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Abstract:

1. The effect of the fluorinated ether anaesthetics enflurane and isoflurane in mice on haem metabolism and regulation in different metabolic states, such as depression and induction of cytochrome P450 produced by allylisopropylacetamide (AIA) and imidazole, respectively, was investigated. 2. Mice previously treated with AIA (350 mg/kg, i.p.) or imidazole (400 mg/kg, i.p.) received a single dose (1 mL/kg, i.p.) of enflurane or isoflurane and were killed 20 min after anaesthetic administration. 3. Induction of δ-aminolevulinic acid synthetase (ALA-S) activity was found, as expected, in animals receiving AIA and also in animals treated with AIA plus anaesthesia, but no change in the activity of either porphobilinogenase (PBGase) or porphobilinogen deaminase (PBG-D) activities was detected in these two groups of animals. An additional increase in haem destruction was observed in the AIA plus isoflurane-treated group. When mice were injected with imidazol alone or in combination with the anaesthetics, ALA-S activity was increased 50-90% in all groups, but again no change in PBGase or PBG-D activity was observed. Haem oxygenase was diminished in mice receiving imidazole and anaesthesia. 4. In conclusion, neither enflurane nor isoflurane caused additional disturbances in haem metabolism to those produced by AIA or imidazole alone.

Registro:

Documento: Artículo
Título:Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: Studies on the haem pathway
Autor:Buzaleh, A.M.; Del Carmen Martinez, M.; Del Carmen Batlle, A.M.
Filiación:Centro de Investigaciones Sobre Porfirinas y Porfirias, Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina
Viamonte 188L 10 'A', C1056ABA, Buenos Aires, Argentina
Palabras clave:Allylisopropylacetamide; Cytochrome P450; Enflurane; Haem metabolism; Imidazole; Isoflurane; Volatile anaesthetics; 5 aminolevulinate synthase; allylisopropylacetamide; cytochrome P450; enflurane; heme; heme oxygenase; imidazole; isoflurane; porphobilinogen deaminase; thiosulfate sulfurtransferase; aerobic metabolism; animal tissue; article; controlled study; enzyme activity; enzyme induction; enzyme inhibition; heme synthesis; liver metabolism; male; nonhuman; rat; 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Ammonia-Lyases; Anesthetics, Inhalation; Animals; Cytochrome P-450 Enzyme System; Enflurane; Heme; Heme Oxygenase (Decyclizing); Hydroxymethylbilane Synthase; Imidazoles; Isoflurane; Liver; Mice; Microsomes, Liver
Año:2000
Volumen:27
Número:10
Página de inicio:796
Página de fin:800
DOI: http://dx.doi.org/10.1046/j.1440-1681.2000.03346.x
Título revista:Clinical and Experimental Pharmacology and Physiology
Título revista abreviado:Clin. Exp. Pharmacol. Physiol.
ISSN:03051870
CODEN:CEXPB
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Allylisopropylacetamide, 299-78-5; Aminolevulinic Acid, 106-60-5; Ammonia-Lyases, EC 4.3.1.-; Anesthetics, Inhalation; Cytochrome P-450 Enzyme System, 9035-51-2; Enflurane, 13838-16-9; Heme Oxygenase (Decyclizing), EC 1.14.99.3; Heme, 14875-96-8; Hydroxymethylbilane Synthase, EC 2.5.1.61; Imidazoles; Isoflurane, 26675-46-7; porphobilinogenase, EC 5.-
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03051870_v27_n10_p796_Buzaleh

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Citas:

---------- APA ----------
Buzaleh, A.M., Del Carmen Martinez, M. & Del Carmen Batlle, A.M. (2000) . Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: Studies on the haem pathway. Clinical and Experimental Pharmacology and Physiology, 27(10), 796-800.
http://dx.doi.org/10.1046/j.1440-1681.2000.03346.x
---------- CHICAGO ----------
Buzaleh, A.M., Del Carmen Martinez, M., Del Carmen Batlle, A.M. "Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: Studies on the haem pathway" . Clinical and Experimental Pharmacology and Physiology 27, no. 10 (2000) : 796-800.
http://dx.doi.org/10.1046/j.1440-1681.2000.03346.x
---------- MLA ----------
Buzaleh, A.M., Del Carmen Martinez, M., Del Carmen Batlle, A.M. "Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: Studies on the haem pathway" . Clinical and Experimental Pharmacology and Physiology, vol. 27, no. 10, 2000, pp. 796-800.
http://dx.doi.org/10.1046/j.1440-1681.2000.03346.x
---------- VANCOUVER ----------
Buzaleh, A.M., Del Carmen Martinez, M., Del Carmen Batlle, A.M. Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: Studies on the haem pathway. Clin. Exp. Pharmacol. Physiol. 2000;27(10):796-800.
http://dx.doi.org/10.1046/j.1440-1681.2000.03346.x