Artículo

Barttfeld, P.; Petroni, A.; Báez, S.; Urquina, H.; Sigman, M.; Cetkovich, M.; Torralva, T.; Torrente, F.; Lischinsky, A.; Castellanos, X.; Manes, F.; Ibañez, A. "Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder" (2014) Neuropsychobiology. 69(2):65-75
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Abstract:

Objectives: To assess brain functional connectivity and variability in adults with attention deficit/hyperactivity disorder (ADHD) or euthymic bipolar disorder (BD) relative to a control (CT) group. Methods: Electroencephalography (EEG) was measured in 35 participants (BD = 11; ADHD = 9; CT = 15) during an eyes-closed 10-min rest period, and connectivity and graph theory metrics were computed. A coefficient of variation (CV) computed also the connectivity's temporal variability of EEG. Multivariate associations between functional connectivity and clinical and neuropsychological profiles were evaluated. Results: An enhancement of functional connectivity was observed in the ADHD (fronto-occipital connections) and BD (diffuse connections) groups. However, compared with CTs, intrinsic variability (CV) was enhanced in the ADHD group and reduced in the BD group. Graph theory metrics confirmed the existence of several abnormal network features in both affected groups. Significant associations of connectivity with symptoms were also observed. In the ADHD group, temporal variability of functional connections was associated with executive function and memory deficits. Depression, hyperactivity and impulsivity levels in the ADHD group were associated with abnormal intrinsic connectivity. In the BD group, levels of anxiety and depression were related to abnormal frontotemporal connectivity. Conclusions: In the ADHD group, we found that intrinsic variability was associated with deficits in cognitive performance and that connectivity abnormalities were related to ADHD symptomatology. The BD group exhibited less intrinsic variability and more diffuse long-range brain connections, and those abnormalities were related to interindividual differences in depression and anxiety. These preliminary results are relevant for neurocognitive models of abnormal brain connectivity in both disorders. © 2014 S. Karger AG, Basel.

Registro:

Documento: Artículo
Título:Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder
Autor:Barttfeld, P.; Petroni, A.; Báez, S.; Urquina, H.; Sigman, M.; Cetkovich, M.; Torralva, T.; Torrente, F.; Lischinsky, A.; Castellanos, X.; Manes, F.; Ibañez, A.
Filiación:Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology, Favaloro University, Argentina
Integrative Neuroscience Laboratory, Physics Department, University of Buenos Aires, Argentina
National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina
Laboratory of Cognitive and Social Neuroscience, UDP-INECO Foundation Core on Neuroscience, Diego Portales University, Santiago, Chile
Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, Child Study Center, NYU Langone School of Medicine, New York, NY, United States
Universidad Autónoma Del Caribe, Barranquilla, Colombia
Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology, CONICET Pacheco de Melo 1860, Buenos Aires, Argentina
Palabras clave:Attention deficit/hyperactivity disorder; Bipolar disorder; Electroencephalography; Functional connectivity; Intrinsic variability; adult; amnesia; anxiety; article; attention deficit disorder; bipolar disorder; brain function; brain functional connectivity; brain variability; clinical article; clinical assessment; clinical evaluation; controlled study; depression; disease association; educational status; electroencephalography; executive function; female; frontal lobe; human; hyperactivity; impulsiveness; male; neuropsychological test; priority journal; attention deficit disorder; bipolar disorder; brain; cognitive defect; middle aged; multivariate analysis; nerve tract; pathophysiology; physiology; psychology; rest; time; Article; comparative study; electroencephalogram; functional connectivity; functional magnetic resonance imaging; neurologic examination; temporal variability; Adult; Anxiety; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Brain; Cognition Disorders; Depression; Electroencephalography; Humans; Impulsive Behavior; Male; Middle Aged; Multivariate Analysis; Neural Pathways; Neuropsychological Tests; Rest; Time Factors
Año:2014
Volumen:69
Número:2
Página de inicio:65
Página de fin:75
DOI: http://dx.doi.org/10.1159/000356964
Título revista:Neuropsychobiology
Título revista abreviado:Neuropsychobiology
ISSN:0302282X
CODEN:NPBYA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0302282X_v69_n2_p65_Barttfeld

Referencias:

  • Chang, K.D., Course and impact of bipolar disorder in young patients (2010) J Clin Psychiatry, 71, pp. e05
  • Klassen, L.J., Katzman, M.A., Chokka, P., Adult ADHD and its comorbidities, with a focus on bipolar disorder (2010) J Affect Disord, 124, pp. 1-8
  • Wingo, A.P., Ghaemi, S.N., A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder (2007) Journal of Clinical Psychiatry, 68 (11), pp. 1776-1784
  • Ibanez, A., Cetkovich, M., Petroni, A., Urquina, H., Baez, S., Gonzalez-Gadea, M.L., Kamienkowski, J.E., Manes, F., The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD) (2012) PLoS One, 7, pp. e37306
  • Torralva, T., Gleichgerrcht, E., Torrente, F., Roca, M., Strejilevich, S.A., Cetkovich, M., Lischinsky, A., Manes, F., Neuropsychological functioning in adult bipolar disorder and ADHD patients: A comparative study (2011) Psychiatry Res, 186, pp. 261-266
  • Ibanez, A., Aguado, J., Baez, S., Huepe, D., Lopez, V., Ortega, R., Sigman, M., Manes, F., From neural signatures of emotional modulation to social cognition: Individual differences in healthy volunteers and psychiatric participants Soc Cogn Affect Neurosci, , Epub ahead of print
  • Raichle, M.E., Neuroscience. The brain's dark energy (2006) Science, 314, pp. 1249-1250
  • Raichle, M.E., Snyder, A.Z., A default mode of brain function: A brief history of an evolving idea (2007) NeuroImage, 37 (4), pp. 1083-1090. , DOI 10.1016/j.neuroimage.2007.02.041, PII S1053811907001309
  • Fox, M.D., Zhang, D., Snyder, A.Z., Raichle, M.E., The global signal and observed anticorrelated resting state brain networks (2009) J Neurophysiol, 101, pp. 3270-3283
  • Eryilmaz, H., Van De Ville, D., Schwartz, S., Vuilleumier, P., Impact of transient emotions on functional connectivity during subsequent resting state: A wavelet correlation approach (2011) Neuroimage, 54, pp. 2481-2491
  • Tau, G.Z., Peterson, B.S., Normal development of brain circuits (2010) Neuropsychopharmacology, 35, pp. 147-168
  • Bush, G., Attention-deficit/hyperactivity disorder and attention networks (2010) Neuropsychopharmacology, 35, pp. 278-300
  • Sonuga-Barke, E.J.S., Castellanos, F.X., Spontaneous attentional fluctuations in impaired states and pathological conditions: A neurobiological hypothesis (2007) Neuroscience and Biobehavioral Reviews, 31 (7), pp. 977-986. , DOI 10.1016/j.neubiorev.2007.02.005, PII S014976340700022X
  • Broyd, S.J., Demanuele, C., Debener, S., Helps, S.K., James, C.J., Sonuga-Barke, E.J., Default-mode brain dysfunction in mental disorders: A systematic review (2009) Neurosci Biobehav Rev, 33, pp. 279-296
  • Wessa, M., Houenou, J., Paillere-Martinot, M.-L., Berthoz, S., Artiges, E., Leboyer, M., Martinot, J.-L., Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task (2007) American Journal of Psychiatry, 164 (4), pp. 638-646. , DOI 10.1176/appi.ajp.164.4.638
  • Palaniyappan, L., Cousins, D.A., Brain networks: Foundations and futures in bipolar disorder (2010) J Ment Health, 19, pp. 157-167
  • Kapczinski, F., Dal-Pizzol, F., Teixeira, A.L., Magalhaes, P.V., Kauer-Santanna, M., Klamt, F., Moreira, J.C., Post, R., Peripheral biomarkers and illness activity in bipolar disorder (2011) J Psychiatr Res, 45, pp. 156-161
  • Kapczinski, F., Frey, B.N., Kauer-Sant'Anna, M., Grassi-Oliveira, R., Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder (2008) Expert Review of Neurotherapeutics, 8 (7), pp. 1101-1113. , http://www.expert-reviews.com/doi/pdf/10.1586/14737175.8.7.1101, DOI 10.1586/14737175.8.7.1101
  • El-Badri, S.M., Heather Ashton, C., Brian Moore, P., Richard Marsh, V., Nicol Ferrier, I., Electrophysiological and cognitive function in young euthymic patients with bipolar affective disorder (2001) Bipolar Disorders, 3 (2), pp. 79-87. , DOI 10.1034/j.1399-5618.2001.030206.x
  • Ozerdem, A., Guntekin, B., Saatci, E., Tunca, Z., Basar, E., Disturbance in long distance gamma coherence in bipolar disorder (2010) Prog Neuropsychopharmacol Biol Psychiatry, 34, pp. 861-865
  • Ozerdem, A., Kocaaslan, S., Tunca, Z., Basar, E., Event related oscillations in euthymic patients with bipolar disorder (2008) Neurosci Lett, 444, pp. 5-10
