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Abstract:

A diurnal variation in neuroendocrine sensitivity to melatonin is known to occur in hamsters and rats. The present experiments were carried out to examine the possibility that affinity and/or number of melatonin binding sites in brain could change accordingly at the two times when exogenous melatonin is known to be ineffective or effective to produce neuroendocrine changes, i.e., at 07 : 00 or 20 : 00 h (lights on from 07 : 00 to 21 : 00 h daily). The number of melatonin binding sites in hamster and rat brains was at 20 : 00 h 34-56% higher than at 07 : 00 h, without changing their affinity towards [3H]melatonin (hamster: Kd = 53 nM; rat: Kd = 73-77 nM). These alterations in melatonin receptor density may play a role in daily changes in sensitivity to the exogenous methoxyindole. © 1979.

Registro:

Documento: Artículo
Título:Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin
Autor:Vacas, M.I.; Cardinali, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Obligado 2490, 1423 Buenos Aires, Argentina
Palabras clave:tritium; animal experiment; bernard soulier disease; brain; central nervous system; circadian rhythm; drug binding; hamster; in vitro study; melatonin h 3; radioimmunoassay; rat; Animal; Brain Chemistry; Circadian Rhythm; Comparative Study; Hamsters; Light; Male; Melatonin; Rats; Receptors, Cell Surface; Species Specificity
Año:1979
Volumen:15
Número:2-3
Página de inicio:259
Página de fin:263
DOI: http://dx.doi.org/10.1016/0304-3940(79)96123-8
Título revista:Neuroscience Letters
Título revista abreviado:Neurosci. Lett.
ISSN:03043940
CODEN:NELED
CAS:tritium, 10028-17-8; Melatonin, 73-31-4; Receptors, Cell Surface
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v15_n2-3_p259_Vacas

Referencias:

  • Bittman, Hamster refractoriness: the role of insensitivity of pineal target tissues (1978) Science, 202, pp. 648-650
  • Cardinali, Vacas, Estevez-Boyer, High affinity binding of melatonin in bovine medial basal hypothalamus (1978) IRCS Medical Sci., 6, p. 357
  • Cardinali, Vacas, Estevez-Boyer, Specific binding of melatonin in bovine brain (1979) Endocrinology, , in press
  • Fiske, Huppert, Melatonin action on pineal varies with photoperiod (1978) Science, 202, pp. 648-650
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Reiter, Blask, Johnson, Rudeem, Vaughan, Waring, Melatonin inhibition of reproduction in the male hamster: its dependency on time of day of administration and on an intact and sympathetically innervated pineal gland (1976) Neuroendocrinology, 22, pp. 107-116
  • Reiter, Rudeen, Sackman, Vaughan, Johnson, Little, Subcutaneous melatonin implants inhibit reproductive atrophy in male hamsters induced by daily melatonin injections (1977) Endocr. Res. Comm., 4, pp. 35-44
  • Scatchard, The attraction of proteins for small molecules and ions (1949) Annals of the New York Academy of Sciences, 51, pp. 660-670
  • Tamarkin, Hollister, Lefebvre, Goldman, Melatonin induction of gonadal quiescence in pinealectomized Syrian hamsters (1977) Science, 198, pp. 953-955
  • Tamarkin, Reppert, Klein, Regulation of pineal melatonin in the Syrian hamster (1979) Endocrinology, 104, pp. 385-389
  • Wilkinson, Arendt, Bradkte, de Ziegler, Determination of a dark-induced increase of pineal N-acetyl transferase activity and simultaneous radioimmunoassay of melatonin in pineal, serum and pituitary tissue of the male rat (1977) J. Endocrinol., 72, pp. 243-244

Citas:

---------- APA ----------
Vacas, M.I. & Cardinali, D.P. (1979) . Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin. Neuroscience Letters, 15(2-3), 259-263.
http://dx.doi.org/10.1016/0304-3940(79)96123-8
---------- CHICAGO ----------
Vacas, M.I., Cardinali, D.P. "Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin" . Neuroscience Letters 15, no. 2-3 (1979) : 259-263.
http://dx.doi.org/10.1016/0304-3940(79)96123-8
---------- MLA ----------
Vacas, M.I., Cardinali, D.P. "Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin" . Neuroscience Letters, vol. 15, no. 2-3, 1979, pp. 259-263.
http://dx.doi.org/10.1016/0304-3940(79)96123-8
---------- VANCOUVER ----------
Vacas, M.I., Cardinali, D.P. Diurnal changes in melatonin binding sites of hamster and rat brains. Correlation with neuroendocrine responsiveness to melatonin. Neurosci. Lett. 1979;15(2-3):259-263.
http://dx.doi.org/10.1016/0304-3940(79)96123-8