Abstract:
Vero cell cultures persistently infected with Junin virus and subjected to different cultural conditions were established. The production of infectious plaque-forming virus, ts mutants and interfering viral particles was determined at different times during 110 days after infection. Carrier cultures maintained in stationary conditions continuously released PFU while proliferating persistent cultures exhibited a cyclical pattern which tends to a rapid PFU disappearance. Concomitantly, in stationary cultures the production of interfering particles was delayed and was lower than in actively growing persistent cells. The metabolic state of the infected cells did not affect the release of ts mutants. The results suggest that a cellular function is involved on the regulation of Junin virus persistent infections. © 1985 Springer-Verlag.
Registro:
Documento: |
Artículo
|
Título: | Influence of cellular functions on the evolution of persistent infections with Junin virus |
Autor: | Candurra, N.A.; Damonte, E.B. |
Filiación: | Cátedra de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
|
Palabras clave: | cell culture; cell function; defective virus; heredity; in vitro study; junin virus; monkey; nonhuman; persistent infection; priority journal; temperature sensitive mutant; Animal; Arenaviridae; Arenaviruses, New World; Cells, Cultured; Cercopithecus aethiops; Cycloheximide; Dactinomycin; Mice; Proteins; Support, Non-U.S. Gov't; Temperature; Viral Interference |
Año: | 1985
|
Volumen: | 86
|
Número: | 3-4
|
Página de inicio: | 275
|
Página de fin: | 282
|
DOI: |
http://dx.doi.org/10.1007/BF01309831 |
Título revista: | Archives of Virology
|
Título revista abreviado: | Arch. Virol.
|
ISSN: | 03048608
|
CODEN: | ARVID
|
CAS: | Cycloheximide, 66-81-9; Dactinomycin, 50-76-0; Proteins
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03048608_v86_n3-4_p275_Candurra |
Referencias:
- Bedows, E., Payne, F.E., Host cell factors involved in the production of slowly sedimenting nucleocapsids in measles virus-infected cells (1981) J. Virol., 37, pp. 103-108
- Coto, C.E., Leon, M.E., Help, G.I., Rol del genoma del huésped en la multiplicación del virus Junín (FHA) (1975) Acta Bqca. Clínica Latinoamericana, 9, pp. 246-257
- Coto, C.E., Leon, M.E., Peralta, L.M., Help, G.I., Laguens, R.P., Induction of infectious virus and viral surface antigen in Vero cells persistently infected with Junin virus (1979) Humoral Immunity and Neurological Diseases, pp. 405-415. , D., Karcher, A., Lowenthal, A. D., Strosberg, Plenum Press, New York
- Damonte, E.B., Coto, C.E., Temperature sensitivity of the arenavirus Junin isolated from persistently infected Vero cells (1979) Intervirology, 11, pp. 282-287
- Damonte, E.B., D'Aiutolo, A.C., Coto, C.E., Persistent infection of Vero cells with Tacaribe virus (1981) J. gen. Virol., 56, pp. 41-48
- Damonte, E.B., Mersich, S.E., Coto, C.E., Response of cells persistently infected with arenaviruses to superinfection with homotypic and heterotypic viruses (1983) Virology, 129, pp. 474-478
- Francoeur, M., Stanners, C.P., Cellular quiescence modulates the replication of L ts mutants of vesicular stomatitis virus (1980) J. gen. Virol., 50, pp. 337-344
- Jacobson, S., Dutko, F.J., Pfau, C.J., Determinants of spontaneous recovery and persistence in MDCK cells infected with lymphocytic choriomeningitis virus (1979) J. gen. Virol., 44, pp. 113-121
- Kang, C.Y., Allen, R., Host function-dependent induction of defective interfering particles of vesicular stomatitis virus (1978) J. Virol., 25, pp. 202-206
- Lee, G.T.Y., Engelhardt, D.L., Protein metabolism during growth of Vero cells (1977) J. Cell. Physiol., 92, pp. 293-302
- Lehmann-Grube, F., Martinez Peralta, L., Bruns, N., Lohler, J., Persistent infection of mice with the lymphocytic choriomeningitis virus (1983) Compr. Virol., 18, pp. 43-103
- Mersich, S.E., Damonte, E.B., Coto, C.E., Induction of RNA polymerase II activity in Junin virus infected cells (1981) Intervirology, 16, pp. 123-127
- Ogura, H., Sato, H., Hatano, M., Relation of HVJ (Sendai virus) production to cell growth phase in persistently infected mouse 3T3 cells (1984) Arch. Virol., 80, pp. 47-57
- Rawls, W.E., Chan, M.A., Gee, S.R., Mechanisms of persistence in arenavirus infections: a brief review (1981) Canad. J. Microbiol., 27, pp. 568-574
- Welsh, R.M., Buchmeier, M.J., Protein analysis of defective interfering lymphocytic choriomeningitis virus and persistently infected cells (1979) Virology, 96, pp. 503-515
Citas:
---------- APA ----------
Candurra, N.A. & Damonte, E.B.
(1985)
. Influence of cellular functions on the evolution of persistent infections with Junin virus. Archives of Virology, 86(3-4), 275-282.
http://dx.doi.org/10.1007/BF01309831---------- CHICAGO ----------
Candurra, N.A., Damonte, E.B.
"Influence of cellular functions on the evolution of persistent infections with Junin virus"
. Archives of Virology 86, no. 3-4
(1985) : 275-282.
http://dx.doi.org/10.1007/BF01309831---------- MLA ----------
Candurra, N.A., Damonte, E.B.
"Influence of cellular functions on the evolution of persistent infections with Junin virus"
. Archives of Virology, vol. 86, no. 3-4, 1985, pp. 275-282.
http://dx.doi.org/10.1007/BF01309831---------- VANCOUVER ----------
Candurra, N.A., Damonte, E.B. Influence of cellular functions on the evolution of persistent infections with Junin virus. Arch. Virol. 1985;86(3-4):275-282.
http://dx.doi.org/10.1007/BF01309831