Artículo

Larocca, L.; Hauk, V.; Calafat, M.; Roca, V.; Fraccaroli, L.; Franchi, A.; Ramhorst, R.; Leirós, C.P. "Modulation of macrophage inflammatory profile in pregnant nonobese diabetic (NOD) mice" (2011) Molecular and Cellular Endocrinology. 333(2):112-118
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Abstract:

During normal early pregnancy circulating monocytes are recruited to the maternal-placental interface where they differentiate to macrophages expressing different functional phenotypes for the maintenance of tissue homeostasis. Pregnancy in the nonobese diabetic (NOD) mouse model presents some pathological features in the pre-diabetic stage. The aim of this work was to analyze the functional profile of peritoneal macrophages faced with inflammatory and phagocytic stimuli in early pregnant pre-diabetic NOD mice and their modulation by vasoactive intestinal peptide (VIP). Pregnant NOD mouse macrophages showed no basal NFκB activation, lower IL-12 and nitrites production compared with the macrophages from non-pregnant NOD mice. Their pro-inflammatory aberrant response to LPS and apoptotic cell challenge was reduced and VIP inhibited macrophage residual deleterious responses to apoptotic cells. A functional phenotype switch in macrophages during pregnancy in NOD mice and a promoting effect of VIP towards this regulatory phenotype would be in line with the central role of macrophages in the maternal-placental dialogue. © 2010 Elsevier Ireland Ltd.

Registro:

Documento: Artículo
Título:Modulation of macrophage inflammatory profile in pregnant nonobese diabetic (NOD) mice
Autor:Larocca, L.; Hauk, V.; Calafat, M.; Roca, V.; Fraccaroli, L.; Franchi, A.; Ramhorst, R.; Leirós, C.P.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina
CEFYBO, Facultad de Medicina, UBA - CONICET, Buenos Aires, Argentina
Palabras clave:Macrophage phenotypes; NOD mice; Phagocytosis; Pregnancy; VIP; gamma interferon; immunoglobulin enhancer binding protein; interleukin 10; interleukin 12; synaptotagmin I; vasoactive intestinal polypeptide; animal cell; animal experiment; apoptosis; article; cell stimulation; cellular distribution; controlled study; cytokine response; female; first trimester pregnancy; mouse; nonhuman; peritoneum macrophage; phagocyte; phagocytosis; phenotype; pregnancy; priority journal; protein expression; protein function; Animals; Apoptosis; Coculture Techniques; Female; Inflammation; Kinetics; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; NF-kappa B; Phagocytosis; Pregnancy
Año:2011
Volumen:333
Número:2
Página de inicio:112
Página de fin:118
DOI: http://dx.doi.org/10.1016/j.mce.2010.11.035
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
ISSN:03037207
CODEN:MCEND
CAS:gamma interferon, 82115-62-6; interleukin 12, 138415-13-1; vasoactive intestinal polypeptide, 37221-79-7; Lipopolysaccharides; NF-kappa B
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v333_n2_p112_Larocca

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Citas:

---------- APA ----------
Larocca, L., Hauk, V., Calafat, M., Roca, V., Fraccaroli, L., Franchi, A., Ramhorst, R.,..., Leirós, C.P. (2011) . Modulation of macrophage inflammatory profile in pregnant nonobese diabetic (NOD) mice. Molecular and Cellular Endocrinology, 333(2), 112-118.
http://dx.doi.org/10.1016/j.mce.2010.11.035
---------- CHICAGO ----------
Larocca, L., Hauk, V., Calafat, M., Roca, V., Fraccaroli, L., Franchi, A., et al. "Modulation of macrophage inflammatory profile in pregnant nonobese diabetic (NOD) mice" . Molecular and Cellular Endocrinology 333, no. 2 (2011) : 112-118.
http://dx.doi.org/10.1016/j.mce.2010.11.035
---------- MLA ----------
Larocca, L., Hauk, V., Calafat, M., Roca, V., Fraccaroli, L., Franchi, A., et al. "Modulation of macrophage inflammatory profile in pregnant nonobese diabetic (NOD) mice" . Molecular and Cellular Endocrinology, vol. 333, no. 2, 2011, pp. 112-118.
http://dx.doi.org/10.1016/j.mce.2010.11.035
---------- VANCOUVER ----------
Larocca, L., Hauk, V., Calafat, M., Roca, V., Fraccaroli, L., Franchi, A., et al. Modulation of macrophage inflammatory profile in pregnant nonobese diabetic (NOD) mice. Mol. Cell. Endocrinol. 2011;333(2):112-118.
http://dx.doi.org/10.1016/j.mce.2010.11.035