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Abstract:

The toll-like receptor 4 (TLR4) plays a key role in the activation of innate immune response participating in the recognition of lipopolysaccharides. Changes in the innate immune response are involved in the pathogenesis of some metabolic disorders such as metabolic syndrome and type 2 diabetes mellitus (Met-S and T2DM). It has been recently shown the role of gut microbiota in the perpetuation of both insulin resistance and low-grade chronic inflammation. Some studies have reported that TLR4 D299G polymorphism is associated with metabolic disorders, however results have been inconsistent. Two recent meta-analyses showed that D299G is associated with inflammatory bowel disease and gastrointestinal cancers risk, two pathological states in which the luminal microbial flora-host cells interaction may be implicated. We conducted a systemic review of the published data considering all eligible published studies (six studies with 1696 cases and 3388 controls for D299G) and a meta-analysis was performed to evaluate the association between TLR4 D299G polymorphism and the risk for metabolic disorders. Five studies were identified for T2DM: three corresponding to Caucasian populations and two to mixed populations. The remaining study analyzed Met-S in a Caucasian population. We observed a significant association between D299G polymorphism and metabolic disorders (T2DM and Met-S) risk (OR = 0.566, 95 % CI: 0.347-0.925, p = 0.023) particularly in Caucasians. No association was found in mixed population subgroup. Our meta-analysis identified that the AG/GG genotypes of D299G are associated with decreased metabolic disorders risk. © 2012 Springer Science+Business Media Dordrecht.

Registro:

Documento: Artículo
Título:Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis
Autor:S. Belforte, F.; Coluccio Leskow, F.; Poskus, E.; Penas Steinhardt, A.
Filiación:Laboratorio de Biología Molecular, INIGEM CONICET-UBA and Cátedra de Genética y Bilogía Molecular, Universidad de Buenos Aires, Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Lujan, Ruta 7 y Av. Constitución, Luján Buenos Aires, Argentina
Instituto de Estudios de la Inmunidad Humoral (IDEHU), CONICET-UBA and Cátedra de Inmunología, Universidad de Buenos Aires, Buenos Aires, Argentina
División Endocrinología, Hospital de Clínicas, Universidad de Buenos Aires (UBA), Junín 956, 4 piso (1113), Buenos Aires, Argentina
Palabras clave:D299G; Diabetes; Meta-analysis; Metabolic syndrome; Polymorphism; TLR4; toll like receptor 4; article; Caucasian; cell interaction; Crohn disease; digestive system cancer; disease association; enteritis; ethnicity; gene frequency; geographic distribution; human; metabolic disorder; non insulin dependent diabetes mellitus; protein polymorphism; systematic review; ulcerative colitis; Diabetes Mellitus, Type 2; European Continental Ancestry Group; Genetic Predisposition to Disease; Humans; Immunity, Innate; Inflammatory Bowel Diseases; Insulin Resistance; Lipopolysaccharides; Metabolic Syndrome X; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Toll-Like Receptor 4
Año:2013
Volumen:40
Número:4
Página de inicio:3015
Página de fin:3020
DOI: http://dx.doi.org/10.1007/s11033-012-2374-5
Título revista:Molecular Biology Reports
Título revista abreviado:Mol. Biol. Rep.
ISSN:03014851
CODEN:MLBRB
CAS:toll like receptor 4, 203811-83-0; Lipopolysaccharides; Toll-Like Receptor 4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03014851_v40_n4_p3015_SBelforte

Referencias:

