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Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box transcription factor 1 (FOXO1) in the induction of these alterations. The heart from adult offspring from control and streptozotocin-induced diabetic rats was evaluated. Increased glycemia, triglyceridemia and insulinemia and markers of cardiomyopathy were found in the offspring from diabetic rats. In the heart, an increase in active FOXO1 and mRNA levels of its target genes, Mmp-2 and Ctgf, genes related to an altered extracellular matrix remodeling, together with an increase in collagen deposition and a decrease in the connexin43 levels, were found in the offspring from diabetic rats. Altogether, these results suggest an important role of FOXO1 activation in the cardiac alterations induced by intrauterine programming in maternal diabetes. © 2018


Documento: Artículo
Título:Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
Autor:Musikant, D.; Sato, H.; Capobianco, E.; White, V.; Jawerbaum, A.; Higa, R.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
Universidad de Buenos Aires, Facultad de Medicina, Argentina
CONICET-Universidad de Buenos Aires, Laboratory of Reproduction and Metabolism, CEFYBO, Buenos Aires, Argentina
Palabras clave:Connexin43; Diabetes; FOXO1; Heart; Intrauterine programming; Matrix metalloproteinases; collagen; connexin 43; messenger RNA; streptozocin; transcription factor FKHR; adult; animal experiment; animal model; animal tissue; Article; cardiomyopathy; cardiovascular parameters; controlled study; Ctgf gene; enzyme activation; extracellular matrix; female; gene; gene targeting; heart; hyperglycemia; hypertriglyceridemia; insulinemia; male; maternal diabetes mellitus; Mmp 2 gene; nonhuman; pathogenesis; priority journal; progeny; protein function; rat
Página de inicio:78
Página de fin:86
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
CAS:collagen, 9007-34-5; streptozocin, 18883-66-4


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---------- APA ----------
Musikant, D., Sato, H., Capobianco, E., White, V., Jawerbaum, A. & Higa, R. (2019) . Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes. Molecular and Cellular Endocrinology, 479, 78-86.
---------- CHICAGO ----------
Musikant, D., Sato, H., Capobianco, E., White, V., Jawerbaum, A., Higa, R. "Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes" . Molecular and Cellular Endocrinology 479 (2019) : 78-86.
---------- MLA ----------
Musikant, D., Sato, H., Capobianco, E., White, V., Jawerbaum, A., Higa, R. "Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes" . Molecular and Cellular Endocrinology, vol. 479, 2019, pp. 78-86.
---------- VANCOUVER ----------
Musikant, D., Sato, H., Capobianco, E., White, V., Jawerbaum, A., Higa, R. Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes. Mol. Cell. Endocrinol. 2019;479:78-86.