  • Blumberg, H.P., Stern, E., Ricketts, S., Martinez, D., De Asis, J., White, T., Epstein, J., Silbersweig, D.A., Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder (1999) Am J Psychiatry, 156, pp. 1986-1988
  • Ongur, D., Lundy, M., Greenhouse, I., Shinn, A.K., Menon, V., Cohen, B.M., Renshaw, P.F., Default mode network abnormalities in bipolar disorder and schizophrenia (2010) Psychiatry Res, 183, pp. 59-68
  • Chen, A.C., Feng, W., Zhao, H., Yin, Y., Wang, P., EEG default mode network in the human brain: Spectral regional field powers (2008) Neuroimage, 41, pp. 561-574
  • Hlinka, J., Alexakis, C., Diukova, A., Liddle, P.F., Auer, D.P., Slow EEG pattern predicts reduced intrinsic functional connectivity in the default mode network: An inter-subject analysis (2010) Neuroimage, 53, pp. 239-246
  • He, B.J., Raichle, M.E., The fMRI signal, slow cortical potential and consciousness (2009) Trends Cogn Sci, 13, pp. 302-309
  • He, B.J., Zempel, J.M., Snyder, A.Z., Raichle, M.E., The temporal structures and functional significance of scale-free brain activity (2010) Neuron, 66, pp. 353-369
  • Ibanez, A., Petroni, A., Urquina, H., Torrente, F., Torralva, T., Hurtado, E., Guex, R., Manes, F., Cortical deficits of emotional face processing in adults with ADHD: Its relation to social cognition and executive function (2011) Soc Neurosci, 6, pp. 464-481
  • Torralva, T., Strejilevich, S., Gleichgerrcht, E., Roca, M., Martino, D., Cetkovich, M., Manes, F., Deficits in tasks of executive functioning that mimic real-life scenarios in bipolar disorder (2012) Bipolar Disord, 14, pp. 118-125
  • Ibanez, A., Manes, F., Contextual social cognition and the behavioral variant of frontotemporal dementia (2012) Neurology, 78, pp. 1354-1362
  • Baez, S., Herrera, E., Villarin, L., Theil, D., Gonzalez-Gadea, M.L., Gomez, P., Mosquera, M., Ibanez, A.M., Contextual social cognition impairments in schizophrenia and bipolar disorder (2013) PLoS One, 8, pp. e57664
  • Ibanez, A., Urquina, H., Petroni, A., Baez, S., Lopez, V., Do Nascimento, M., Herrera, E., Manes, F., Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM) (2012) PLoS One, 7, pp. e46877
  • Delorme, A., Makeig, S., EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis (2004) Journal of Neuroscience Methods, 134 (1), pp. 9-21. , DOI 10.1016/j.jneumeth.2003.10.009
  • Montez, T., Linkenkaer-Hansen, K., Van Dijk, B.W., Stam, C.J., Synchronization likelihood with explicit time-frequency priors (2006) NeuroImage, 33 (4), pp. 1117-1125. , DOI 10.1016/j.neuroimage.2006.06.066, PII S1053811906007154
  • Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Sigman, M., A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections (2011) Neuropsychologia, 49, pp. 254-263
  • Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Leiguarda, R., Sigman, M., State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder (2012) Neuropsychologia, 50, pp. 3653-3662
  • Gallos, L.K., Barttfeld, P., Havlin, S., Sigman, M., Makse, H.A., Collective behavior in the spatial spreading of obesity (2012) Sci Rep, 2, p. 454
  • Gallos, L.K., Makse, H.A., Sigman, M., A small world of weak ties provides optimal global integration of self-similar modules in functional brain networks (2012) Proc Natl Acad Sci USA, 109, pp. 2825-2830
  • Gallos, L.K., Sigman, M., Makse, H.A., The conundrum of functional brain networks: Smallworld efficiency or fractal modularity (2012) Front Physiol, 3, p. 123
  • Barttfeld, P., Amoruso, L., Ais, J., Cukier, S., Bavassi, L., Tomio, A., Manes, F., Sigman, M., Organization of brain networks governed by long-range connections index autistic traits in the general population (2013) J Neurodev Disord, 5, p. 16
  • Rubinov, M., Sporns, O., Complex network measures of brain connectivity: Uses and interpretations (2010) Neuroimage, 52, pp. 1059-1069
  • Couto, B., Manes, F., Montanes, P., Matallana, D., Reyes, P., Velasquez, M., Yoris, A., Ibanez, A., Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia (2013) Front Hum Neurosci, 7, p. 467
