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Abstract:

The effects of enflurane and isoflurane on heme metabolism, its regulation, and on some parameters involved in the hepatic drug metabolising system in animals under GSH depletion were investigated. A single dose of the anaesthethics (1 ml kg-1, i.p.) was administered to control and GSH depleted mice, animals were sacrificed 20 min after. As a consequence of GSH depletion, a significant inhibition in δ-Aminolevulinic acid synthetase activity, the first enzyme of heme bioxynthesis, and a striking induction in Heme oxygenase activity, the main enzyme of heme metabolism, were observed. Cytochrome P-450 levels and the activities of P-4502E1 and glutathione S-transferase were increased. These changes in heme metabolism and drug metabolising enzyme system were not altered further by the administration of enflurane or isoflurane. These findings would indicate that the status of oxidative stress produced by GSH depletion could not be affected by these anaesthetics and/or that disturbances in heme metabolism were already too important to undergo further variations. © 2005 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Glutathione depletion and anaesthesia in mice alter heme and drug metabolising enzymes
Autor:Buzaleh, A.M.; Batlle, A.M.D.C.
Filiación:Centro de Investigaciones Sobre Porfirinas Y Porfirias (CIPYP)- (CONICET- FCEN, UBA), Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina
Viamonte 1881 10 A, C1056ABA- Buenos Aires, Argentina
Palabras clave:Drug metabolising enzyme system; Enflurane; GSH; Heme metabolism; Isoflurane; 5 aminolevulinate synthase; drug metabolizing enzyme; enflurane; glutathione; heme; isoflurane; anesthesia; animal experiment; animal model; animal tissue; article; controlled study; drug metabolism; heme synthesis; liver metabolism; male; metabolic disorder; mouse; nonhuman; priority journal; regulatory mechanism; 5-Aminolevulinate Synthetase; Acetaminophen; Anesthesia, Inhalation; Animals; Enflurane; Glutathione; Glutathione Transferase; Heme; Isoflurane; Male; Mice; Pharmaceutical Preparations; Animalia
Año:2005
Volumen:1723
Número:1-3
Página de inicio:128
Página de fin:134
DOI: http://dx.doi.org/10.1016/j.bbagen.2005.01.007
Título revista:Biochimica et Biophysica Acta - General Subjects
Título revista abreviado:Biochim. Biophys. Acta Gen. Subj.
ISSN:03044165
CODEN:BBGSB
CAS:5 aminolevulinate synthase, 9037-14-3; enflurane, 13838-16-9; glutathione, 70-18-8; heme, 14875-96-8; isoflurane, 26675-46-7; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Acetaminophen, 103-90-2; Enflurane, 13838-16-9; Glutathione Transferase, EC 2.5.1.18; Glutathione, 70-18-8; Heme, 14875-96-8; Isoflurane, 26675-46-7; Pharmaceutical Preparations
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03044165_v1723_n1-3_p128_Buzaleh

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Citas:

---------- APA ----------
Buzaleh, A.M. & Batlle, A.M.D.C. (2005) . Glutathione depletion and anaesthesia in mice alter heme and drug metabolising enzymes. Biochimica et Biophysica Acta - General Subjects, 1723(1-3), 128-134.
http://dx.doi.org/10.1016/j.bbagen.2005.01.007
---------- CHICAGO ----------
Buzaleh, A.M., Batlle, A.M.D.C. "Glutathione depletion and anaesthesia in mice alter heme and drug metabolising enzymes" . Biochimica et Biophysica Acta - General Subjects 1723, no. 1-3 (2005) : 128-134.
http://dx.doi.org/10.1016/j.bbagen.2005.01.007
---------- MLA ----------
Buzaleh, A.M., Batlle, A.M.D.C. "Glutathione depletion and anaesthesia in mice alter heme and drug metabolising enzymes" . Biochimica et Biophysica Acta - General Subjects, vol. 1723, no. 1-3, 2005, pp. 128-134.
http://dx.doi.org/10.1016/j.bbagen.2005.01.007
---------- VANCOUVER ----------
Buzaleh, A.M., Batlle, A.M.D.C. Glutathione depletion and anaesthesia in mice alter heme and drug metabolising enzymes. Biochim. Biophys. Acta Gen. Subj. 2005;1723(1-3):128-134.
http://dx.doi.org/10.1016/j.bbagen.2005.01.007