Artículo

Guy, N.C.; Garcia, Y.A.; Sivils, J.C.; Galigniana, M.D.; Cox, M.B. "Functions of the Hsp90-binding FKBP immunophilins" (2015) Sub-Cellular Biochemistry. 78:1-34
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Abstract:

Hsp90 functionally interacts with a broad array of client proteins, but in every case examined Hsp90 is accompanied by one or more co-chaperones. One class of co-chaperone contains a tetratricopeptide repeat domain that targets the co-chaperone to the C-terminal region of Hsp90. Within this class are Hsp90-binding peptidylprolyl isomerases, most of which belong to the FK506-binding protein (FKBP) family. Despite the common association of FKBP co-chaperones with Hsp90, it is now clear that the client protein influences, and is influenced by, the particular FKBP bound to Hsp90. Examples include Xap2 in aryl hydrocarbon receptor complexes and FKBP52 in steroid receptor complexes. In this chapter, we discuss the known functional roles played by FKBP co-chaperones and, where possible, relate distinctive functions to structural differences between FKBP members. © Springer International Publishing Switzerland 2015

Registro:

Documento: Artículo
Título:Functions of the Hsp90-binding FKBP immunophilins
Autor:Guy, N.C.; Garcia, Y.A.; Sivils, J.C.; Galigniana, M.D.; Cox, M.B.
Filiación:Department of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, United States
Departamento de Química Biológica/IQUIBICEN, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:FKBP; Hsp90; Immunophilin; Steroid hormone receptor
Año:2015
Volumen:78
Página de inicio:1
Página de fin:34
DOI: http://dx.doi.org/10.1007/978-3-319-11731-7_2
Título revista:Sub-Cellular Biochemistry
Título revista abreviado:Sub-Cell. Biochem.
ISSN:03060225
CODEN:SBCBA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03060225_v78_n_p1_Guy

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Citas:

---------- APA ----------
Guy, N.C., Garcia, Y.A., Sivils, J.C., Galigniana, M.D. & Cox, M.B. (2015) . Functions of the Hsp90-binding FKBP immunophilins. Sub-Cellular Biochemistry, 78, 1-34.
http://dx.doi.org/10.1007/978-3-319-11731-7_2
---------- CHICAGO ----------
Guy, N.C., Garcia, Y.A., Sivils, J.C., Galigniana, M.D., Cox, M.B. "Functions of the Hsp90-binding FKBP immunophilins" . Sub-Cellular Biochemistry 78 (2015) : 1-34.
http://dx.doi.org/10.1007/978-3-319-11731-7_2
---------- MLA ----------
Guy, N.C., Garcia, Y.A., Sivils, J.C., Galigniana, M.D., Cox, M.B. "Functions of the Hsp90-binding FKBP immunophilins" . Sub-Cellular Biochemistry, vol. 78, 2015, pp. 1-34.
http://dx.doi.org/10.1007/978-3-319-11731-7_2
---------- VANCOUVER ----------
Guy, N.C., Garcia, Y.A., Sivils, J.C., Galigniana, M.D., Cox, M.B. Functions of the Hsp90-binding FKBP immunophilins. Sub-Cell. Biochem. 2015;78:1-34.
http://dx.doi.org/10.1007/978-3-319-11731-7_2