  • Rock, F.L., Hardiman, G., Timans, J.C., Kastelein, R.A., Bazan, J.F., A family of human receptors structurally related to Drosophila Toll (1998) Proc Natl Acad Sci USA, 95 (2), pp. 588-593. , 9435236 10.1073/pnas.95.2.588 1:CAS:528:DyaK1cXmtFWqtQ%3D%3D
  • Barton, G.M., Medzhitov, R., Toll-like receptor signaling pathways (2003) Science, 300 (5625), pp. 1524-1525. , 12791976 10.1126/science.1085536 1:CAS:528:DC%2BD3sXktlKru7w%3D
  • Pickup, J.C., Mattock, M.B., Chusney, G.D., Burt, D., NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X (1997) Diabetologia, 40 (11), pp. 1286-1292. , http://www.ncbi.nlm.nih.gov/pubmed/9389420, Accessed October 21, 2012
  • Pickup, J.C., Crook, M.A., Is type II diabetes mellitus a disease of the innate immune system? (1998) Diabetologia, 41 (10), pp. 1241-1248. , 9794114 10.1007/s001250051058 1:CAS:528:DyaK1cXmtlais70%3D
  • Takeda, K., Kaisho, T., Akira, S., Toll-like receptors (2003) Ann Rev Immunol., 21, pp. 335-376. , http://www.ncbi.nlm.nih.gov/pubmed/12524386, Accessed October 13, 2010
  • Hotamisligil, G.S., Inflammation and metabolic disorders (2006) Nature, 444 (7121), pp. 860-867. , http://www.ncbi.nlm.nih.gov/pubmed/17167474, Accessed October 4, 2012
  • Petruzzelli, M., Moschetta, A., Intestinal ecology in the metabolic syndrome (2010) Cell Metab., 11 (5), pp. 345-346. , http://dx.doi.org/10.1016/j.cmet.2010.04.012
  • Tsukumo, D., Carvalho-Filho, M., Carvalheira, J., Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance (2007) Diabetes, 56, pp. 1986-1998. , 17519423 10.2337/db06-1595 1:CAS:528:DC%2BD2sXos12qsrY%3D
  • Maldonado-Bernal, C.T., Low frequency of toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with type 2 diabetes (2011) Int J Immunogenet., 38 (6), pp. 519-523. , http://www.ncbi.nlm.nih.gov/pubmed/21902816, Accessed October 10, 2012
  • Arbour, N.C., Lorenz, E., Schutte, B.C., TLR4 mutations are associated with endotoxin hyporesponsiveness in humans (2000) Nat Genet., 25 (2), pp. 187-191. , http://www.ncbi.nlm.nih.gov/pubmed/10835634
  • Steinhardt, A.P., Aranguren, F., Tellechea, M.L., A functional nonsynonymous toll-like receptor 4 gene polymorphism is associated with metabolic syndrome, surrogates of insulin resistance, and syndromes of lipid accumulation (2009) Metabolism, , http://www.ncbi.nlm.nih.gov/pubmed/19922963
  • Ferwerda, B., Mbb, M., Verheijen, K., Functional consequences of toll-like receptor 4 polymorphisms (2008) Mol Med., 14 (5-6), p. 346. , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215765/, Accessed March 5, 2012
  • Figueroa, L., Xiong, Y., Song, C., The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF (2012) J Immunol., 188 (9), pp. 4506-4515. , http://www.ncbi.nlm.nih.gov/pubmed/22474023, Accessed November 12, 2012
  • Shen, X., Shi, R., Zhang, H., The toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcerative colitis: A meta-analysis (2010) Receptor, pp. 69-77
  • Jing, J.J., Li, M., Yuan, Y., Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in cancer: A meta-analysis (2012) Gene, 499 (2), pp. 237-242. , http://www.ncbi.nlm.nih.gov/pubmed/22441122, Accessed November 12, 2012
  • Higgins, J.P.T., Thompson, S.G., Deeks, J.J., Altman, D.G., Measuring inconsistency in meta-analyses (2003) BMJ, 327 (7414), pp. 557-560. , http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 192859&tool=pmcentrez&rendertype=abstract, Accessed October 6, 2012
