Artículo

Duvilanski, B.H.; Velardez, M.O.; Gonzalez Iglesias, A.; Theas, S.; Seilicovich, A.; Becu-Villalobos, D. "Nitric oxide donors modify free intracellular calcium levels in rat anterior pituitary cells" (1998) Molecular and Cellular Endocrinology. 146(1-2):19-26
El editor solo permite decargar el artículo en su versión post-print desde el repositorio. Por favor, si usted posee dicha versión, enviela a
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The effect of nitric oxide donors on intracellular calcium concentration [Ca2+](i) was studied in anterior pituitary cells using ratiometric FURA 2 fluorescence measurements. Sodium nitroprusside (NP) induced a transient decrease [Ca2+](i), after which [Ca2+](i) returned to, or even increased over basal values. S-Nitroso glutathione (GSNO) induced a similar decrease. NP also inhibited high [Ca2+)(i) achieved by depolarization with 25 mM K+. The inhibitory effect of NP was partially blunted by pretreatment with methoxy-verapamil, and in calcium free buffer, and was not altered by thapsigargin. Interestingly, in calcium free buffer there was a significant stimulatory effect of NP, which was partially blunted by thapsigargin. We conclude that NO donors modify [Ca2+](i) in anterior pituitary cells. The action is biphasic, with an initial decrease in [Ca2+](i) probably related to a decrease of Ca2+ influx through VDCC, and an increase evidenced in calcium free buffer in which the inhibitory component is absent, and partially depends on thapsigargin sensitive calcium stores.

Registro:

Documento: Artículo
Título:Nitric oxide donors modify free intracellular calcium levels in rat anterior pituitary cells
Autor:Duvilanski, B.H.; Velardez, M.O.; Gonzalez Iglesias, A.; Theas, S.; Seilicovich, A.; Becu-Villalobos, D.
Filiación:Ctro. de Invest. en Reprod., Facultad de Medicina, Universidad de Buenos Aires, Piso 10, 1121 Buenos Aires, Argentina
Inst. de Biol. y Med. Experimental, CONICET, V. Obligado 2490, Buenos Aires 1428, Argentina
Palabras clave:Calcium channels; Nitric oxide; Pituitary; calcium ion; gallopamil; nitric oxide donor; nitroprusside sodium; s nitrosoglutathione; adenohypophysis; animal cell; article; calcium cell level; calcium mobilization; cell membrane depolarization; controlled study; hypophysis cell; male; nonhuman; priority journal; rat; signal transduction; Animals; Buffers; Calcium; Calcium Channel Blockers; Gallopamil; Glutathione; Intracellular Fluid; Kinetics; Male; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Pituitary Gland, Anterior; Potassium; Rats; Rats, Wistar; S-Nitrosoglutathione; Thapsigargin
Año:1998
Volumen:146
Número:1-2
Página de inicio:19
Página de fin:26
DOI: http://dx.doi.org/10.1016/S0303-7207(98)00203-2
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
ISSN:03037207
CODEN:MCEND
CAS:Buffers; Calcium Channel Blockers; Calcium, 7440-70-2; Gallopamil, 16662-47-8; Glutathione, 70-18-8; Nitric Oxide Donors; Nitroprusside, 15078-28-1; Nitroso Compounds; Potassium, 7440-09-7; S-Nitrosoglutathione, 57564-91-7; Thapsigargin, 67526-95-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v146_n1-2_p19_Duvilanski

Referencias:

  • Brunetti, L., Preziosi, P., Ragazzoni, E., Vacca, M., Involvement of nitric oxide in basal and interleukin-1-beta-induced CRH and ACTH release in vitro (1993) Life Sci., 53, pp. 219-222
  • Burgoyne, R.D., Morgan, A., Regulated exocytosis (1993) Biochem. J., 293, pp. 305-316
  • Chen, C., Clarke, I.J., Effects of growth hormone-releasing peptide-2 (GHRP-2) on membrane Ca2+ permeability in cultured ovine somatotrophs (1995) J. Neuroendocrinol., 7, pp. 179-186
  • Chik, C.L., Liu, Q.Y., Li, B., Karpinski, E., Ho, A.K., CGMP inhibits L-type Ca2+ channel currents through protein phosphorilation in rat pinealocytes (1995) J. Neurosci., 15, pp. 3104-3109
  • Cuttica, C.M., Giusti, M., Bocca, L., Sessarego, P., De Martini, D., Valenti, S., Spaziante, R., Giordano, G., Nitric oxide modulates in vivo and in vitro growth homone release in acromegaly (1997) Neuroendocrinology, 66, pp. 426-431
  • Diaz-Torga, G.S., Gonzalez Iglesias, A., Achaval-Zaia, R., Libertun, C., Becu-Villalobos, D., Angiotensin II induced Ca2+ mobilization and prolactin release in normal and estrogen treated pituitary cells (1998) Am. J. Physiol., 274, pp. 534-E540
  • Duvilanski, B.H., Zambruno, C., Seilicovich, A., Pisera, D., Lasaga, M., Díaz, M.C., Belova, N., Mc Cann, S.M., The role of nitric oxide in control of prolactin release by the adenohypophysis (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 170-174
  • Duvilanski, B.H., Zambruno, C., Lasaga, M., Pisera, D., Seilicovich, A., Role of nitric oxide/cyclic GMP pathway in the inhibitory effect of GABA and dopamine on prolactin release (1996) J. Neuroendocrinol., 8, pp. 909-913
  • Grynkiewicz, G., Poenie, M., Tsien, R.Y., A new generation of Ca2+ indicators with greatly improved fluorescence properties (1985) J. Biol. Chem., 260, pp. 3440-3450
  • Knowles, R.G., Moncada, S., Nitric oxide synthases in mammals (1994) Biochem. J., 298, pp. 249-258
  • Kuryshev, Y.A., Childs, G.V., Ritchie, A.V., Corticotropin-releasing hormone stimulates Ca2+ entry through L- and P-type Ca2+ channels in rat corticotropes (1996) Endocrinology, 137, pp. 2269-2277
  • Lloyd, R.V., Jin, L., Qian, X., Zhang, S.Y., Scheithauer, B.W., Nitric oxide synthase in the human pituitary gland (1995) Am. J. Pathol., 146, pp. 86-94
  • Minowa, T., Miwa, S., Kobayashi, S., Enoki, T., Zhang, X.F., Komuro, T., Iwamuro, Y., Masaki, T., Inhibitory effect of nitrovasodilators and cyclic GMP on ET-1-activated Ca(2+)-permeable nonselective cation channel in rat aortic smooth muscle cells (1997) Br. J. Pharmacol., 120, pp. 1536-1544
  • Mollard, P., Werner, S., Why are the endocrine pituitary cells excittable? (1996) T.E.M., 7, pp. 361-365
  • Poderoso, J.J., Carreras, M.C., Lisdere, C., Riobo, N., Schopfer, F., Boveris, A., Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles (1996) Ann. Rev. Cell. Biol., 6, pp. 715-716
  • Roussel, J.P., Grazzini, E., Zumbihl, R., Rodriguez, E., Astier, H., Triiodo-L-thyronine enhances TRH-induced TSH release from perifused rat pituitaries and intracellular Ca2+ levels from dispersed pituitary cells (1995) Eur. J. Pharmacol., 289, pp. 205-215
  • Sakai, A., Kondo, M., Tamaoki, J., Konno, K., Nitric oxide modulation of Ca2+ responses in cow tracheal epithelium (1995) Eur. J. Pharmacol., 291, pp. 375-379
  • Satta, M.A., Jacobs, R.A., Kaltsas, G.A., Grossman, A.B., Endotoxin induces interleukin-1beta and nitric oxide synthase mRNA in rat hypothalamus and pituitary (1998) Neuroendocrinology, 67, pp. 109-116
  • Schobersberger, W., Friedrich, F., Hoffmann, G., Volkl, H., Dietl, P., Nitric oxide donors inhibit spontaneous depolarizations by L-type Ca2+ currents in alveolar epithelial cells (1997) Am. J. Physiol., 272, pp. 1092-L-1097
  • Seilicovich, A., Duvilanski, B.H., Pisera, D., Theas, S., Gimeno, M., Rettori, V., Mc Cann, S.M., Nitric oxide inhibits hypothalamic luteinizing hormone-releasing hormone release by releasing gamma-aminobutyric acid (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 3421-3424
  • Shono, M., Houchi, H., Oka, M., Nakaya, Y., Effects of nitroprusside and nicorandil on catecholamine secretion and calcium mobilization in cultured bovine adrenal chromaffin cells (1997) J. Cardiovasc. Pharmacol., 30, pp. 419-423
  • Stamler, J.S., Loscalzo, J., Capillary zone electrophoretic detection of biologial thiols and their S-nitrosated derivatives (1992) Anal. Chem., 64, pp. 779-786
  • Sundaresan, S., Weiss, J., Bauer-Dantoin, A.C., Jameson, J.L., Expression of ryanodine receptors in the pituitary gland: Evidence for a role in gonadotropin-releasing hormone signaling (1997) Endocrinology, 138, pp. 2056-2065
  • Thastrup, O., Cullen, P.J., Drobak, B.K., Hanley, M.R., Dawson, A.P., Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2+-ATPase (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 2466-2470
  • Tsien, R.W., Tsien, R.Y., Calcium channels, stores and oscillations (1990) Ann. Rev. Cell. Biol., 6, pp. 715-760
  • Tsuji, Y., Unno, N., Menconi, M.J., Smith, M., Fink, M.P., Nitric oxide donors increase cytosolic ionized calcium in cultured human epithelial cells (1996) Shock, 61, pp. 19-24
  • Vankelecom, H., Matthys, P., Denef, C., Inducible nitric oxide synthase in the anterior pituitary gland: Induction by interferon-gamma in a subpopulation of folliculo stellate cells and in an unidentifiable population of non-hormone-secreting cells (1997) J. Histochem. Cytochem., 45, pp. 847-857
  • Volk, T., Mading, K., Hensel, M., Kox, W.J., Nitric oxide induces transient Ca2+ changes in endothelial cells independent of cGMP (1997) J. Cell Physiol., 172, pp. 296-305
  • Wagner, K.A., Yacono, P.W., Golan, D.E., Tashjian, A.H.J., (1993) Biochem. J., 292, pp. 175-182
  • Yamada, K., Xu, Z.Q., Zhang, X., Gustafsson, L., Hulting, A.L., De Vente, J., Steinbusch, H.W., Hokfelt, T., Nitric oxide synthase and cGMP in the anterior pituitary gland: Effect of a GnRH antagonist and nitric oxide donors (1997) Neuroendocrinology, 65, pp. 147-156
  • Yu, W.H., Walczewska, A., Karanth, S., Mc Cann, S.M., Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland (1997) Endocrinology, 138, pp. 5055-5058
  • Yuan, X.J., Tod, M.L., Rubin, L.J., Blaustein, M.P., NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels (1996) Proc. Natl. Acad. Sci. USA, 93, pp. 10489-10494

