Artículo

Wainstok de Calmanovici, R.; Cochón, A.C.; Aldonatti, C.; Bergoc, R.; San Martín de Viala, L.C. "Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats" (1990) Cancer Letters. 55(1):67-73
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Abstract:

The response of animals bearing N-nitroso-N-methylurea (NMU)-induced mammary tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. δ-Aminolevulinic acid (ALA), porphobilinogen and porphyrins in urine, ALA-synthase and porphyrinogen carboxylyase activities and porphyrin content in liver and tumor were measured. The results obtained indicate that the metabolic heme pathway operates in mammary tumors but tumor response to HCB treatment could not be detected. HCB administration produced an earlier and greater hepatic porphyria in tumor-bearing rats than in healthy rats suggesting that the presence of tumors exacerbates the action of HCB. © 1990.

Registro:

Documento: Artículo
Título:Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats
Autor:Wainstok de Calmanovici, R.; Cochón, A.C.; Aldonatti, C.; Bergoc, R.; San Martín de Viala, L.C.
Filiación:Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Nunez 1428, 1113 Buenos Aires, Argentina
Laboratorio de Radioisótopos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 954, 1113 Buenos Aires, Argentina
Palabras clave:heme pathway; hexachlorobenzene; mammary tumor; N-nitroso-N-methylurea; porphyrins; porphyris; hexachlorobenzene; methylnitrosourea; animal experiment; article; breast; breast tumor; controlled study; female; nonhuman; porphyria; priority journal; rat; 5-Aminolevulinate Synthetase; Animal; Female; Hexachlorobenzene; Mammary Neoplasms, Experimental; Porphyria; Porphyrins; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Animalia
Año:1990
Volumen:55
Número:1
Página de inicio:67
Página de fin:73
DOI: http://dx.doi.org/10.1016/0304-3835(90)90067-8
Título revista:Cancer Letters
Título revista abreviado:Cancer Lett.
ISSN:03043835
CODEN:CALED
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Hexachlorobenzene, 118-74-1; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043835_v55_n1_p67_WainstokdeCalmanovici

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Citas:

---------- APA ----------
Wainstok de Calmanovici, R., Cochón, A.C., Aldonatti, C., Bergoc, R. & San Martín de Viala, L.C. (1990) . Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats. Cancer Letters, 55(1), 67-73.
http://dx.doi.org/10.1016/0304-3835(90)90067-8
---------- CHICAGO ----------
Wainstok de Calmanovici, R., Cochón, A.C., Aldonatti, C., Bergoc, R., San Martín de Viala, L.C. "Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats" . Cancer Letters 55, no. 1 (1990) : 67-73.
http://dx.doi.org/10.1016/0304-3835(90)90067-8
---------- MLA ----------
Wainstok de Calmanovici, R., Cochón, A.C., Aldonatti, C., Bergoc, R., San Martín de Viala, L.C. "Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats" . Cancer Letters, vol. 55, no. 1, 1990, pp. 67-73.
http://dx.doi.org/10.1016/0304-3835(90)90067-8
---------- VANCOUVER ----------
Wainstok de Calmanovici, R., Cochón, A.C., Aldonatti, C., Bergoc, R., San Martín de Viala, L.C. Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats. Cancer Lett. 1990;55(1):67-73.
http://dx.doi.org/10.1016/0304-3835(90)90067-8