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Abstract:

In the rat liver, the microsomal content of cytochrome P-450 decreased by 50% after triiodothyronine (T3) administration. The molecular basis for the decreased cytochrome P-450 levels was investigated. The activities of the enzymes involved in heme synthesis or degradation were not altered by thyroid hormone administration. The incorporation of 3H-δ-aminolaevulinate into the liver microsomal heme was markedly reduced in T3-treated rats. The latter appeared not to reflect a lowered binding affinity of the apoprotein moiety of cytochrome P-450 for heme. The sodium dodecyl sulfate gel electrophoresis of the microsomal preparation showed a decrease in apocytochrome P-450. It is suggested that the amount of the apocytochrome may be the primary event affected in the formation of cytochrome P-450, by triiodothyronine treatment of thyroidectommized rats. © 1991.

Registro:

Documento: Artículo
Título:Studies on the decrease of liver cytochrome P-450 content by triiodothyronine
Autor:Kleiman de Pisarev, D.L.; Ferramola de Sancovich, A.M.; Sancovich, H.A.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Núnez, Buenos Aires, Argentina
Palabras clave:(Rat liver); Cytochrome P-450; Triiodothyronine; cytochrome p450; liothyronine; animal experiment; article; hypothyroidism; intraperitoneal drug administration; liver level; liver microsome; nonhuman; priority journal; rat; thyroidectomy; 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animal; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Heme; Human; Hydroxymethylbilane Synthase; Male; Microsomes, Liver; Porphobilinogen Synthase; Proteins; Rats; Rats, Inbred Strains; Serum Albumin; Support, Non-U.S. Gov't; Triiodothyronine; Animalia
Año:1991
Volumen:1074
Número:1
Página de inicio:172
Página de fin:177
DOI: http://dx.doi.org/10.1016/0304-4165(91)90057-N
Título revista:BBA - General Subjects
Título revista abreviado:Biochim. Biophys. Acta Gen. Subj.
ISSN:03044165
CODEN:BBGSB
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Aminolevulinic Acid, 106-60-5; Cytochrome P-450 Enzyme System, 9035-51-2; Heme, 14875-96-8; Hydroxymethylbilane Synthase, EC 4.3.1.8; Porphobilinogen Synthase, EC 4.2.1.24; Proteins; Serum Albumin; Triiodothyronine, 6893-02-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03044165_v1074_n1_p172_KleimandePisarev

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Citas:

---------- APA ----------
Kleiman de Pisarev, D.L., Ferramola de Sancovich, A.M. & Sancovich, H.A. (1991) . Studies on the decrease of liver cytochrome P-450 content by triiodothyronine. BBA - General Subjects, 1074(1), 172-177.
http://dx.doi.org/10.1016/0304-4165(91)90057-N
---------- CHICAGO ----------
Kleiman de Pisarev, D.L., Ferramola de Sancovich, A.M., Sancovich, H.A. "Studies on the decrease of liver cytochrome P-450 content by triiodothyronine" . BBA - General Subjects 1074, no. 1 (1991) : 172-177.
http://dx.doi.org/10.1016/0304-4165(91)90057-N
---------- MLA ----------
Kleiman de Pisarev, D.L., Ferramola de Sancovich, A.M., Sancovich, H.A. "Studies on the decrease of liver cytochrome P-450 content by triiodothyronine" . BBA - General Subjects, vol. 1074, no. 1, 1991, pp. 172-177.
http://dx.doi.org/10.1016/0304-4165(91)90057-N
---------- VANCOUVER ----------
Kleiman de Pisarev, D.L., Ferramola de Sancovich, A.M., Sancovich, H.A. Studies on the decrease of liver cytochrome P-450 content by triiodothyronine. Biochim. Biophys. Acta Gen. Subj. 1991;1074(1):172-177.
http://dx.doi.org/10.1016/0304-4165(91)90057-N