Citas:

---------- APA ----------
Duvilanski, B.H., Velardez, M.O., Gonzalez Iglesias, A., Theas, S., Seilicovich, A. & Becu-Villalobos, D. (1998) . Nitric oxide donors modify free intracellular calcium levels in rat anterior pituitary cells. Molecular and Cellular Endocrinology, 146(1-2), 19-26.
http://dx.doi.org/10.1016/S0303-7207(98)00203-2
---------- CHICAGO ----------
Duvilanski, B.H., Velardez, M.O., Gonzalez Iglesias, A., Theas, S., Seilicovich, A., Becu-Villalobos, D. "Nitric oxide donors modify free intracellular calcium levels in rat anterior pituitary cells" . Molecular and Cellular Endocrinology 146, no. 1-2 (1998) : 19-26.
http://dx.doi.org/10.1016/S0303-7207(98)00203-2
---------- MLA ----------
Duvilanski, B.H., Velardez, M.O., Gonzalez Iglesias, A., Theas, S., Seilicovich, A., Becu-Villalobos, D. "Nitric oxide donors modify free intracellular calcium levels in rat anterior pituitary cells" . Molecular and Cellular Endocrinology, vol. 146, no. 1-2, 1998, pp. 19-26.
http://dx.doi.org/10.1016/S0303-7207(98)00203-2
---------- VANCOUVER ----------
Duvilanski, B.H., Velardez, M.O., Gonzalez Iglesias, A., Theas, S., Seilicovich, A., Becu-Villalobos, D. Nitric oxide donors modify free intracellular calcium levels in rat anterior pituitary cells. Mol. Cell. Endocrinol. 1998;146(1-2):19-26.
http://dx.doi.org/10.1016/S0303-7207(98)00203-2