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Abstract:

1. 1. Using different doses of free and liposome encapsulated aminolevulinic acid (ALA) (between 2 and 8 mg/animal), given i.p., s.c. and intra-tumoural (i.t.), in vivo porphyrin synthesis by tumour, red blood cells (RBC) and different organs from tumour-bearing mice (TBM) and normal mice (NM) at different times, up to 24 hr after ALA administration, was examined. 2. 2. It was found that by giving entrapped ALA, at a dose of 6 mg/animal (or 200 mg/kg wt), after 10 hr, a high level of porphyrin accumulation in the tumour was produced (7 μg/g tissue). Low synthesis occurred in muscle, lung, brain, RBC and skin; in spleen, kidney and liver synthesis is significant after 10 hr, but after 24 hr returned to normal values in the spleen and to about 2-3 μg/g tissue in the kidney and liver. 3. 3. The tumour/skin porphyrin concentration ratio after 10 hr was nearly 30, the highest so far reported. 4. 4. These results support our previous in vitro findings, indicating that free or encapsulated ALA might be used for early diagnosis of cancer and in photodynamic therapy. © 1992.

Registro:

Documento: Artículo
Título:Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid
Autor:Fukuda, H.; Paredes, S.; del C. Battle, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), FCE y N (UBA) and CONICET, Ciudad Universitaria, Pabellón II, 2do. Piso, 1428-Buenos Aires, Argentina (Fax: 54 1 41 7447)
Palabras clave:aminolevulinic acid; liposome; porphyrin; animal experiment; animal tissue; article; cancer; controlled study; encapsulation; intraperitoneal drug administration; intratumoral drug administration; mouse; nonhuman; priority journal; subcutaneous drug administration; tissue distribution; tumor; Aminolevulinic Acid; Animal; Drug Carriers; Liposomes; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Organ Specificity; Porphyrins; Support, Non-U.S. Gov't; Animalia
Año:1992
Volumen:102
Número:2
Página de inicio:433
Página de fin:436
DOI: http://dx.doi.org/10.1016/0305-0491(92)90147-J
Título revista:Comparative Biochemistry and Physiology -- Part B: Biochemistry and
ISSN:03050491
CAS:Aminolevulinic Acid, 106-60-5; Drug Carriers; Liposomes; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v102_n2_p433_Fukuda

Referencias:

  • Dougherty, (1984) Excerpts from Photodynamic Therapy Workshop, , October, Santa Barbara, Western Institute for Laser Treatment
  • Fukuda, Paredes, Battle, Tumor-localizing properties of porphyrins. In vitro studies using the porphyrin precursor, aminolevulinic acid, in free and liposo encapsulated forms (1989) Drug Design Delivery, 5, pp. 133-139
  • Gomer, Dougherty, Determination of 3H and 14C-HpD distribution in malignant and normal tissue (1979) Cancer Res., 39, pp. 146-151
  • Jori, Reddi, Cozzani, Tonio, Controlled targetting of different subcellular sites by porphyrins in tumor bearing mice (1986) Br. J. Cancer, 53, pp. 615-621
  • Moan, Porphyrin photosensitization and phototherapy (1986) Photochem. Photobiol., 43, pp. 681-690
  • Navone, Frisardi, Resnick, Batlle, Polo, Porphyrin biosynthesis in human breast cancer. Preliminary mimetic in vitro studies (1988) Med. Sci. Res., 16, pp. 61-62
  • Navone, Polo, Frisardi, Andrade, Battle, Heme biosynthesis in human breast cancer. Mimetic in vitro studies and some heme enzymic activity levels, and APPENDIX Heme enzyme pattern in mouse mammary (1990) Int. J. Biochem., 22, p. 1410
  • Peng, Evensen, Rimington, Moan, A comparison of different photosensitizing dyes with respect to uptake C3H-tumors and tissues of mice (1987) Cancer Lett., 36, pp. 1-10
  • Spikes, Phtalocyanines as photosensitizers in biological systems and for the photodynamic therapy of tumors (1986) Photochem. Photobiol., 43, pp. 691-699

Citas:

---------- APA ----------
Fukuda, H., Paredes, S. & del C. Battle, A.M. (1992) . Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid. Comparative Biochemistry and Physiology -- Part B: Biochemistry and, 102(2), 433-436.
http://dx.doi.org/10.1016/0305-0491(92)90147-J
---------- CHICAGO ----------
Fukuda, H., Paredes, S., del C. Battle, A.M. "Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid" . Comparative Biochemistry and Physiology -- Part B: Biochemistry and 102, no. 2 (1992) : 433-436.
http://dx.doi.org/10.1016/0305-0491(92)90147-J
---------- MLA ----------
Fukuda, H., Paredes, S., del C. Battle, A.M. "Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid" . Comparative Biochemistry and Physiology -- Part B: Biochemistry and, vol. 102, no. 2, 1992, pp. 433-436.
http://dx.doi.org/10.1016/0305-0491(92)90147-J
---------- VANCOUVER ----------
Fukuda, H., Paredes, S., del C. Battle, A.M. Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid. 1992;102(2):433-436.
http://dx.doi.org/10.1016/0305-0491(92)90147-J