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Abstract:

The effects of oral chronic cyanide administration to mice were studied. Cyanide intoxication was confirmed by the increased levels of this poison and the concomitant inhibition of cytochrome oxidase activity in liver, brain, heart and blood. The detoxifying enzyme rhodanese was measured. The state of the sulfane sulfur pool was investigated by determination of the cyanide labile-sulfur levels. A clear correlation between rhodanese activity and sulfur content was obtained as a consequence of cyanide action. These results support the belief that rhodanese plays a fundamental role in the detoxification process of cyanide, in preventing cyanide reaching the target tissues. © 1989.

Registro:

Documento: Artículo
Título:Cyanide intoxication-I. An oral chronic animal model
Autor:Buzaleh, A.M.; Vazquez, E.S.; Del Battle, C.A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET, Facultad de Ciencias Exactas y Naturales, 1448 Buenos Aires, Argentina
Palabras clave:cyanide; cytochrome c oxidase; thiocyanate; thiosulfate sulfurtransferase; animal cell; animal experiment; animal model; blood; brain; detoxification; heart; intoxication; liver; mouse; nonhuman; priority journal; Administration, Oral; Animal; Cyanides; Cytochrome-c Oxidase; Mice; Proteins; Sulfur; Support, Non-U.S. Gov't; Thiocyanates; Thiosulfate Sulfurtransferase; Time Factors
Año:1989
Volumen:20
Número:3
Página de inicio:323
Página de fin:327
DOI: http://dx.doi.org/10.1016/0306-3623(89)90267-X
Título revista:General Pharmacology
Título revista abreviado:Gen. Pharmacol. Vasc. Syst.
ISSN:03063623
CODEN:GEPHD
CAS:cyanide, 57-12-5; cytochrome c oxidase, 72841-18-0, 9001-16-5; thiocyanate, 302-04-5; thiosulfate sulfurtransferase, 9026-04-4; Cyanides; Cytochrome-c Oxidase, EC 1.9.3.1; Proteins; Sulfur, 7704-34-9; Thiocyanates; Thiosulfate Sulfurtransferase, EC 2.8.1.1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v20_n3_p323_Buzaleh

Referencias:

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Citas:

---------- APA ----------
Buzaleh, A.M., Vazquez, E.S. & Del Battle, C.A.M. (1989) . Cyanide intoxication-I. An oral chronic animal model. General Pharmacology, 20(3), 323-327.
http://dx.doi.org/10.1016/0306-3623(89)90267-X
---------- CHICAGO ----------
Buzaleh, A.M., Vazquez, E.S., Del Battle, C.A.M. "Cyanide intoxication-I. An oral chronic animal model" . General Pharmacology 20, no. 3 (1989) : 323-327.
http://dx.doi.org/10.1016/0306-3623(89)90267-X
---------- MLA ----------
Buzaleh, A.M., Vazquez, E.S., Del Battle, C.A.M. "Cyanide intoxication-I. An oral chronic animal model" . General Pharmacology, vol. 20, no. 3, 1989, pp. 323-327.
http://dx.doi.org/10.1016/0306-3623(89)90267-X
---------- VANCOUVER ----------
Buzaleh, A.M., Vazquez, E.S., Del Battle, C.A.M. Cyanide intoxication-I. An oral chronic animal model. Gen. Pharmacol. Vasc. Syst. 1989;20(3):323-327.
http://dx.doi.org/10.1016/0306-3623(89)90267-X