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Abstract:

Cystic echinococcosis is a chronic, complex, and still neglected disease. Although albendazole has demonstrated efficacy, only about one-third of patients experience complete remission or cure and 30-50% of treated patients develop some evidence of a therapeutic response. Different strategies have been developed in order to improve the albendazole water solubility and dissolution rate. The aim of the current work was to investigate the chemoprophylactic and clinical efficacy of an albendazole:poloxamer 188 solid dispersion formulation on mice infected with Echinococcus granulosus metacestodes. Albendazole formulated as solid dispersion had greater chemoprophylactic and clinical efficacy than albendazole alone. The improved in therapeutic efficacy could be a consequence of the increase in the systemic availability of albendazole sulfoxide. The work reported here demonstrates that in vivo treatment with albendazole:poloxamer 188 impairs the development of the hydatid cysts. This new pharmacotechnically based strategy could be a suitable alternative for treating cystic echinococcosis in humans. © 2014 Elsevier B.V.

Registro:

Documento: Artículo
Título:Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis
Autor:Pensel, P.E.; Castro, S.; Allemandi, D.; Bruni, S.S.; Palma, S.D.; Elissondo, M.C.
Filiación:Laboratorio de Zoonosis Parasitarias, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Argentina
Laboratorio de Farmacotecnia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, UNITEFA, Argentina
Laboratorio de Farmacología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, CIVETAN, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
Palabras clave:Albendazole; Cystic echinococcosis; Echinococcus granulosus; Solid dispersions; albendazole sulfoxide; placebo; poloxamer; animal experiment; animal model; animal tissue; anthelmintic activity; article; clinical effectiveness; controlled study; drug bioavailability; drug efficacy; drug formulation; echinococcosis; Echinococcus granulosus; in vivo study; infection prevention; metacestode; microbial morphology; mouse; nonhuman; parasite identification; treatment outcome; Albendazole; Cystic echinococcosis; Echinococcus granulosus; Solid dispersions; Albendazole; Animals; Anthelmintics; Chemoprevention; Echinococcosis; Echinococcus granulosus; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Poloxamer; Treatment Outcome
Año:2014
Volumen:203
Número:1-2
Página de inicio:80
Página de fin:86
DOI: http://dx.doi.org/10.1016/j.vetpar.2014.01.027
Título revista:Veterinary Parasitology
Título revista abreviado:Vet. Parasitol.
ISSN:03044017
CODEN:VPARD
CAS:albendazole sulfoxide, 54029-12-8; poloxamer, 9003-11-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03044017_v203_n1-2_p80_Pensel

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Citas:

---------- APA ----------
Pensel, P.E., Castro, S., Allemandi, D., Bruni, S.S., Palma, S.D. & Elissondo, M.C. (2014) . Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis. Veterinary Parasitology, 203(1-2), 80-86.
http://dx.doi.org/10.1016/j.vetpar.2014.01.027
---------- CHICAGO ----------
Pensel, P.E., Castro, S., Allemandi, D., Bruni, S.S., Palma, S.D., Elissondo, M.C. "Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis" . Veterinary Parasitology 203, no. 1-2 (2014) : 80-86.
http://dx.doi.org/10.1016/j.vetpar.2014.01.027
---------- MLA ----------
Pensel, P.E., Castro, S., Allemandi, D., Bruni, S.S., Palma, S.D., Elissondo, M.C. "Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis" . Veterinary Parasitology, vol. 203, no. 1-2, 2014, pp. 80-86.
http://dx.doi.org/10.1016/j.vetpar.2014.01.027
---------- VANCOUVER ----------
Pensel, P.E., Castro, S., Allemandi, D., Bruni, S.S., Palma, S.D., Elissondo, M.C. Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis. Vet. Parasitol. 2014;203(1-2):80-86.
http://dx.doi.org/10.1016/j.vetpar.2014.01.027