Artículo

Carbia Nagashima, A.C.; Giacomini, D.; Perez Castro, C.; Paez Pereda, M.; Renner, U.; Stalla, G.K.; Arzt, E. "Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells" (2003) Molecular and Cellular Endocrinology. 201(1-2):47-56
La versión final de este artículo es de uso interno. El editor solo permite incluir en el repositorio el artículo en su versión post-print. Por favor, si usted la posee enviela a
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Interleukin-6 (IL-6) secreted by pituitary folliculo stellate (FS) cells plays an important role in the control of pituitary function and proliferation. We demonstrate that in FS TtT/GF cells, estradiol (E2) inhibits dose dependently pituitary adenylate cyclase activating polypeptide (PACAP)-stimulated IL-6 secretion and transcription. We studied transcription factors involved in IL-6 stimulation by PACAP. Point mutations in κB, TRE, NF-IL-6 and CRE sites in the IL-6 promoter show that PACAP stimulates IL-6 through TRE and CRE sites. Accordingly, PACAP stimulated AP-1 and CREB transcriptional activity and E2 inhibited TRE-LUC but not CRE-LUC activation. Thus, we demonstrate that transcription factors of the CREB and AP-1 family are critical for the stimulation of IL-6 by PACAP in TtT/GF cells and that estrogens block this stimulation by inhibiting AP-1 activity. The regulatory elements involved in IL-6 transcription in TtT/GF FS cells contribute to understand the specificity of the anterior pituitary gland paracrine pathways. © 2003 Elsevier Science Ireland Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells
Autor:Carbia Nagashima, A.C.; Giacomini, D.; Perez Castro, C.; Paez Pereda, M.; Renner, U.; Stalla, G.K.; Arzt, E.
Filiación:Depto. Fisiol. y Biol. Molec. y Cel., Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
Department of Endocrinology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
Palabras clave:AP-1; CREB; Estrogens; Folliculo-stellate cells; IL-6; PACAP; estradiol; hypophysis adenylate cyclase activating polypeptide; interleukin 6; transcription factor; transcription factor AP 1; transcription factor CREB; transcription factor TRE; unclassified drug; animal cell; article; cell proliferation; concentration response; controlled study; cytokine release; hypophysis function; mouse; nonhuman; point mutation; priority journal; stellate cell; transcription initiation site; transcription regulation
Año:2003
Volumen:201
Número:1-2
Página de inicio:47
Página de fin:56
DOI: http://dx.doi.org/10.1016/S0303-7207(02)00435-5
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
ISSN:03037207
CODEN:MCEND
CAS:estradiol, 50-28-2; hypophysis adenylate cyclase activating polypeptide, 137061-48-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v201_n1-2_p47_CarbiaNagashima

Referencias:

  • Angel, P., Imagawa, M., Chiu, R., Stein, B., Imbra, R.J., Rahmsdorf, H.J., Jonat, C., Karin, M., Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor (1987) Cell, 49, pp. 729-739
  • Arzt, E., Buric, R., Stelzer, G., Stalla, J., Sauer, J., Renner, U., Stalla, G.K., Interleukin involvement in anterior pituitary cell growth regulation: Effects of interleukin-2 (IL-2) and IL-6 (1993) Endocrinology, 132, pp. 459-467
  • Arzt, E., Paez Pereda, M., Perez Castro, C., Pagotto, U., Renner, U., Stalla, G.K., Pathophysiological role of the cytokine network in the anterior pituitary gland (1999) Front Neuroendocrinol., 20, pp. 71-95
  • Asa, S.L., Kelly, M.A., Grandy, D.K., Low, M.J., Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice (1999) Endocrinology, 140, pp. 5348-5355
  • Berthois, Y., Katzenellenbogen, J.A., Katzenellenbogen, B.S., Phenol red in tissue culture media is a weak estrogen: Implications concerning the study of estrogen-responsive cells in culture (1986) Proc. Natl. Acad. Sci. USA, 83, pp. 2496-2500
  • Chaidarun, S.S., Eggo, M.C., Stewart, P.M., Barber, P.C., Sheppard, M.C., Role of growth factors and estrogen as modulators of growth, differentiation and expression of gonadotropin subunit genes in primary cultured sheep pituitary cells (1994) Endocrinology, 134, pp. 935-944
