Páez Pereda, M.; Goldberg, V.; Chervín, A.; Carrizo, G.; Molina, A.; Andrada, J.; Sauer, J.; Renner, U.; Stalla, G.K.; Arzt, E. "Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants" (1996) Molecular and Cellular Endocrinology. 124(1-2):33-42
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We have previously shown that interleukin-2 (IL-2) and IL-6, which are expressed in the anterior pituitary, affect anterior pituitary cell proliferation in normal rats and cell lines. Here we examined their effects on the c-fos expression by human anterior pituitary adenomas. Adenoma cells in culture do not express c-fos mRNA. In adenoma explants, however, c-fos expression was detected and was regulated by IL-2 or IL-6. In different tumors (ACTH-, PRL-, GH-secreting and non functioning adenomas), these interleukins had inhibitory or stimulatory effects but the kind of response does not seem to be associated to tumor type or size. Using blocking antibodies, we observed that intrinsic IL-2 and IL-6 regulate c-fos expression in the same way. Our data suggest that IL-2 and IL-6 are not only involved in the regulation of pituitary adenoma function but may also, given the role of c-fos in cell proliferation, be implicated in the development of human pituitary adenomas.


Documento: Artículo
Título:Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants
Autor:Páez Pereda, M.; Goldberg, V.; Chervín, A.; Carrizo, G.; Molina, A.; Andrada, J.; Sauer, J.; Renner, U.; Stalla, G.K.; Arzt, E.
Filiación:Inst. de Invest. Médicas, Facultad de Medicina, Universidad de Buenos Aires, Donato Alvarez 3150, 1427 Buenos Aires, Argentina
Departamento de Biología, FCEN, Universidad de Buenos Aires, Donato Alvarez 3150, 1427 Buenos Aires, Argentina
Hospital Santa Lucia, Buenos Aires, Argentina
Hospital Ramos Mejía, Buenos Aires, Argentina
Max-Planck Institute of Psychiatry, Clinical Institute, Kraepelinstr. 10, 80804 Munich, Germany
Palabras clave:c-fos; Interleukin-2; Interleukin-6; Pituitary adenomas; blocking antibody; corticotropin; growth hormone; interleukin 2; interleukin 2 receptor antibody; interleukin 6; interleukin 6 antibody; messenger rna; prolactin; adenohypophysis; adult; article; cell proliferation; controlled study; corticotropin release; explant; female; gene expression regulation; growth hormone release; human; human cell; hypophysis adenoma; immunohistochemistry; male; northern blotting; oncogene c fos; priority journal; prolactin release; proto oncogene; Adenoma; Adolescent; Adult; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Interleukin-2; Interleukin-6; Male; Middle Aged; Pituitary Gland, Anterior; Pituitary Neoplasms; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured
Página de inicio:33
Página de fin:42
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:MOL. CELL. ENDOCRINOL.
CAS:Interleukin-2; Interleukin-6; RNA, Messenger; RNA, Neoplasm


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---------- APA ----------
Páez Pereda, M., Goldberg, V., Chervín, A., Carrizo, G., Molina, A., Andrada, J., Sauer, J.,..., Arzt, E. (1996) . Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants. Molecular and Cellular Endocrinology, 124(1-2), 33-42.
---------- CHICAGO ----------
Páez Pereda, M., Goldberg, V., Chervín, A., Carrizo, G., Molina, A., Andrada, J., et al. "Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants" . Molecular and Cellular Endocrinology 124, no. 1-2 (1996) : 33-42.
---------- MLA ----------
Páez Pereda, M., Goldberg, V., Chervín, A., Carrizo, G., Molina, A., Andrada, J., et al. "Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants" . Molecular and Cellular Endocrinology, vol. 124, no. 1-2, 1996, pp. 33-42.
---------- VANCOUVER ----------
Páez Pereda, M., Goldberg, V., Chervín, A., Carrizo, G., Molina, A., Andrada, J., et al. Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants. MOL. CELL. ENDOCRINOL. 1996;124(1-2):33-42.