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Abstract:

Estradiol treatment of ovariectomized rats resulted in a significant increase in β-adrenoceptor density in the medial basal hypothalamus (MBH) without affecting the affinity for the radioactive ligand. Neither MBH α-adrenoceptors nor α- or β-adrenoceptors in the cerebral cortex, or β-adrenoceptors in the pineal gland, were affected by estradiol injection. © 1980.

Registro:

Documento: Artículo
Título:Effect of estradiol on α and β-adrenoceptor density in medial basal hypothalamus, cerebral cortex and pineal gland of ovariectomized rats
Autor:Vacas, M.I.; Cardineli, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN) V. de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:alpha adrenergic receptor; beta adrenergic receptor; drug receptor; drug vehicle; estradiol; ethinylestradiol; gonadotropin; prolactin; radioisotope; animal experiment; brain cortex; central nervous system; dihydroalprenolol h 3; dihydroergocryptine h 3; dose response; drug administration; drug binding; drug comparison; drug dose; drug response; feedback system; female genital system; hypothalamus; ovariectomy; ovulation regulation; pineal body; proestrus; radioimmunoassay; rat; sexual behavior; short survey; Animal; Brain; Castration; Cerebral Cortex; Estradiol; Female; Hypothalamus, Middle; Ovary; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Support, Non-U.S. Gov't
Año:1980
Volumen:17
Número:1-2
Página de inicio:73
Página de fin:77
DOI: http://dx.doi.org/10.1016/0304-3940(80)90064-6
Título revista:Neuroscience Letters
Título revista abreviado:Neurosci. Lett.
ISSN:03043940
CODEN:NELED
CAS:estradiol, 50-28-2; ethinylestradiol, 57-63-6; gonadotropin, 63231-54-9; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; Estradiol, 50-28-2; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v17_n1-2_p73_Vacas

Referencias:

  • Caligar, Astrada, Taleisnik, Release of luteinizing hormone induced by estrogen injection into ovariectomized rats (1971) endocrinology, 88, pp. 810-815
  • Cardinali, Models in neuroendocrinology, Neurohumoral pathways to the pineal gland (1979) Trends Neurosci., 2, pp. 250-253
  • Cardinali, Gomez, Changes in hypothalamic noradrenaline, dopamine and serotonin uptake after oestradiol administration to rats (1977) J. Endocrinol., 73, pp. 181-182
  • Lowry, Rosebrough, Farr, Randall, Protein measurement eith the Folin phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Roberts, Goldfien, Tsuchiya, Goldfien, Insel, Estrogen treatment decreases α-adrenergic binding sites on rabbit platelets (1979) Endocrinology, 104, pp. 722-728
  • Roberts, Insel, Goldfien, Goldfien, Alpha-adrenoceptors but not β-adrenoceptors increase in rabbit uterus with oestrogen (1977) Nature (Lond.), 270, pp. 624-625
  • Sawyer, Markee, Everett, The mechanism by which dibenamine blocks pituitary activities in the rabbit and the rat (1949) Experimental Biology and Medicine, 71, pp. 670-672. , 3rd edn
  • Wagner, Crutcher, Davis, Chronic estrogen treatment decreases β-adrenergic responses in rat cerebral cortex (1979) Brain Res., 171, pp. 147-151
  • Weiner, Ganong, Role of brain monoamines and histamine in regulation of anterior pituitary secretion (1978) Physiol. Rev., 58, pp. 905-976
  • Weiss, Crayton, Gonadal hormones as regulators of pineal adenyl cyclase activity (1970) Endocrinology, 87, pp. 527-533
  • Wilkinson, Herdon, Pearce, Wilson, Radioligand binding studies on hypothalamic noradrenergic receptors during the estrous cycle or after steroid injection in ovariectomized rats (1979) Brain Res., 168, pp. 652-655
  • Williams, Lefkowitz, (1978) Receptor Binding Studies in Adrenergic Pharmacology, p. 157. , Raven Press, New York
  • Williams, Lefkowitz, Regulation of rabbit myometrial α-adrenergic receptors by estrogen and progesterone (1977) J. Clin. Invest., 60, pp. 815-818
  • Zats, Kebabian, Romero, Lefkowitz, Axelrod, Pineal β-adrenergic receptor: correlation of binding of 3H-alprenolol with stimulation of adrenylate cyclase (1976) J. Pharmacol. exp. Ther., 196, pp. 714-722

Citas:

---------- APA ----------
Vacas, M.I. & Cardineli, D.P. (1980) . Effect of estradiol on α and β-adrenoceptor density in medial basal hypothalamus, cerebral cortex and pineal gland of ovariectomized rats. Neuroscience Letters, 17(1-2), 73-77.
http://dx.doi.org/10.1016/0304-3940(80)90064-6
---------- CHICAGO ----------
Vacas, M.I., Cardineli, D.P. "Effect of estradiol on α and β-adrenoceptor density in medial basal hypothalamus, cerebral cortex and pineal gland of ovariectomized rats" . Neuroscience Letters 17, no. 1-2 (1980) : 73-77.
http://dx.doi.org/10.1016/0304-3940(80)90064-6
---------- MLA ----------
Vacas, M.I., Cardineli, D.P. "Effect of estradiol on α and β-adrenoceptor density in medial basal hypothalamus, cerebral cortex and pineal gland of ovariectomized rats" . Neuroscience Letters, vol. 17, no. 1-2, 1980, pp. 73-77.
http://dx.doi.org/10.1016/0304-3940(80)90064-6
---------- VANCOUVER ----------
Vacas, M.I., Cardineli, D.P. Effect of estradiol on α and β-adrenoceptor density in medial basal hypothalamus, cerebral cortex and pineal gland of ovariectomized rats. Neurosci. Lett. 1980;17(1-2):73-77.
http://dx.doi.org/10.1016/0304-3940(80)90064-6