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Abstract:

1. 1. The role of 5- and 6-COOH porphyrinogens III in haem biosynthesis was studied in vitro. 2. 2. When haemolysates of normal chicken erythrocytes were incubated in the presence of 5- or 6-COOH porphyrinogens III, a marked isotopic dilution was observed served on the [2-12C]glycine incorporation into haem. This effect was similar and even greater than that produced by uroporphyrinogen III and coproporphyrinogen III. To confirm these results 14C-labelled porphyrinogens of 5- and 6-COOH were incubated with chicken erythrocyte haemolysates. Labelling of the haem took place in a way similar to that when [14C]uroporphyrinogen III was used. 3. 3. These results are consistent with the idea that 5-COOH porphyrinogen III and 6-COOH porphyrinogen III are normal intermediates in haem biosynthesis with a stepwise decarboxylation process of uroporphyrinogen III to coproporphyrinogen III according to the following scheme: Uroporphyrinogen III → 7-COOH porphyrinogen III → 6-COOH porphyrinogen III → 5-COOH porphyrinogen III → coproporphyrinogen III. © 1968.

Registro:

Documento: Artículo
Título:Porphyrin biosynthesis. IV. 5- and 6-COOH porphyrinogens (type III) as normal intermediates in haem biosynthesis
Autor:San Martín De Viale, L.C.; Grinstein, M.; Grinstein, M.
Filiación:Departamento de Química Biológica, Orientación Química Biológica I. Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:carbon; glycine; heme; porphyrin; animal; article; biosynthesis; chicken; enzymology; erythrocyte; female; hemolysis; male; metabolism; rat; urine; Animal; Carbon Isotopes; Chickens; Erythrocytes; Female; Glycine; Heme; Hemolysis; Male; Porphyrins; Rats
Año:1968
Volumen:158
Número:1
Página de inicio:79
Página de fin:91
Título revista:BBA - General Subjects
Título revista abreviado:Biochim. Biophys. Acta Gen. Subj.
ISSN:03044165
CODEN:BBGSB
CAS:carbon, 7440-44-0; glycine, 56-40-6, 6000-43-7, 6000-44-8; heme, 14875-96-8; porphyrin, 24869-67-8; Carbon Isotopes; Glycine, 56-40-6; Heme, 14875-96-8; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03044165_v158_n1_p79_SanMartinDeViale

Citas:

---------- APA ----------
San Martín De Viale, L.C., Grinstein, M. & Grinstein, M. (1968) . Porphyrin biosynthesis. IV. 5- and 6-COOH porphyrinogens (type III) as normal intermediates in haem biosynthesis. BBA - General Subjects, 158(1), 79-91.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03044165_v158_n1_p79_SanMartinDeViale [ ]
---------- CHICAGO ----------
San Martín De Viale, L.C., Grinstein, M., Grinstein, M. "Porphyrin biosynthesis. IV. 5- and 6-COOH porphyrinogens (type III) as normal intermediates in haem biosynthesis" . BBA - General Subjects 158, no. 1 (1968) : 79-91.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03044165_v158_n1_p79_SanMartinDeViale [ ]
---------- MLA ----------
San Martín De Viale, L.C., Grinstein, M., Grinstein, M. "Porphyrin biosynthesis. IV. 5- and 6-COOH porphyrinogens (type III) as normal intermediates in haem biosynthesis" . BBA - General Subjects, vol. 158, no. 1, 1968, pp. 79-91.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03044165_v158_n1_p79_SanMartinDeViale [ ]
---------- VANCOUVER ----------
San Martín De Viale, L.C., Grinstein, M., Grinstein, M. Porphyrin biosynthesis. IV. 5- and 6-COOH porphyrinogens (type III) as normal intermediates in haem biosynthesis. Biochim. Biophys. Acta Gen. Subj. 1968;158(1):79-91.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03044165_v158_n1_p79_SanMartinDeViale [ ]