  • De Groot, R.P., Sassone-Corsi, P., Activation of Jun/AP-1 by protein kinase A (1992) Oncogene, 7, pp. 2281-2286
  • Deshpande, R., Khalili, H., Pergolizzi, R.G., Michael, S., Chang, M.Y., Estradiol down-regulates LPS-induced cytokine production and NFkappaB activation in murine macrophages (1997) Am. J. Reprod. Immunol., 38, pp. 46-54
  • Eickelberg, O., Pansky, A., Mussmann, R., Bihl, K., Tamm, M., Hildebrand, P., Perruchoud, A.P., Roth, M., Transforming growth factor-beta1 induces Interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts (1999) J. Biol. Chem., 274, pp. 12933-12938
  • Franchimont, N., Durant, D., Rydziel, S., Canalis, E., Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2 (1999) J. Biol. Chem., 274, pp. 6783-6789
  • Friend, K.E., Chio, Y.K., Lopes, M.B., Laws, E.R., Hughes, K.M., Shupnik, M.A., Estrogen receptor expression in human pituitary: Correlation with immunohistochemistry in normal tissue, and immunohistochemistry and morphology in macroadenomas (1994) J. Clin. Endocrinol. Metab., 78, pp. 1497-1504
  • Galien, R., Garcia, T., Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kappaB site (1997) Nucl. Acids Res., 25, pp. 2424-2429
  • Galien, R., Evans, H.F., Garcia, T., Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding sites in interleukin-6 inhibition by estrogens (1996) Mol. Endocrinol., 10, pp. 713-722
  • Garcia, M.M., Kapcala, L.P., Growth of a microprolactinoma to a macroprolactinoma during estrogen therapy (1995) J. Endocrinol. Invest., 18, pp. 450-455
  • Girasole, G., Jilka, R., Passeri, G., Boswell, S., Boder, G., Williams, D., Manolagas, S., 17-beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanism for the antiosteoporotic effect of estrogen (1992) J. Clin. Invest., 89, pp. 883-891
  • Heaney, A.P., Horwitz, G.A., Wang, Z., Singson, R., Melmed, S., Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis (1999) Nat. Med., 5, pp. 1317-1321
  • Inoue, K., Matsumoto, H., Koyama, C., Shibata, K., Nakazato, Y., Ito, A., Establishment of a folliculo-stellate cells line from a murine thyrotropic pituitary tumor (1992) Endocrinology, 131, pp. 3110-3116
  • Kalli, K., Huntoon, C., Bell, M., McKean, D.J., Mechanism responsible for T-cell antigen receptor- and CD28- or interleukin 1 (IL-1) receptor-initiated regulation of IL-2 gene expression by NF-kappaB (1998) Mol. Cell. Biol., 18, pp. 3140-3148
  • Kelly, M.A., Rubinstein, M., Asa, S.L., Zhang, G., Saez, C., Bunzow, J.R., Allen, R.G., Low, M.J., Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice (1997) Neuron, 19, pp. 103-113
  • Kobayashi, H., Fukata, J., Murakami, N., Usui, T., Ebisui, O., Muro, S., Hanaoka, I., Nakao, K., TNF receptors in pituitary cells (1997) Brain Res., 758, pp. 45-50
  • Koyama, C., Matsumoto, H., Sakai, T., Wakabayashi, K., Ito, A., Couch, E.F., Inoue, K., Pituitary folliculo-stellate-like cells stimulate somatotropic pituitary tumor growth in nude mice (1995) Endocrinol. Pathol., 6, pp. 67-75
  • Lee, W., Mitchell, P., Tjian, R., Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements (1987) Cell, 49, pp. 741-752
  • Lee, E.J., Duan, W.R., Jakacka, M., Gehm, B.D., Jameson, J.L., Dominant negative ER induces apoptosis in GH(4) pituitary lactotrope cells and inhibits tumor growth in nude mice (2001) Endocrinology, 142, pp. 3756-3763
  • Lieberman, M.E., Maurer, R.A., Claude, P., Wiklund, J., Wertz, N., Gorski, J., Regulation of pituitary growth and prolactin gene expression by estrogen (1981) Adv. Exp. Med. Biol., 138, pp. 151-163
  • Lohrer, P., Gloddek, J., Carbia Nagashima, A., Korali, Z., Hopfner, U., Paez Pereda, M., Arzt, E., Renner, U., Lipopolysacchride directly stimulates the intrapituitary Interleukin-6 production by folliculostellate cells via specific receptors and the p38alpha mitogen-activated protein kinase/nuclear factor-kappa B pathway (2000) Endocrinology, 141, pp. 4457-4465
