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Abstract:

Alterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased in follicular fluid of PCOS patients and in the ovaries of a rat model of PCOS. In the present study, we aimed to analyze the effects of local administration of PDGFB on ovarian angiogenesis, follicular development and ovulation in a DHEA-induced PCOS rat model. Ovarian PDGFB administration to PCOS rats partially restored follicular development, decreased the percentage of cysts, increased the percentage of corpora lutea, and decreased the production of anti-Müllerian hormone. In addition, PDGFB administration improved ovarian angiogenesis by reversing the increase in periendothelial cell area and restoring VEGF levels. Our results shed light into the mechanisms that lead to altered ovarian function in PCOS and provide new data for potential therapeutic strategies. © 2016 Elsevier Ireland Ltd.

Registro:

Documento: Artículo
Título:Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
Autor:Di Pietro, M.; Scotti, L.; Irusta, G.; Tesone, M.; Parborell, F.; Abramovich, D.
Filiación:Instituto de Biología y Medicina Experimental (IByME-CONICET), Vuelta de Obligado 2490, Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:Angiogenesis; Ovary; Platelet derived growth factor; Polycystic ovary syndrome; Muellerian inhibiting factor; prasterone; recombinant platelet derived growth factor; recombinant platelet derived growth factor B; unclassified drug; vasculotropin; Muellerian inhibiting factor; platelet derived growth factor B; vasculotropin A; animal cell; animal experiment; animal model; animal tissue; Article; controlled study; corpus luteum; drug efficacy; drug mechanism; endothelium cell; female; hormone synthesis; nonhuman; ovary cyst; ovary development; ovary follicle development; ovary polycystic disease; ovulation; periendothelium cell; priority journal; rat; animal; drug effects; metabolism; Neovascularization, Pathologic; Ovarian Hyperstimulation Syndrome; ovary follicle; ovary follicle fluid; ovulation; Polycystic Ovary Syndrome; Sprague Dawley rat; Animals; Anti-Mullerian Hormone; Female; Follicular Fluid; Neovascularization, Pathologic; Ovarian Follicle; Ovarian Hyperstimulation Syndrome; Ovulation; Polycystic Ovary Syndrome; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A
Año:2016
Volumen:433
Página de inicio:47
Página de fin:55
DOI: http://dx.doi.org/10.1016/j.mce.2016.05.022
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
ISSN:03037207
CODEN:MCEND
CAS:Muellerian inhibiting factor, 80497-65-0; prasterone, 53-43-0; vasculotropin, 127464-60-2; vasculotropin A, 489395-96-2; Anti-Mullerian Hormone; Proto-Oncogene Proteins c-sis; Vascular Endothelial Growth Factor A
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v433_n_p47_DiPietro

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Citas:

---------- APA ----------
Di Pietro, M., Scotti, L., Irusta, G., Tesone, M., Parborell, F. & Abramovich, D. (2016) . Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome. Molecular and Cellular Endocrinology, 433, 47-55.
http://dx.doi.org/10.1016/j.mce.2016.05.022
---------- CHICAGO ----------
Di Pietro, M., Scotti, L., Irusta, G., Tesone, M., Parborell, F., Abramovich, D. "Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome" . Molecular and Cellular Endocrinology 433 (2016) : 47-55.
http://dx.doi.org/10.1016/j.mce.2016.05.022
---------- MLA ----------
Di Pietro, M., Scotti, L., Irusta, G., Tesone, M., Parborell, F., Abramovich, D. "Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome" . Molecular and Cellular Endocrinology, vol. 433, 2016, pp. 47-55.
http://dx.doi.org/10.1016/j.mce.2016.05.022
---------- VANCOUVER ----------
Di Pietro, M., Scotti, L., Irusta, G., Tesone, M., Parborell, F., Abramovich, D. Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome. Mol. Cell. Endocrinol. 2016;433:47-55.
http://dx.doi.org/10.1016/j.mce.2016.05.022