Artículo

Labeur, M.; Páez-Pereda, M.; Haedo, M.; Arzt, E.; Stalla, G.K. "Pituitary tumors: Cell type-specific roles for BMP-4" (2010) Molecular and Cellular Endocrinology. 326(1-2):85-88
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Abstract:

BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid. © 2010 Elsevier Ireland Ltd.

Registro:

Documento: Artículo
Título:Pituitary tumors: Cell type-specific roles for BMP-4
Autor:Labeur, M.; Páez-Pereda, M.; Haedo, M.; Arzt, E.; Stalla, G.K.
Filiación:Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804 Munich, Germany
Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, FCEN, Universidad de Buenos Aires and CONICET, C1428EHA Buenos Aires, Argentina
Palabras clave:ACTH; BMP-4; Pituitary tumors; Prolactin; Retinoic acid; TGF-β; bone morphogenetic protein 4; bromocriptine; corticotropin; cyclic AMP; estradiol; estrogen; growth hormone releasing factor; messenger RNA; octreotide; pasireotide; prolactin; recombinant follitropin; Smad protein; somatostatin derivative; ACTH secreting cell; article; carcinogenesis; cell proliferation; cell type; Cushing disease; disease association; drug mechanism; drug potentiation; genetic transcription; gonadotropin secreting cell; growth hormone secreting adenoma; hormone release; human; hypophysis adenoma; hypophysis tumor; nonhuman; priority journal; prolactin secreting cell; prolactinoma; signal transduction; Adrenocorticotropic Hormone; Adult; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Humans; Mice; Pituitary ACTH Hypersecretion; Pituitary Gland; Pituitary Neoplasms; Prolactin; Prolactinoma; Rats
Año:2010
Volumen:326
Número:1-2
Página de inicio:85
Página de fin:88
DOI: http://dx.doi.org/10.1016/j.mce.2010.04.006
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
ISSN:03037207
CODEN:MCEND
CAS:Smad protein, 62395-38-4; bromocriptine, 25614-03-3; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; cyclic AMP, 60-92-4; estradiol, 50-28-2; growth hormone releasing factor, 83930-13-6, 9034-39-3; octreotide, 83150-76-9; pasireotide, 396091-73-9; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; Adrenocorticotropic Hormone, 9002-60-2; BMP4 protein, human; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Prolactin, 9002-62-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v326_n1-2_p85_Labeur

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Citas:

---------- APA ----------
Labeur, M., Páez-Pereda, M., Haedo, M., Arzt, E. & Stalla, G.K. (2010) . Pituitary tumors: Cell type-specific roles for BMP-4. Molecular and Cellular Endocrinology, 326(1-2), 85-88.
http://dx.doi.org/10.1016/j.mce.2010.04.006
---------- CHICAGO ----------
Labeur, M., Páez-Pereda, M., Haedo, M., Arzt, E., Stalla, G.K. "Pituitary tumors: Cell type-specific roles for BMP-4" . Molecular and Cellular Endocrinology 326, no. 1-2 (2010) : 85-88.
http://dx.doi.org/10.1016/j.mce.2010.04.006
---------- MLA ----------
Labeur, M., Páez-Pereda, M., Haedo, M., Arzt, E., Stalla, G.K. "Pituitary tumors: Cell type-specific roles for BMP-4" . Molecular and Cellular Endocrinology, vol. 326, no. 1-2, 2010, pp. 85-88.
http://dx.doi.org/10.1016/j.mce.2010.04.006
---------- VANCOUVER ----------
Labeur, M., Páez-Pereda, M., Haedo, M., Arzt, E., Stalla, G.K. Pituitary tumors: Cell type-specific roles for BMP-4. Mol. Cell. Endocrinol. 2010;326(1-2):85-88.
http://dx.doi.org/10.1016/j.mce.2010.04.006