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Polo, C.F.; Vazquez, E.S.; Caballero, F.; Gerez, E.; Batlle, A.M.d.C. "Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation" (1992) Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 103(1):251-256
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Abstract:

1. 1. Heme regulation before the appearance of hyperplastic nodules was investigated in mice models of hepatocarcinogenesis. 2. 2. With this aim 5-aminolaevulinate synthetase (ALA-S), microsomal heme-oxygenase (MHO), mitochondrial and cytoplasmic rhodanese activities were examined throughout a period of 35 days in animals exposed to dietary p-dimethylaminoazobenzene (DAB). 3. 3. ALA-S activity was significantly diminished (50%) on day 14, then showing a sharply rising profile from day 28 onwards, and reaching 350% on day 35. 4. 4. A similar profile was observed for mitochondrial rhodanese activity. 5. 5. Changes in MHO and cytoplasmic rhodanese activities were almost the opposite to those observed for ALA-S. 6. 6. The distinctive alteration in mitochondrial and cytoplasmic rhodanese would suggest that it plays a subtle role in ALA-S regulation during carcinogenesis initiation through a mechanism that appears to involved subcellular localization controls perhaps by means of the breakage of cystine trisulphide postulated to act as an ALA-S activator. 7. 7. Taking into account the present results, we suggest a probable mechanism for the onset of hepatocarcinogenesis that includes a primary activating liver status, provoking biochemical aberration leading to the stage of initiation of hepatocarcinogenesis involving the whole organ. © 1992.

Registro:

Documento: Artículo
Título:Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation
Autor:Polo, C.F.; Vazquez, E.S.; Caballero, F.; Gerez, E.; Batlle, A.M.d.C.
Filiación:Centro de Investigaciones sobre Porfirinas y Porifirias (CIPYP), CONICET, FCEN, Ciudad Universitaria, Pabellon II, 2do Piso, 1428 Buenos Aires, Argentina
Palabras clave:4 dimethylaminoazobenzene; 5 aminolevulinate synthase; heme oxygenase; thiosulfate sulfurtransferase; animal experiment; animal model; animal tissue; article; heme synthesis; liver carcinogenesis; mouse; nonhuman; priority journal; 5-Aminolevulinate Synthetase; Animal; Cytoplasm; Heme; Heme Oxygenase (Decyclizing); Kinetics; Liver; Liver Neoplasms, Experimental; Male; Mice; Microsomes, Liver; Mitochondria, Liver; p-Dimethylaminoazobenzene; Support, Non-U.S. Gov't; Thiosulfate Sulfurtransferase; Animalia
Año:1992
Volumen:103
Número:1
Página de inicio:251
Página de fin:256
DOI: http://dx.doi.org/10.1016/0305-0491(92)90440-3
Título revista:Comparative Biochemistry and Physiology -- Part B: Biochemistry and
ISSN:03050491
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Heme Oxygenase (Decyclizing), EC 1.14.99.3; Heme, 14875-96-8; p-Dimethylaminoazobenzene, 60-11-7; Thiosulfate Sulfurtransferase, EC 2.8.1.1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v103_n1_p251_Polo

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Citas:

---------- APA ----------
Polo, C.F., Vazquez, E.S., Caballero, F., Gerez, E. & Batlle, A.M.d.C. (1992) . Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation. Comparative Biochemistry and Physiology -- Part B: Biochemistry and, 103(1), 251-256.
http://dx.doi.org/10.1016/0305-0491(92)90440-3
---------- CHICAGO ----------
Polo, C.F., Vazquez, E.S., Caballero, F., Gerez, E., Batlle, A.M.d.C. "Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation" . Comparative Biochemistry and Physiology -- Part B: Biochemistry and 103, no. 1 (1992) : 251-256.
http://dx.doi.org/10.1016/0305-0491(92)90440-3
---------- MLA ----------
Polo, C.F., Vazquez, E.S., Caballero, F., Gerez, E., Batlle, A.M.d.C. "Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation" . Comparative Biochemistry and Physiology -- Part B: Biochemistry and, vol. 103, no. 1, 1992, pp. 251-256.
http://dx.doi.org/10.1016/0305-0491(92)90440-3
---------- VANCOUVER ----------
Polo, C.F., Vazquez, E.S., Caballero, F., Gerez, E., Batlle, A.M.d.C. Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation. 1992;103(1):251-256.
http://dx.doi.org/10.1016/0305-0491(92)90440-3