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Abstract:

The aims of this study were to investigate the effects of chronic feed deprivation on the ovulatory process, and to assess whether leptin administration is able to alter these effects. Prepuberal rats subjected to food restriction and primed with gonadotrophins were used. Body and ovarian weights were significantly decreased in proportion to the severity of the food restriction. Only the most severe feed deprivation was able to inhibit the ovulation rate. Either buffer or leptin was daily administrated to prepuberal rats fed either ad libitum or with a severe food restriction. Serum progesterone, ovulation rate and ovarian prostaglandin E2 were reduced in rats subjected to food restriction and stimulated by daily administration of leptin in rats fed ad libitum. Negative effects produced by a severe food restriction were partially reversed by chronic administration of leptin. The ovarian endothelium nitric oxide synthase expression was strongly inhibited in rats with food restriction and once again, leptin administration reversed this effect. In summary, the ovulatory process was significantly inhibited in response to a severe decrease in food intake, at least in part, to the direct or indirect impairment of some ovarian factors production as prostaglandins and nitric oxide. Chronic treatment with leptin enhanced the ovulatory process in comparison with control animals, and partially prevented these negative effects produced by a severe malnutrition. © 2005 Elsevier Ireland Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Leptin enhances ovulation and attenuates the effects produced by food restriction
Autor:Roman, E.A.; Ricci, A.G.; Faletti, A.G.
Filiación:Dpto. de Química Biológica, Facultad de Ciencias Exactas Y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
Centro de Estudios Farmacológicos Y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas Y Técnicas (CONICET), C1414DEM, Serrano 669, Buenos Aires, Argentina
Palabras clave:Food restriction; Leptin; Nitric oxide (rat ovary); Ovulation; Prostaglandins; gonadotropin; leptin; nitric oxide; nitric oxide synthase; progesterone; prostaglandin E2; animal tissue; article; body weight; controlled study; diet restriction; enzyme activity; enzyme inhibition; female; food deprivation; food intake; hormone action; inhibition kinetics; nonhuman; ovary; ovulation; prepuberty; priority journal; progesterone blood level; protein expression; rat; tissue level; Animals; Dinoprostone; Female; Food Deprivation; Leptin; Nitric Oxide Synthase Type III; Organ Size; Ovulation; Rats; Rats, Sprague-Dawley
Año:2005
Volumen:242
Número:1-2
Página de inicio:33
Página de fin:41
DOI: http://dx.doi.org/10.1016/j.mce.2005.07.007
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
ISSN:03037207
CODEN:MCEND
CAS:gonadotropin, 63231-54-9; nitric oxide synthase, 125978-95-2; nitric oxide, 10102-43-9; progesterone, 57-83-0; prostaglandin E2, 363-24-6; Dinoprostone, 363-24-6; Leptin; Nitric Oxide Synthase Type III, EC 1.14.13.39
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v242_n1-2_p33_Roman

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Citas:

---------- APA ----------
Roman, E.A., Ricci, A.G. & Faletti, A.G. (2005) . Leptin enhances ovulation and attenuates the effects produced by food restriction. Molecular and Cellular Endocrinology, 242(1-2), 33-41.
http://dx.doi.org/10.1016/j.mce.2005.07.007
---------- CHICAGO ----------
Roman, E.A., Ricci, A.G., Faletti, A.G. "Leptin enhances ovulation and attenuates the effects produced by food restriction" . Molecular and Cellular Endocrinology 242, no. 1-2 (2005) : 33-41.
http://dx.doi.org/10.1016/j.mce.2005.07.007
---------- MLA ----------
Roman, E.A., Ricci, A.G., Faletti, A.G. "Leptin enhances ovulation and attenuates the effects produced by food restriction" . Molecular and Cellular Endocrinology, vol. 242, no. 1-2, 2005, pp. 33-41.
http://dx.doi.org/10.1016/j.mce.2005.07.007
---------- VANCOUVER ----------
Roman, E.A., Ricci, A.G., Faletti, A.G. Leptin enhances ovulation and attenuates the effects produced by food restriction. Mol. Cell. Endocrinol. 2005;242(1-2):33-41.
http://dx.doi.org/10.1016/j.mce.2005.07.007