using Various Quinone Derivatives. (1965) Analytical Chemistry, 37, pp. 1395-1399
- Himwich, Saunders, Enzymatic conversion of cyanide to thiocyanate. (1948) Am J Physiol, 153, pp. 348-354
- Isom, Way, Lethality of cyanide in the absence of inhibition of liver cytochrome oxidase (1976) Biochemical Pharmacology, 25, pp. 605-608
- Koh, The Determination of Micro Amounts of Polythionates. I. A Photometric Method for the Determination of Pentathionate by Means of Its Cyanolysis (1965) Bulletin of the Chemical Society of Japan, 38, pp. 1510-1515
- Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent. (1951) J Biol Chem, 193, pp. 265-275
- Pettersen, Cohen, Antagonism of cyanide poisoning by chlorpromazine and sodium thiosulfate*1 (1985) Toxicology and Applied Pharmacology, 81, pp. 265-273
- Rutkowski, Roebuck, Smith, Effects of protein-free diet and food deprivation on hepatic rhodanese activity, serum proteins and acute cyanide lethality in mice. (1985) J Nutr, 115, pp. 132-137
- Schubert, Brill, Antagonism of experimental cyanide toxicity in relation to the in vitro activity of cytochrome oxidase (1978) J. Pharmac. Exp. Ther., 162, pp. 352-359
- Solomonson, Cyanide as metabolic inhibitor (1982) Cyanide in Biology, pp. 11-28. , Academic Press, London
- Sörbo, Crystalline Rhodanese. I. Purification and Physicochemical Examination. (1953) Acta Chemica Scandinavica, 7, pp. 1129-1136
- Sylvester, Saunders, Hayton, Way, Alteration on the pharmacokinetics of sodium cyanide by sodium thiosulphate (1981) Proc. West. Pharmac. Soc., 24, pp. 135-136
- Westley, Rhodanese and the sulfane pool (1980) Enzymatic Basis of Detoxication, 2, pp. 245-263. , Academic Press, London, chapter 13
- Westley, Rhodanese (1981) Methods in Enzymology, 77, pp. 285-291. , Academic Press, New York
- Yonetani, Ray, STUDIES ON CYTOCHROME OXIDASE. VI. KINETICS OF THE AEROBIC OXIDATION OF FERROCYTOCHROME C BY CYTOCHROME OXIDASE. (1965) J Biol Chem, 240, pp. 3392-3398
Citas:
---------- APA ----------
Buzaleh, A.M., Vazquez, E.S. & Del Carmen Batlle, A.M.
(1990)
. Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses. General Pharmacology, 21(1), 27-32.
http://dx.doi.org/10.1016/0306-3623(90)90590-I---------- CHICAGO ----------
Buzaleh, A.M., Vazquez, E.S., Del Carmen Batlle, A.M.
"Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses"
. General Pharmacology 21, no. 1
(1990) : 27-32.
http://dx.doi.org/10.1016/0306-3623(90)90590-I---------- MLA ----------
Buzaleh, A.M., Vazquez, E.S., Del Carmen Batlle, A.M.
"Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses"
. General Pharmacology, vol. 21, no. 1, 1990, pp. 27-32.
http://dx.doi.org/10.1016/0306-3623(90)90590-I---------- VANCOUVER ----------
Buzaleh, A.M., Vazquez, E.S., Del Carmen Batlle, A.M. Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses. Gen. Pharmacol. Vasc. Syst. 1990;21(1):27-32.
http://dx.doi.org/10.1016/0306-3623(90)90590-I