  • Martinez-Fuentes, A., Castaño, J., Garcia-Navarro, F., Malagon, M., Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP27 activate common and distinct intracellular signaling pathways to stimulate growth hormones secretion from porcine somatotropes (1998) Endocrinology, 139, pp. 5116-5124
  • Matsumoto, H.C.K., Sawada, T., Koike, K., Hirota, K., Miyake, A., Arimura, A., Inoue, K., Pituitary folliculo-stellate-like cell line (TtT/GF) responds to novel hypophysiotrophic peptide (pituitary adenylate cyclase-activating peptide), showing increased adenosine 3′,5′-monophosphate and interleukin-6 secretion and cell proliferation (1993) Endocrinology, 133, pp. 2150-2155
  • Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., Akira, S., Transcription factors NF-IL6 and NF-kappaB synergistically activate transcription of the inflammatory cytokines, interleukin-6 and interleukin-8 (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 10193-10197
  • Mitchner, N.A., Garlick, C., Ben-Jonathan, N., Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat pituitary gland (1998) Endocrinology, 139, pp. 3976-3983
  • Morand, I., Fonlupt, P., Guerrier, A., Trouillas, J., Calle, A., Remy, C., Rousset, B., Munari-Silem, Y., Cell-to-cell communication in the anterior pituitary: Evidence for gap junction-mediated exchanges between endocrine cells and folliculo-stellate cells (1996) Endocrinology, 137, pp. 3356-3367
  • Mueller, S.O., Korach, K.S., Estrogen receptors and endocrine diseases: Lessons from estrogen receptor knockout mice (2001) Curr. Opin. Pharmacol., 1, pp. 613-619
  • Muller Igaz, L., Refojo, D., Costas, M.A., Holsboer, F., Arzt, E., CRE-mediated transcriptional activation is involved in cAMP protection of T-cell receptor-induced apoptosis but not in cAMP potentiation of glucocorticoid-mediated programmed cell death (2002) Biochim. Biophys. Acta, 1542, pp. 139-148
  • Nakajima, T., Yamaguchi, H., Takahashi, K., S-100 protein in follicullo-stellate cells of the rat pituitary anterior lobe (1980) Brain Res., 191, pp. 523-531
  • Newton, C.J., Arzt, E., Stalla, G.K., Involvement of the estrogen receptor in the growth response of pituitary tumor cells to interleukin-2 (1994) Biochem. Biophys. Res. Commun., 205, pp. 1930-1937
  • Nilsson, S., Makela, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Gustafsson, J.A., Mechanisms of estrogen action (2001) Physiol. Rev., 81, pp. 1535-1565
  • Paech, K., Webb, P., Kuiper, G., Nilsson, S., Gustafsson, J., Kushner, P., Scanlan, T., Differential ligand activation of estrogen receptors ER-alpha and ER-beta at AP1 sites (1997) Science, 277, pp. 1508-1510
  • Rawlings, S.R., Hezareh, M., Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP/vasoactive intestinal polypeptide receptors: Actions on the anterior pituitary gland (1996) Endocrinol. Rev., 17, pp. 4-28
  • Ray, P., Gosh, S.K., Zhang, D.H., Ray, A., Repression of interleukin-6 gene expression by 17beta-estradiol: Inhibition of the DNA binding activity of the transcription factors NF-IL6 and NF-kappaB by the estrogen receptor (1997) FEBS Lett., 409, pp. 79-85
  • Renner, U., Gloddek, J., Arzt, E., Inoue, K., Stalla, G.K., Interleukin-6 is an autocrine growth factor for folliculostellate-like TtT/GF mouse pituitary tumor cells (1997) Exp. Clin. Endocrinol. Diab., 105, pp. 345-352
  • Renner, U., Gloddek, J., Paez Pereda, M., Arzt, E., Stalla, G.K., Regulation and role of intrapituitary IL-6 production by folliculostellate cells (1998) Domest. Anim. Endocrinol., 15, pp. 353-362
  • Rinehart, J., Farquhar, M., Electrone microscopic studies of the anterior pituitary gland (1953) J. Histochem. Cytochem., 1, pp. 93-113
  • Sawada, T., Koike, K., Kanda, Y., Ikegami, H., Jikihara, H., Maeda, T., Osako, Y., Miyake, A., Interleukin-6 stimulates cell proliferation of rat pituitary clonal cell lines in vitro (1995) J. Endocrinol. Invest., 18, pp. 83-90
  • Shull, J.D., Gorski, J., Estrogen stimulates prolactin gene transcription by a mechanism independent of pituitary protein synthesis (1984) Endocrinology, 114, pp. 1550-1557
  • Spangelo, B.L., Judd, A.M., Isakson, P.C., MacLeod, R.M., Interleukin-6 stimulates anterior pituitary hormone release in vitro (1989) Endocrinology, 127, pp. 575-577
