Abstract:
The effect of adenohypophysial hormones on rat pineal melatonin content and release was examined in vitro. Medium concentration of radioimmunoassayable melatonin decreased after a 6 h exposure to 1-100 ng/ml FSH; pineal levels of melatonin were only decreased by 100 ng/ml FSH. LH (1-100 ng/ml) augmented significantly medium melatonin concentration, tissue levels being increased at 10 ng/ml LH. Parallel increases of explant and medium melatonin content were found after exposure to 1-100 ng/ml TSH. At the smallest concentration employed (1 ng/ml) prolactin increased melatonin content and release while at 100 ng/ml a significant depression of both parameters was found. Growth hormone (1-10 ng/ml) augmented melatonin levels in medium but failed to modify them at 100 ng/ml, although at this concentration tissue melatonin levels increased. ACTH did not modify pineal melatonin synthesis in vitro. © 1987.
Registro:
Documento: |
Artículo
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Título: | In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release |
Autor: | Vacas, M.I.; Sarmiento, M.I.K.; Pereyra, E.N.; Etchegoyen, G.S.; Cardinali, D.P. |
Filiación: | Centro de Estudios Farmacológicos v de Principios Naturales (CEFAPRIN), Serrano 665, 1414 Buenos Aires, Argentina
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Palabras clave: | ACTH; FSH; Growth hormone; LH; Pineal organ culture; Prolactin; TSH; adenohypophysis hormone; corticotropin; follitropin; growth hormone; luteinizing hormone; melatonin; prolactin; radioisotope; thyrotropin; animal experiment; central nervous system; drug administration; drug comparison; drug dose; drug efficacy; endocrine system; in vitro study; methodology; nonhuman; pineal body; preliminary communication; priority journal; radioimmunoassay; rat; Adrenocorticotropic Hormone; Animals; Follicle Stimulating Hormone; Growth Hormone; Luteinizing Hormone; Male; Melatonin; Organ Culture Techniques; Pineal Gland; Pituitary Hormones, Anterior; Prolactin; Rats; Thyrotropin |
Año: | 1987
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Volumen: | 50
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Número: | 1-2
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Página de inicio: | 23
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Página de fin: | 27
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DOI: |
http://dx.doi.org/10.1016/0303-7207(87)90073-6 |
Título revista: | Molecular and Cellular Endocrinology
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Título revista abreviado: | Mol. Cell. Endocrinol.
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ISSN: | 03037207
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CODEN: | MCEND
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CAS: | corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; follitropin, 9002-68-0; growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; luteinizing hormone, 39341-83-8, 9002-67-9; melatonin, 73-31-4; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; thyrotropin, 9002-71-5; Adrenocorticotropic Hormone, 9002-60-2; Follicle Stimulating Hormone, 9002-68-0; Growth Hormone, 9002-72-6; Luteinizing Hormone, 9002-67-9; Melatonin, 73-31-4; Pituitary Hormones, Anterior; Prolactin, 9002-62-4; Thyrotropin, 9002-71-5
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v50_n1-2_p23_Vacas |
Referencias:
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Citas:
---------- APA ----------
Vacas, M.I., Sarmiento, M.I.K., Pereyra, E.N., Etchegoyen, G.S. & Cardinali, D.P.
(1987)
. In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release. Molecular and Cellular Endocrinology, 50(1-2), 23-27.
http://dx.doi.org/10.1016/0303-7207(87)90073-6---------- CHICAGO ----------
Vacas, M.I., Sarmiento, M.I.K., Pereyra, E.N., Etchegoyen, G.S., Cardinali, D.P.
"In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release"
. Molecular and Cellular Endocrinology 50, no. 1-2
(1987) : 23-27.
http://dx.doi.org/10.1016/0303-7207(87)90073-6---------- MLA ----------
Vacas, M.I., Sarmiento, M.I.K., Pereyra, E.N., Etchegoyen, G.S., Cardinali, D.P.
"In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release"
. Molecular and Cellular Endocrinology, vol. 50, no. 1-2, 1987, pp. 23-27.
http://dx.doi.org/10.1016/0303-7207(87)90073-6---------- VANCOUVER ----------
Vacas, M.I., Sarmiento, M.I.K., Pereyra, E.N., Etchegoyen, G.S., Cardinali, D.P. In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release. Mol. Cell. Endocrinol. 1987;50(1-2):23-27.
http://dx.doi.org/10.1016/0303-7207(87)90073-6