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Abstract:

The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport. © 1979.

Registro:

Documento: Artículo
Título:Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles
Autor:Prevedello, M.R.; Ritta, M.N.; Cardinali, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:5 hydroxyindoleacetic acid; 5 methoxyindoleacetic acid; 5 methoxytryptamine; indole; melatonin; n acetylserotonin; radioisotope; serotonin; tryptamine; vinblastine; 5 methylindoleacetic acid; animal experiment; axoplasm flow; in vitro study; leucine h 3; nervous system; peripheral nervous system; rat; sciatic nerve; 5-Methoxytryptamine; Animal; Axonal Transport; Comparative Study; Hydroxyindoleacetic Acid; Indoleacetic Acids; Indoles; Male; Melatonin; Nerve Tissue Proteins; Pentoxifylline; Peripheral Nerves; Pineal Gland; Rats; Serotonin
Año:1979
Volumen:13
Número:1
Página de inicio:29
Página de fin:34
DOI: http://dx.doi.org/10.1016/0304-3940(79)90070-3
Título revista:Neuroscience Letters
Título revista abreviado:Neurosci. Lett.
ISSN:03043940
CODEN:NELED
CAS:5 hydroxyindoleacetic acid, 1321-73-9, 54-16-0; 5 methoxyindoleacetic acid, 3471-31-6; 5 methoxytryptamine, 608-07-1, 66-83-1; indole, 120-72-9; melatonin, 73-31-4; n acetylserotonin, 17994-17-1; serotonin, 50-67-9; tryptamine, 343-94-2, 61-54-1; vinblastine, 865-21-4; 5-Methoxytryptamine, 608-07-1; Hydroxyindoleacetic Acid, 54-16-0; Indoleacetic Acids; Indoles; Melatonin, 73-31-4; Nerve Tissue Proteins; Pentoxifylline, 6493-05-6; Serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v13_n1_p29_Prevedello

Referencias:

  • Barchas, Lerner, Localization of melatonin in the nervous system (1964) J. Neurochem., 11, pp. 489-491
  • Cardinali, Melatonin and the endocrine role of the pineal organ (1974) Current Topics in Experimental Endocrinology, 2, pp. 107-128. , V.H.T. James, L. Martini, Academic Press, New York
  • Cardinali, Effects of pentoxifylline and theophylline on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus (1977) Neuropharmacology, 16, pp. 785-790
  • Cardinali, Freire, Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formations in the hypothalamus (1975) Mol. cell. Endocrinol., 2, pp. 317-330
  • Edström, Hanson, The mechanisms of fast axonal transport: a pharmacological approach (1975) Neuropharmacology, 14, pp. 181-188
  • Edström, Mattson, Fast axonal transport in the sciatic system of the frog (1972) Journal of Neurochemistry, 19, pp. 205-221
  • Freire, Cardinali, Effects of melatonin treatment and environmental lighting on the ultrastructural appearance melatonin synthesis, norepinephrine turnover and microtubule protein content of the pineal gland (1975) J. neural. Trans., 37, pp. 237-257
  • Hall, Gregson, The in vivo and ultrastructural effects of injection of lysophosphatidyl choline into myelinated peripheral nerve fibres of the adult mouse (1971) J. Cell Sci., 9, pp. 769-789
  • Hedlund, Lischko, Rollag, Niswender, Melatonin daily cycle in plasma and cerebrospinal fluid of calves (1977) Science, 195, pp. 686-687
  • Reiter, (1977) The Pineal-1977, p. 184. , Eden Press, Montreal
  • Valenti, Cardinali, Gimeno, Gimeno, Actividat mecánica inducida por estimulación eléctrica del nervio ciático aislado de rats. Influencia de vinblastina, colchicina y melatonina. Interrelaciones con la concentraión de tubulina axonal total (1977) Medicina (Buenos Aires), 37, pp. 552-553

Citas:

---------- APA ----------
Prevedello, M.R., Ritta, M.N. & Cardinali, D.P. (1979) . Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles. Neuroscience Letters, 13(1), 29-34.
http://dx.doi.org/10.1016/0304-3940(79)90070-3
---------- CHICAGO ----------
Prevedello, M.R., Ritta, M.N., Cardinali, D.P. "Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles" . Neuroscience Letters 13, no. 1 (1979) : 29-34.
http://dx.doi.org/10.1016/0304-3940(79)90070-3
---------- MLA ----------
Prevedello, M.R., Ritta, M.N., Cardinali, D.P. "Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles" . Neuroscience Letters, vol. 13, no. 1, 1979, pp. 29-34.
http://dx.doi.org/10.1016/0304-3940(79)90070-3
---------- VANCOUVER ----------
Prevedello, M.R., Ritta, M.N., Cardinali, D.P. Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles. Neurosci. Lett. 1979;13(1):29-34.
http://dx.doi.org/10.1016/0304-3940(79)90070-3