  • Spangelo, B.L., Judd, A.M., Isakson, P.C., MacLeod, R.M., Interleukin-1 stimulates interleukin-6 release from rat anterior pituitary cells in vitro (1991) Endocrinology, 128, pp. 2685-2692
  • Stefaneanu, L., Kovacs, K., Lloyd, R.V., Scheithauer, B.W., Young W.F., Jr., Sano, T., Jin, L., Pituitary lactotrophs and somatotrophs in pregnancy: A correlative in situ hybridization and immunocytochemical study (1992) Virchows Arch. B Cell. Pathol. Incl. Mol. Pathol., 62, pp. 291-296
  • Sudo, T., Sakuma, Y., Kato, M., Bradykinin and angiotensin II-induced [Ca2+]i rise in cultured rat pituitary folliculo-stellate cells (2001) J. Neuroendocrinol., 13, pp. 942-950
  • Sun, P., Lou, L., Maurer, R.A., Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV (1996) J. Biol. Chem., 271, pp. 3066-3073
  • Tatsuno, I., Somogyvari-Vigh, A., Mizuno, K.P.G., Hidaka, H., Arimura, A., Neuropeptide regulation of interleukin-6 production from pituitary: Stimulation by pituitary adenylate cyclase-activating polypeptide and calcitonin gene-related peptide (1991) Endocrinology, 129, pp. 1797-1804
  • Turquier, V., Yon, L., Grumolato, L., Alexandre, D., Fournier, A., Vaudry, H., Anouar, Y., Pituitary adenylate cyclase-activating polypeptide stimulates secretoneurin release and secretogranin II gene transcription in bovine adrenochromaffin cells through multiple signaling pathways and increased binding of pre-existing activator protein-1-like transcription factors (2001) Mol. Pharmacol., 60, pp. 42-52
  • Vanden Berghe, W., Plaisance, S., Boone, E., De Bosscher, K., Lienhard Schmitz, M., Fiers, W., Haegeman, G., P38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappa B p65 transactivation mediated by tumor necrosis factor (1998) J. Biol. Chem., 273, pp. 3285-3290
  • Vankelecom, H., Matthys, P., Van Damme, J., Heremans, H., Billiau, A., Denef, C., Immunocytochemical evidence that S-100 positive cells of the mouse anterior pituitary contain interleukin-6 immunoreactivity (1993) J. Histochem. Cytochem., 41, pp. 151-156
  • Velasco, M.E., Roessmann, U., Gambetti, P., The presence of glial fibrillary acidic protein in the human pituitary gland (1982) J. Neuropathol. Exp. Neurol., 41, pp. 150-163
  • Weatherman, R., Scanlan, T., Unique protein determinants of the subtype-selective ligand responses of the estrogen receptors (ER-alpha and ER-beta) at AP-1 sites (2001) J. Biol. Chem., 6, pp. 3827-3832
  • Williams, C., Baer, M., Dillner, A., Johnson, P., CRP2 (c/EBPbeta) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity (1995) EMBO J., 14, pp. 3170-3183
  • Yada, T., Vigh, S., Arimura, A., Pituitary adenylate cyclase activating polypeptide (PACAP) increases cytosolic-free-calcium concentration in folliculo-stellate cells and somatotropes of rat pituitary (1993) Peptides, 14, pp. 235-239

Citas:

---------- APA ----------
Carbia Nagashima, A.C., Giacomini, D., Perez Castro, C., Paez Pereda, M., Renner, U., Stalla, G.K. & Arzt, E. (2003) . Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells. Molecular and Cellular Endocrinology, 201(1-2), 47-56.
http://dx.doi.org/10.1016/S0303-7207(02)00435-5
---------- CHICAGO ----------
Carbia Nagashima, A.C., Giacomini, D., Perez Castro, C., Paez Pereda, M., Renner, U., Stalla, G.K., et al. "Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells" . Molecular and Cellular Endocrinology 201, no. 1-2 (2003) : 47-56.
http://dx.doi.org/10.1016/S0303-7207(02)00435-5
---------- MLA ----------
Carbia Nagashima, A.C., Giacomini, D., Perez Castro, C., Paez Pereda, M., Renner, U., Stalla, G.K., et al. "Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells" . Molecular and Cellular Endocrinology, vol. 201, no. 1-2, 2003, pp. 47-56.
http://dx.doi.org/10.1016/S0303-7207(02)00435-5
---------- VANCOUVER ----------
Carbia Nagashima, A.C., Giacomini, D., Perez Castro, C., Paez Pereda, M., Renner, U., Stalla, G.K., et al. Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells. Mol. Cell. Endocrinol. 2003;201(1-2):47-56.
http://dx.doi.org/10.1016/S0303-7207(02)00435-5