  • Petitti, D.B., (2000) Meta-analysis, Decision Analysis, and Cost-effectiveness Analysis: Methods for Quantitative Synthesis in Medicine, , 2 Oxford University Press New York
  • Thomas, I., Friedhelm, B., Andreas, S., Rolf, H., Sylvia, M., Wolfgang, R., Wolfgang, K., Hubert, K., The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome (2003) World Health, 52, pp. 1-4. , for The KORA Study Group1 2
  • Kolek, M.J., Carlquist, J.F., Muhlestein, J.B., Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes (2004) Am Heart J., 148 (6), pp. 1034-1040. , http://www.ncbi.nlm.nih.gov/pubmed/15632890, Accessed June 22, 2011
  • Bagarolli, R.A., Saad, M.J., Saad, S.T.O., Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with type 2 diabetes (2009) J Diabetes Complicat, p. 4
  • Manolakis, A.C., Kapsoritakis, A.N., Tiaka, E.K., TLR4 gene polymorphisms: Evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease (2011) Eur J Endocrinol/Eur Fed Endocri Soc., 165 (2), pp. 261-267. , http://www.ncbi.nlm.nih.gov/pubmed/21628510, Accessed October 10, 2012
  • Amyot, J., Semache, M., Ferdaoussi, M., Fontés, G., Poitout, V., Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via toll-like receptor-4 and NF-κB signaling (2012) PLoS One., 7 (4), pp. e36200. , http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 3338606&tool=pmcentrez&rendertype=abstract, Accessed October 22, 2012
  • Ferwerda, B., McCall, M.B.B., Alonso, S., TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans (2007) PNAS USA, 104 (42), pp. 16645-16650. , 17925445 10.1073/pnas.0704828104
  • Johnson, G.B., Riggs, B.L., Platt, J.L., Biology, T., Clinic, M., A genetic basis for the "adonis" phenotype of low adiposity and strong bones (2004) FASEB J, 4, pp. 1-15. , 1:STN:280:DC%2BD2c7ntlemsg%3D%3D
  • Penas-Steinhardt, A., Barcos, L.S., Belforte, F.S., De Sereday, M., Vilariño, J., Functional characterization of TLR4 +3725 G/C polymorphism and association with protection against overweight (2012) PLoS ONE, 7 (12), p. 50992. , 10.1371/journal.pone.0050992 23239997 10.1371/journal.pone.0050992 1:CAS:528:DC%2BC38XhvFSksLzO
  • Sato, K., Yoshimura, A., Kaneko, T., A single nucleotide polymorphism in 3′-untranslated region contributes to the regulation of toll-like receptor 4 translation (2012) J Biol Chem., 287 (30), pp. 25163-25172. , http://www.ncbi.nlm.nih.gov/pubmed/22661708, Accessed November 21, 2012

Citas:

---------- APA ----------
S. Belforte, F., Coluccio Leskow, F., Poskus, E. & Penas Steinhardt, A. (2013) . Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis. Molecular Biology Reports, 40(4), 3015-3020.
http://dx.doi.org/10.1007/s11033-012-2374-5
---------- CHICAGO ----------
S. Belforte, F., Coluccio Leskow, F., Poskus, E., Penas Steinhardt, A. "Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis" . Molecular Biology Reports 40, no. 4 (2013) : 3015-3020.
http://dx.doi.org/10.1007/s11033-012-2374-5
---------- MLA ----------
S. Belforte, F., Coluccio Leskow, F., Poskus, E., Penas Steinhardt, A. "Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis" . Molecular Biology Reports, vol. 40, no. 4, 2013, pp. 3015-3020.
http://dx.doi.org/10.1007/s11033-012-2374-5
---------- VANCOUVER ----------
S. Belforte, F., Coluccio Leskow, F., Poskus, E., Penas Steinhardt, A. Toll-like receptor 4 D299G polymorphism in metabolic disorders: A meta-analysis. Mol. Biol. Rep. 2013;40(4):3015-3020.
http://dx.doi.org/10.1007/s11033-012-2374-5