Abstract:
Ovarian hyperstimulation syndrome (OHSS) is a disorder associated with ovarian stimulation. OHSS features are ovarian enlargement with fluid shifting to the third space. Disturbances in the vasculature are considered the main changes that lead to OHSS. Our aim was to analyze the levels of angiopoietins 1 and 2 (ANGPT1 and 2) and their soluble and membrane receptors (s/mTie-2) in follicular fluid (FF) and in granulosa-lutein cells culture (GLCs) from women at risk of developing OHSS. We also evaluated the effect of ANGPT1 on endothelial cell migration. In ovaries from an OHSS rat model, we analyzed the protein concentration of ANGPTs, their mTie-2 receptor, and platelet-derived growth factor PDGF-B, -D and PDGFR-β. ANGPT1 levels were increased in both FF and GLCs from women at risk of OHSS. Incubation of these FF with an ANGPT1 neutralizing antibody decreased endothelial cell migration. In the ovaries of OHSS rat model, mTie-2 protein levels increased and PDGF-B and -D decreased. In summary, these results suggest that ANGPT1 could be another mediator in the development of OHSS. © 2012 Elsevier Ireland Ltd.
Registro:
Documento: |
Artículo
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Título: | Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS) |
Autor: | Scotti, L.; Abramovich, D.; Pascuali, N.; de Zúñiga, I.; Oubiña, A.; Kopcow, L.; Lange, S.; Owen, G.; Tesone, M.; Parborell, F. |
Filiación: | Instituto de Biología y Medicina Experimental (IByME) - CONICET, Buenos Aires, Argentina Departamento de Química Biológica, Facultad de Ciencias Exactas, Universidad de Buenos Aires, Buenos Aires, Argentina Centro Médico PREGNA Medicina Reproductiva, Buenos Aires, Argentina Unidad de Reproducción y Desarrollo, Pontificia Universidad Católica de Chile, Santiago, Chile
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Palabras clave: | Angiogenesis; Angiopoietins; OHSS; Ovary; angiopoietin 1; angiopoietin 2; angiopoietin receptor; chorionic gonadotropin; neutralizing antibody; platelet derived growth factor B; platelet derived growth factor beta receptor; platelet derived growth factor D; adult; animal experiment; animal tissue; article; cell migration; controlled study; endothelium cell; female; granulosa cell; human; human cell; luteal cell; major clinical study; nonhuman; ovary follicle fluid; ovary hyperstimulation; priority journal; protein function; rat; risk factor; Adult; Angiopoietin-1; Angiopoietin-2; Animals; Antibodies; Case-Control Studies; Cell Movement; Cells, Cultured; Female; Follicular Fluid; Humans; Luteal Cells; Ovarian Hyperstimulation Syndrome; Ovary; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Receptor, TIE-2 |
Año: | 2013
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Volumen: | 365
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Número: | 2
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Página de inicio: | 223
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Página de fin: | 230
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DOI: |
http://dx.doi.org/10.1016/j.mce.2012.10.022 |
Título revista: | Molecular and Cellular Endocrinology
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Título revista abreviado: | Mol. Cell. Endocrinol.
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ISSN: | 03037207
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CODEN: | MCEND
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CAS: | angiopoietin 1, 186270-49-5; angiopoietin 2, 194368-66-6; chorionic gonadotropin, 9002-61-3; ANGPT1 protein, human; Angiopoietin-1; Angiopoietin-2; Antibodies; Proto-Oncogene Proteins c-sis; Receptor, Platelet-Derived Growth Factor beta, 2.7.10.1; Receptor, TIE-2, 2.7.10.1
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v365_n2_p223_Scotti |
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Citas:
---------- APA ----------
Scotti, L., Abramovich, D., Pascuali, N., de Zúñiga, I., Oubiña, A., Kopcow, L., Lange, S.,..., Parborell, F.
(2013)
. Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS). Molecular and Cellular Endocrinology, 365(2), 223-230.
http://dx.doi.org/10.1016/j.mce.2012.10.022---------- CHICAGO ----------
Scotti, L., Abramovich, D., Pascuali, N., de Zúñiga, I., Oubiña, A., Kopcow, L., et al.
"Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)"
. Molecular and Cellular Endocrinology 365, no. 2
(2013) : 223-230.
http://dx.doi.org/10.1016/j.mce.2012.10.022---------- MLA ----------
Scotti, L., Abramovich, D., Pascuali, N., de Zúñiga, I., Oubiña, A., Kopcow, L., et al.
"Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)"
. Molecular and Cellular Endocrinology, vol. 365, no. 2, 2013, pp. 223-230.
http://dx.doi.org/10.1016/j.mce.2012.10.022---------- VANCOUVER ----------
Scotti, L., Abramovich, D., Pascuali, N., de Zúñiga, I., Oubiña, A., Kopcow, L., et al. Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS). Mol. Cell. Endocrinol. 2013;365(2):223-230.
http://dx.doi.org/10.1016/j.mce.2012.10.022