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Abstract:

Recent neuroimaging studies have demonstrated that the spontaneous brain activity reflects, to a large extent, the same activation patterns measured in response to cognitive and behavioral tasks. This correspondence between activation and rest has been explored with a large repertoire of computational methods, ranging from analysis of pairwise interactions between areas of the brain to the global brain networks yielded by independent component analysis. In this paper we describe an alternative method based on the averaging of the BOLD signal at a region of interest (target) triggered by spontaneous increments in activity at another brain area (seed). The resting BOLD event triggered averages (" rBeta") can be used to estimate functional connectivity at resting state. Using two simple examples, here we illustrate how the analysis of the average response triggered by spontaneous increases/decreases in the BOLD signal is sufficient to capture the aforementioned correspondence in a variety of circumstances. The computation of the non linear response during rest here described allows for a direct comparison with results obtained during task performance, providing an alternative measure of functional interaction between brain areas. © 2010 Elsevier Ireland Ltd.

Registro:

Documento: Artículo
Título:Spontaneous BOLD event triggered averages for estimating functional connectivity at resting state
Autor:Tagliazucchi, E.; Balenzuela, P.; Fraiman, D.; Montoya, P.; Chialvo, D.R.
Filiación:Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Tecnologicas (CONICET), Buenos Aires, Argentina
Departamento de Matemática y Ciencias, Universidad de San Andres, Buenos Aires, Argentina
University Institute of Health Sciences Research (IUNICS), University of Balearic Islands (UIB), Palma, Spain
Department of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States
Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario 2000, Argentina
Palabras clave:Functional connectivity; Functional magnetic resonance imaging; Resting state; Triggered averages; adult; aged; article; behavior; brain mapping; brain oxygen tension; brain region; clinical article; cognition; computational fluid dynamics; controlled study; electroencephalogram; functional magnetic resonance imaging; human; human experiment; nerve cell network; neuroimaging; normal human; priority journal; rest; signal transduction; task performance; Adult; Aged; Back Pain; Brain; Brain Mapping; Chronic Disease; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Middle Aged; Neural Pathways; Rest; Young Adult
Año:2011
Volumen:488
Número:2
Página de inicio:158
Página de fin:163
DOI: http://dx.doi.org/10.1016/j.neulet.2010.11.020
Título revista:Neuroscience Letters
Título revista abreviado:Neurosci. Lett.
ISSN:03043940
CODEN:NELED
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v488_n2_p158_Tagliazucchi

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Citas:

---------- APA ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Montoya, P. & Chialvo, D.R. (2011) . Spontaneous BOLD event triggered averages for estimating functional connectivity at resting state. Neuroscience Letters, 488(2), 158-163.
http://dx.doi.org/10.1016/j.neulet.2010.11.020
---------- CHICAGO ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Montoya, P., Chialvo, D.R. "Spontaneous BOLD event triggered averages for estimating functional connectivity at resting state" . Neuroscience Letters 488, no. 2 (2011) : 158-163.
http://dx.doi.org/10.1016/j.neulet.2010.11.020
---------- MLA ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Montoya, P., Chialvo, D.R. "Spontaneous BOLD event triggered averages for estimating functional connectivity at resting state" . Neuroscience Letters, vol. 488, no. 2, 2011, pp. 158-163.
http://dx.doi.org/10.1016/j.neulet.2010.11.020
---------- VANCOUVER ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Montoya, P., Chialvo, D.R. Spontaneous BOLD event triggered averages for estimating functional connectivity at resting state. Neurosci. Lett. 2011;488(2):158-163.
http://dx.doi.org/10.1016/j.neulet.2010.11.020