  • Stam, C.J., Reijneveld, J.C., Graph theoretical analysis of complex networks in the brain (2007) Nonlinear Biomed Phys, 1, p. 3
  • Murias, M., Swanson, J.M., Srinivasan, R., Functional connectivity of frontal cortex in healthy and adhd children reflected in EEG coherence (2007) Cerebral Cortex, 17 (8), pp. 1788-1799. , DOI 10.1093/cercor/bhl089
  • Zylberberg, A., Ouellette, B., Sigman, M., Roelfsema, P.R., Decision making during the psychological refractory period (2012) Curr Biol, 22, pp. 1795-1799
  • Sigman, M., Dehaene, S., Brain mechanisms of serial and parallel processing during dualtask performance (2008) J Neurosci, 28, pp. 7585-7598
  • Dehaene, S., Sigman, M., From a single decision to a multi-step algorithm (2012) Curr Opin Neurobiol, 22, pp. 937-945
  • Balsters, J.H., Oconnell, R.G., Martin, M.P., Galli, A., Cassidy, S.M., Kilcullen, S.M., Delmonte, S., Robertson, I.H., Donepezil impairs memory in healthy older subjects: Behavioural, EEG and simultaneous EEG/fMRI biomarkers (2011) PLoS One, 6, pp. e24126
  • Malloy-Diniz, L.F., Fuentes, D., Leite, W.B., Correa, H., Bechara, A., Impulsive behavior in adults with attention deficit/hyperactivity disorder: Characterization of attentional, motor and cognitive impulsiveness (2007) Journal of the International Neuropsychological Society, 13 (4), pp. 693-698. , DOI 10.1017/S1355617707070889
  • Gonzalez-Gadea, M.L., Baez, S., Torralva, T., Castellanos, F.X., Rattazzi, A., Bein, V., Rogg, K., Ibanez, A., Cognitive variability in adults with ADHD and AS: Disentangling the roles of executive functions and social cognition (2013) Res Dev Disabil, 34, pp. 817-830
  • Castellanos, F.X., Sonuga-Barke, E.J., Milham, M.P., Tannock, R., Characterizing cognition in ADHD: Beyond executive dysfunction (2006) Trends Cogn Sci, 10, pp. 117-123
  • Castellanos, F.X., Kelly, C., Milham, M.P., The restless brain: Attention-deficit hyperactivity disorder, resting-state functional connectivity, and intrasubject variability (2009) Can J Psychiatry, 54, pp. 665-672
  • Greicius, M.D., Flores, B.H., Menon, V., Glover, G.H., Solvason, H.B., Kenna, H., Reiss, A.L., Schatzberg, A.F., Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus (2007) Biological Psychiatry, 62 (5), pp. 429-437. , DOI 10.1016/j.biopsych.2006.09.020, PII S0006322306011930
  • Taylor, C.T., Hirshfeld-Becker, D.R., Ostacher, M.J., Chow, C.W., LeBeau, R.T., Pollack, M.H., Nierenberg, A.A., Simon, N.M., Anxiety is associated with impulsivity in bipolar disorder (2008) Journal of Anxiety Disorders, 22 (5), pp. 868-876. , DOI 10.1016/j.janxdis.2007.09.001, PII S0887618507001715
  • Liao, W., Chen, H., Feng, Y., Mantini, D., Gentili, C., Pan, Z., Ding, J., Zhang, W., Selective aberrant functional connectivity of resting state networks in social anxiety disorder (2010) Neuroimage, 52, pp. 1549-1558
  • Grande, I., Fries, G.R., Kunz, M., Kapczinski, F., The role of BDNF as a mediator of neuroplasticity in bipolar disorder (2010) Psychiatry Investig, 7, pp. 243-250

Citas:

---------- APA ----------
Barttfeld, P., Petroni, A., Báez, S., Urquina, H., Sigman, M., Cetkovich, M., Torralva, T.,..., Ibañez, A. (2014) . Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder. Neuropsychobiology, 69(2), 65-75.
http://dx.doi.org/10.1159/000356964
---------- CHICAGO ----------
Barttfeld, P., Petroni, A., Báez, S., Urquina, H., Sigman, M., Cetkovich, M., et al. "Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder" . Neuropsychobiology 69, no. 2 (2014) : 65-75.
http://dx.doi.org/10.1159/000356964
---------- MLA ----------
Barttfeld, P., Petroni, A., Báez, S., Urquina, H., Sigman, M., Cetkovich, M., et al. "Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder" . Neuropsychobiology, vol. 69, no. 2, 2014, pp. 65-75.
http://dx.doi.org/10.1159/000356964
---------- VANCOUVER ----------
Barttfeld, P., Petroni, A., Báez, S., Urquina, H., Sigman, M., Cetkovich, M., et al. Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder. Neuropsychobiology. 2014;69(2):65-75.
http://dx.doi.org/10.1159/000356964