Navegar

Colección

Datos Estadísticas

Artículo

El editor solo permite decargar el artículo en su versión post-print desde el repositorio. Por favor, si usted posee dicha versión, enviela a
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The present study examined the effects of streptozotocin-induced diabetes on prolactin (Prl) secretion and its correlation with estrogen receptor levels in the anterior pituitary and hypothalamus. Prl was measured in adult ovariectomized rats and after treatment (10 μg estradiol benzoate (Eb) 48.24 and 1 h before experiments) or acute TRH administration (4 μg/kg body weight). Substantial decreases in estradiol- and TRH-induced Prl release were observed in diabetic rats. Insulin therapy was able to restore this response. Measurement of nuclear estradiol receptors by exchange assay in the pituitary of Eb-treated rats revealed a significant reduction in receptor levels in the diabetic group and a restoration to normal values in insulin-treated diabetic rats. Similar results were obtained by measuring total pituitary receptor content (cytosolic plus nuclear receptor). No significant changes were observed observed in nuclear hypothalamic estradiol receptors. However, the number of total hypothalamic estradiol receptors was diminished in diabetic rats although the translocation was proportionally greater in these animals. These results indicate that the disrupted reproductive functions described in streptozotocin diabetic rats may be due, at least in part, to deficiencies in Prl secretions and pituitary estradiol action. © 1985.

Registro:

Documento: Artículo
Título:Alterations in the prolactin secretion in streptozotocin-induced diabetic rats. Correlation with pituitary and hypothalamus estradiol receptors
Autor:Tesone, M.; Ladenheim, R.G.; Charreau, E.H.
Filiación:Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina
Palabras clave:diabetic rats; estradiol receptors; prolactin; estradiol benzoate; estradiol receptor; insulin; protirelin; radioisotope; streptozocin; animal cell; animal experiment; animal model; central nervous system; drug mechanism; drug receptor binding; drug sensitivity; endocrine system; estradiol h 3; etiology; female genital system; hypophysis; hypothalamus; intravenous drug administration; nonhuman; ovariectomy; pancreas; pharmacokinetics; priority journal; prolactin release; rat; reproduction; streptozocin diabetes; subcutaneous drug administration; therapy; Animal; Diabetes Mellitus, Experimental; Estradiol; Female; Hypothalamus; Insulin; Ovariectomy; Pituitary Gland; Prolactin; Protirelin; Rats; Rats, Inbred Strains; Receptors, Estradiol; Receptors, Estrogen; Support, Non-U.S. Gov't
Año:1985
Volumen:43
Número:2-3
Página de inicio:135
Página de fin:140
DOI: http://dx.doi.org/10.1016/0303-7207(85)90076-0
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
ISSN:03037207
CODEN:MCEND
CAS:estradiol benzoate, 50-50-0; insulin, 9004-10-8; protirelin, 24305-27-9; streptozocin, 18883-66-4; Estradiol, 50-28-2; Insulin, 11061-68-0; Prolactin, 9002-62-4; Protirelin, 24305-27-9; Receptors, Estradiol; Receptors, Estrogen
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v43_n2-3_p135_Tesone

Referencias:

  • Becú, Libertun, (1982) Endocrinology, 110, pp. 1879-1884
  • Bluet-Pajot, Durand, Kordon, (1983) Neuroendocrinology, 36, pp. 307-309
  • Boler, Enzman, Folkers, Bowers, Shally, (1969) Biochem. Biophys. Res. Commun., 37, pp. 705-710
  • Burton, (1956) Biochem. J., 62, pp. 315-323
  • Chen, Meites, (1975) Endocrinology, 96, pp. 10-14
  • Clark, (1984) Trends Biochem. Sci., 9, pp. 207-208
  • Coirini, Weisenberg, Tornello, De Nicola, (1980) Experientia, 36, pp. 683-684
  • Cramer, Parker, Porter, (1979) Endocrinology, 104, pp. 419-422
  • De Hertogh, Ekka, Vanderheyden, (1982) Endocrinology, 110, pp. 741-748
  • De Hertogh, Vanderheyden, Delait, Ekka, (1984) J. Steroid Biochem., 21, pp. 433-437
  • Dufy, Vincent, Fleury, Du Pasquier, Gourdji, Tixier-Vidal, (1979) Nature (London), 282, pp. 855-857
  • Ekka, Vanderheyden, De Hertogh, (1982) Endocrinology, 111, pp. 456-461
  • Flückiger, del Pozo, von Werder, Control of Proclactin Secretion (1982) Monogr. Endocrinol., 23, pp. 24-64
  • Gala, Clarke, Haisenleder, Pan, Pieper, (1984) Endocrinology, 115, pp. 1256-1261
  • Gentry, Wade, Blaustein, (1977) Brain Res., 135, pp. 135-146
  • Gershengorn, Marcus-Samuels, Geras, (1979) Endocrinology, 105, pp. 171-176
  • Jensen, Suzuki, Kawashima, Stumpf, Jungblut, DeSombre, (1968) Proc. Natl. Acad. Sci. U.S.A., 59, pp. 632-638
  • Johnston, Tesone, Negro-Vilar, (1984) Life Sci., 34, pp. 1287-1297
  • Kirchick, Keyes, Frye, (1978) Endocrinology, 102, pp. 1867-1873
  • Li, (1964) Introduction to Experimental Statistics, pp. 454-465. , McGraw Hill, New York
  • Maurer, (1982) J. Biol. Chem., 257, pp. 2133-2136
  • Rossi, Bestetti, (1981) Diabetologia, 21, pp. 476-481
  • Roy, McEwen, (1977) Steroids, 30, pp. 657-669
  • Tesone, Landenheim, Oliveira Filho, Chiauzzi, Foglia, Charreau, (1983) Proc. Soc. Exp. Biol. Med., 174, pp. 123-130
  • Tesone, Ladenheim, Chiauzzi, Charreau, (1984) Mol. Cell. Endocrinol., 36, pp. 187-194
  • Tesone, Ladenheim, Cheb-Terrab, Chiauzzi, Solano, Podestá, Charreau, (1985) Endocrinology, , (submitted for publication)
  • Weisenberg, Fridman, Libertum, De Nicola, (1983) J. Steroid Biochem., 19, pp. 1737-1741

Citas:

---------- APA ----------
Tesone, M., Ladenheim, R.G. & Charreau, E.H. (1985) . Alterations in the prolactin secretion in streptozotocin-induced diabetic rats. Correlation with pituitary and hypothalamus estradiol receptors. Molecular and Cellular Endocrinology, 43(2-3), 135-140.
http://dx.doi.org/10.1016/0303-7207(85)90076-0
---------- CHICAGO ----------
Tesone, M., Ladenheim, R.G., Charreau, E.H. "Alterations in the prolactin secretion in streptozotocin-induced diabetic rats. Correlation with pituitary and hypothalamus estradiol receptors" . Molecular and Cellular Endocrinology 43, no. 2-3 (1985) : 135-140.
http://dx.doi.org/10.1016/0303-7207(85)90076-0
---------- MLA ----------
Tesone, M., Ladenheim, R.G., Charreau, E.H. "Alterations in the prolactin secretion in streptozotocin-induced diabetic rats. Correlation with pituitary and hypothalamus estradiol receptors" . Molecular and Cellular Endocrinology, vol. 43, no. 2-3, 1985, pp. 135-140.
http://dx.doi.org/10.1016/0303-7207(85)90076-0
---------- VANCOUVER ----------
Tesone, M., Ladenheim, R.G., Charreau, E.H. Alterations in the prolactin secretion in streptozotocin-induced diabetic rats. Correlation with pituitary and hypothalamus estradiol receptors. Mol. Cell. Endocrinol. 1985;43(2-3):135-140.
http://dx.doi.org/10.1016/0303-7207(85)90076-0