Artículo

Wainstok de Calmanovici, R.; Cochón, A.C.; Zenklusen, J.C.; Aldonatti, C.; Cabral, J.R.P.; San Martín de Viale, L.C. "Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats" (1991) Cancer Letters. 58(3):225-232
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Abstract:

The response of female BDVI rats bearing diethylnitrosamine (DENA)-induced hepatic tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. (1) The heme pathway operates in these tumors but they were less affected by HCB than the liver. (2) Tumors did not accumulate porphyrins although the surrounding liver accumulated more porphyrins than livers treated with HCB. (3) DENA HCB livers which developed a well defined tumor showed slightly less porphyrinogen carboxylyase inhibition and δ-aminolaevulinate synthase induction than HCB rats. (4) The results of the present work suggest that endogenously formed porphyrins would be unable to be accumulated by DENA-induced tumors when the tumoral development precedes the onset of the porphyria. © 1991.

Registro:

Documento: Artículo
Título:Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats
Autor:Wainstok de Calmanovici, R.; Cochón, A.C.; Zenklusen, J.C.; Aldonatti, C.; Cabral, J.R.P.; San Martín de Viale, L.C.
Filiación:Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Núñez 1428, Buenos Aires, Argentina
International Agency for Research on Cancer, Lyon, France
Palabras clave:diethylnitrosamine; hepatocarcinoma; hexachlorobenzene; porphyria; porphyrins; diethylnitrosamine; hexachlorobenzene; animal model; article; controlled study; liver tumor; porphyria; priority journal; rat; 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animal; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Female; Ferrochelatase; Hexachlorobenzene; Liver; Liver Neoplasms; Porphobilinogen; Porphyria; Porphyrins; Rats; Support, Non-U.S. Gov't
Año:1991
Volumen:58
Número:3
Página de inicio:225
Página de fin:232
DOI: http://dx.doi.org/10.1016/0304-3835(91)90105-Q
Título revista:Cancer Letters
Título revista abreviado:Cancer Lett.
ISSN:03043835
CODEN:CALED
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Aminolevulinic Acid, 106-60-5; Cytochrome P-450 Enzyme System, 9035-51-2; Diethylnitrosamine, 55-18-5; Ferrochelatase, EC 4.99.1.1; Hexachlorobenzene, 118-74-1; Porphobilinogen, 487-90-1; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043835_v58_n3_p225_WainstokdeCalmanovici

Referencias:

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Citas:

---------- APA ----------
Wainstok de Calmanovici, R., Cochón, A.C., Zenklusen, J.C., Aldonatti, C., Cabral, J.R.P. & San Martín de Viale, L.C. (1991) . Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats. Cancer Letters, 58(3), 225-232.
http://dx.doi.org/10.1016/0304-3835(91)90105-Q
---------- CHICAGO ----------
Wainstok de Calmanovici, R., Cochón, A.C., Zenklusen, J.C., Aldonatti, C., Cabral, J.R.P., San Martín de Viale, L.C. "Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats" . Cancer Letters 58, no. 3 (1991) : 225-232.
http://dx.doi.org/10.1016/0304-3835(91)90105-Q
---------- MLA ----------
Wainstok de Calmanovici, R., Cochón, A.C., Zenklusen, J.C., Aldonatti, C., Cabral, J.R.P., San Martín de Viale, L.C. "Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats" . Cancer Letters, vol. 58, no. 3, 1991, pp. 225-232.
http://dx.doi.org/10.1016/0304-3835(91)90105-Q
---------- VANCOUVER ----------
Wainstok de Calmanovici, R., Cochón, A.C., Zenklusen, J.C., Aldonatti, C., Cabral, J.R.P., San Martín de Viale, L.C. Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats. Cancer Lett. 1991;58(3):225-232.
http://dx.doi.org/10.1016/0304-3835(91)90105-Q